| MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool H Gad, T Koolmeister, AS Jemth, S Eshtad, SA Jacques, CE Ström, ... Nature 508 (7495), 215-221, 2014 | 568 | 2014 |
| Processing of protein ADP-ribosylation by Nudix hydrolases L Palazzo, B Thomas, AS Jemth, T Colby, O Leidecker, KLH Feijs, R Zaja, ... Biochemical Journal 468 (2), 293-301, 2015 | 161 | 2015 |
| A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family J Carreras-Puigvert, M Zitnik, AS Jemth, M Carter, JE Unterlass, ... Nature communications 8 (1), 1541, 2017 | 158 | 2017 |
| Targeting DNA repair, DNA metabolism and replication stress as anti‐cancer strategies JC Puigvert, K Sanjiv, T Helleday The FEBS journal 283 (2), 232-245, 2016 | 150 | 2016 |
| Diclofenac inhibits tumor necrosis factor‐α‐induced nuclear factor‐κB activation causing synergistic hepatocyte apoptosis L Fredriksson, B Herpers, G Benedetti, Q Matadin, JC Puigvert, H de Bont, ... Hepatology 53 (6), 2027-2041, 2011 | 115 | 2011 |
| Global phosphoproteome profiling reveals unanticipated networks responsive to cisplatin treatment of embryonic stem cells A Pines, CD Kelstrup, MG Vrouwe, JC Puigvert, D Typas, B Misovic, ... Molecular and cellular biology 31 (24), 4964-4977, 2011 | 78 | 2011 |
| The cancer stem cell microenvironment and anti-cancer therapy VPS Ghotra, JC Puigvert, EHJ Danen International Journal of Radiation Biology 85 (11), 955-962, 2009 | 65 | 2009 |
| Integrating cell morphology with gene expression and chemical structure to aid mitochondrial toxicity detection S Seal, J Carreras-Puigvert, MA Trapotsi, H Yang, O Spjuth, A Bender Communications Biology 5 (1), 858, 2022 | 64 | 2022 |
| Hypoxic signaling and the cellular redox tumor environment determine sensitivity to MTH1 inhibition L Bräutigam, L Pudelko, AS Jemth, H Gad, M Narwal, R Gustafsson, ... Cancer research 76 (8), 2366-2375, 2016 | 57 | 2016 |
| The antimalarial drug amodiaquine stabilizes p53 through ribosome biogenesis stress, independently of its autophagy-inhibitory activity JA Espinoza, A Zisi, DC Kanellis, J Carreras-Puigvert, M Henriksson, ... Cell Death & Differentiation 27 (2), 773-789, 2020 | 51 | 2020 |
| The E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest L von Stechow, D Typas, J Carreras Puigvert, L Oort, R Siddappa, A Pines, ... Molecular and cellular biology 35 (7), 1254-1268, 2015 | 51 | 2015 |
| Systems biology approach identifies the kinase Csnk1a1 as a regulator of the DNA damage response in embryonic stem cells J Carreras Puigvert, L von Stechow, R Siddappa, A Pines, M Bahjat, ... Science signaling 6 (259), ra5-ra5, 2013 | 51 | 2013 |
| Silencing of the microtubule-associated proteins doublecortin-like and doublecortin-like kinase-long induces apoptosis in neuroblastoma cells CS Verissimo, JJ Molenaar, J Meerman, JC Puigvert, F Lamers, J Koster, ... Endocrine-Related Cancer 17 (2), 399, 2010 | 48 | 2010 |
| High‐throughput live cell imaging of apoptosis JC Puigvert, H de Bont, B van de Water, EHJ Danen Current protocols in cell biology 47 (1), 18.10. 1-18.10. 13, 2010 | 47 | 2010 |
| A phenomics approach for antiviral drug discovery J Rietdijk, M Tampere, A Pettke, P Georgiev, M Lapins, ... BMC biology 19, 1-15, 2021 | 33 | 2021 |
| Merging bioactivity predictions from cell morphology and chemical fingerprint models using similarity to training data S Seal, H Yang, MA Trapotsi, S Singh, J Carreras-Puigvert, O Spjuth, ... Journal of Cheminformatics 15 (1), 56, 2023 | 32 | 2023 |
| An Open‐Source Modular Framework for Automated Pipetting and Imaging Applications W Ouyang, RW Bowman, H Wang, KE Bumke, JT Collins, O Spjuth, ... Advanced biology 6 (4), 2101063, 2022 | 32 | 2022 |
| Combining molecular and cell painting image data for mechanism of action prediction G Tian, PJ Harrison, AP Sreenivasan, J Carreras-Puigvert, O Spjuth Artificial Intelligence in the Life Sciences 3, 100060, 2023 | 30 | 2023 |
| NOX4 regulates TGFβ‐induced proliferation and self‐renewal in glioblastoma stem cells P García‐Gómez, I Golán, M S. Dadras, A Mezheyeuski, C Bellomo, ... Molecular Oncology 16 (9), 1891-1912, 2022 | 30 | 2022 |
| Cross-talk between integrins and oncogenes modulates chemosensitivity JC Puigvert, S Huveneers, L Fredriksson, M op het Veld, B van de Water, ... Molecular pharmacology 75 (4), 947-955, 2009 | 29 | 2009 |