| Small‐Molecule Stabilization of Protein–Protein Interactions: An Underestimated Concept in Drug Discovery? P Thiel, M Kaiser, C Ottmann Angewandte Chemie International Edition 51 (9), 2012-2018, 2012 | 243 | 2012 |
| Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling M Molzan, B Schumacher, C Ottmann, A Baljuls, L Polzien, M Weyand, ... Molecular and cellular biology 30 (19), 4698-4711, 2010 | 152 | 2010 |
| A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface C Anders, Y Higuchi, K Koschinsky, M Bartel, B Schumacher, P Thiel, ... Chemistry & Biology 20 (4), 583-593, 2013 | 108 | 2013 |
| Structure of the p53 C-terminus bound to 14-3-3: implications for stabilization of the p53 tetramer B Schumacher, J Mondry, P Thiel, M Weyand, C Ottmann FEBS letters 584 (8), 1443-1448, 2010 | 104 | 2010 |
| Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactions E Sijbesma, E Visser, K Plitzko, P Thiel, LG Milroy, M Kaiser, L Brunsveld, ... Nature Communications 11 (1), 1-9, 2020 | 55 | 2020 |
| Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein–protein interactions P Thiel, L Röglin, N Meissner, S Hennig, O Kohlbacher, C Ottmann Chemical Communications 49 (76), 8468-8470, 2013 | 51 | 2013 |
| Stabilization of protein–protein interactions in chemical biology and drug discovery D Bier, P Thiel, J Briels, C Ottmann Progress in biophysics and molecular biology 119 (1), 10-19, 2015 | 49 | 2015 |
| EpiToolKit—a web server for computational immunomics M Feldhahn, P Thiel, MM Schuler, N Hillen, S Stevanović, ... Nucleic acids research 36 (suppl_2), W519-W522, 2008 | 36 | 2008 |
| DNA-binding proteins from marine bacteria expand the known sequence diversity of TALE-like repeats O de Lange, C Wolf, P Thiel, J Krüger, C Kleusch, O Kohlbacher, ... Nucleic acids research 43 (20), 10065-10080, 2015 | 31 | 2015 |
| FRED—a framework for T-cell epitope detection M Feldhahn, P Dönnes, P Thiel, O Kohlbacher Bioinformatics 25 (20), 2758-2759, 2009 | 29 | 2009 |
| Covalent attachment of pyridoxal-phosphate derivatives to 14-3-3 proteins L Röglin, P Thiel, O Kohlbacher, C Ottmann Proceedings of the National Academy of Sciences 109 (18), E1051-E1053, 2012 | 20 | 2012 |
| Niedermolekulare Stabilisatoren von Protein‐Protein‐Wechselwirkungen: ein unterschätztes Konzept in der Wirkstoffentwicklung? P Thiel, M Kaiser, C Ottmann Angewandte Chemie 124 (9), 2052-2059, 2012 | 19 | 2012 |
| Blocked inverted indices for exact clustering of large chemical spaces P Thiel, L Sach-Peltason, C Ottmann, O Kohlbacher Journal of chemical information and modeling 54 (9), 2395-2401, 2014 | 12 | 2014 |
| Portals and web-based resources for virtual screening J Krueger, P Thiel, I Merelli, R Grunzke, S Gesing Current drug targets 17 (14), 1649-1660, 2016 | 10 | 2016 |
| Ballaxy: web services for structural bioinformatics AK Hildebrandt, D Stöckel, NM Fischer, L de la Garza, J Krüger, S Nickels, ... Bioinformatics 31 (1), 121-122, 2015 | 10 | 2015 |
| Bivalent phosphonate inhibitors for extracellular 14-3-3 protein targets: PB-074 J Briels, M Bartel, E Yilmaz, P Thiel, M Kaiser, C Ottmann Protein Science 24, 2015 | | 2015 |
| Deterministic clustering of the available chemical space P Thiel, L Peltason, C Ottmann, O Kohlbacher Journal of Cheminformatics 5 (S1), P53, 2013 | | 2013 |
| Binary complex of 14-3-3 sigma/p53 pT387-peptide and implications for stabilization. B Schumacher, J Mondry, P Thiel, M Weyand, C Ottmann ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES 66, S148-S149, 2010 | | 2010 |
Christian OttmannEindhoven University of Technologyכתובת אימייל מאומתת בדומיין tue.nl