TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection F Alfei, K Kanev, M Hofmann, M Wu, HE Ghoneim, P Roelli, ... Nature 571 (7764), 265-269, 2019 | 812 | 2019 |
De novo epigenetic programs inhibit PD-1 blockade-mediated T cell rejuvenation HE Ghoneim, Y Fan, A Moustaki, HA Abdelsamed, P Dash, P Dogra, ... Cell 170 (1), 142-157. e19, 2017 | 726 | 2017 |
Effector CD8 T cells dedifferentiate into long-lived memory cells B Youngblood, JS Hale, HT Kissick, E Ahn, X Xu, A Wieland, K Araki, ... Nature 552 (7685), 404-409, 2017 | 524 | 2017 |
Depletion of alveolar macrophages during influenza infection facilitates bacterial superinfections HE Ghoneim, PG Thomas, JA McCullers The Journal of Immunology 191 (3), 1250-1259, 2013 | 459 | 2013 |
Developmental plasticity allows outside-in immune responses by resident memory T cells R Fonseca, LK Beura, CF Quarnstrom, HE Ghoneim, Y Fan, CC Zebley, ... Nature immunology 21 (4), 412-421, 2020 | 275 | 2020 |
Human memory CD8 T cell effector potential is epigenetically preserved during in vivo homeostasis HA Abdelsamed, A Moustaki, Y Fan, P Dogra, HE Ghoneim, CC Zebley, ... Journal of Experimental Medicine 214 (6), 1593-1606, 2017 | 157 | 2017 |
Inflammasome-independent role of the apoptosis-associated speck-like protein containing CARD (ASC) in the adjuvant effect of MF59 AH Ellebedy, C Lupfer, HE Ghoneim, J DeBeauchamp, TD Kanneganti, ... Proceedings of the National Academy of Sciences 108 (7), 2927-2932, 2011 | 130 | 2011 |
Functional T cells are capable of supernumerary cell division and longevity AG Soerens, M Künzli, CF Quarnstrom, MC Scott, L Swanson, ... Nature 614 (7949), 762-766, 2023 | 122 | 2023 |
Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes HA Abdelsamed, CC Zebley, H Nguyen, RL Rutishauser, Y Fan, ... Nature immunology 21 (5), 578-587, 2020 | 102 | 2020 |
Fatal outcome of pandemic H1N1 2009 influenza virus infection is associated with immunopathology and impaired lung repair, not enhanced viral burden, in pregnant mice G Marcelin, JR Aldridge, S Duan, HE Ghoneim, J Rehg, H Marjuki, ... Journal of virology 85 (21), 11208-11219, 2011 | 101 | 2011 |
Immunopathogenic and antibacterial effects of H3N2 influenza A virus PB1-F2 map to amino acid residues 62, 75, 79, and 82 IV Alymova, AM Green, N van de Velde, JL McAuley, KL Boyd, ... Journal of virology 85 (23), 12324-12333, 2011 | 95 | 2011 |
Cell-intrinsic barriers of T cell-based immunotherapy HE Ghoneim, AE Zamora, PG Thomas, BA Youngblood Trends in molecular medicine 22 (12), 1000-1011, 2016 | 80 | 2016 |
Adjunctive corticosteroid therapy improves lung immunopathology and survival during severe secondary pneumococcal pneumonia in mice HE Ghoneim, JA McCullers The Journal of infectious diseases 209 (9), 1459-1468, 2014 | 58 | 2014 |
Influenza A virus directly modulates mouse eosinophil responses KS LeMessurier, R Rooney, HE Ghoneim, B Liu, K Li, HS Smallwood, ... Journal of Leucocyte Biology 108 (1), 151-168, 2020 | 56 | 2020 |
Generating long‐lived CD8+ T‐cell memory: Insights from epigenetic programs P Dogra, HE Ghoneim, HA Abdelsamed, B Youngblood European journal of immunology 46 (7), 1548-1562, 2016 | 40 | 2016 |
Rebalancing TGFβ1/BMP signals in exhausted T cells unlocks responsiveness to immune checkpoint blockade therapy AA Saadey, A Yousif, N Osborne, R Shahinfar, YL Chen, B Laster, ... Nature immunology 24 (2), 280-294, 2023 | 25 | 2023 |
Proinflammatory cytokines promote TET2-mediated DNA demethylation during CD8 T cell effector differentiation CC Zebley, HA Abdelsamed, HE Ghoneim, S Alli, C Brown, D Haydar, ... Cell reports 37 (2), 2021 | 25 | 2021 |
Epigenetic remodeling by vitamin C potentiates plasma cell differentiation HY Chen, A Almonte-Loya, FY Lay, M Hsu, E Johnson, ... Elife 11, e73754, 2022 | 17 | 2022 |
Aiolos represses CD4+ T cell cytotoxic programming via reciprocal regulation of TFH transcription factors and IL-2 sensitivity KA Read, DM Jones, S Pokhrel, EDS Hales, A Varkey, JA Tuazon, ... Nature Communications 14 (1), 1652, 2023 | 16 | 2023 |
Gene regulatory circuits in innate and adaptive immune cells A Saini, HE Ghoneim, CWJ Lio, PL Collins, EM Oltz Annual review of immunology 40 (1), 387-411, 2022 | 14 | 2022 |