Time-resolved single-cell transcriptomics defines immune trajectories in glioblastoma D Kirschenbaum, K Xie, F Ingelfinger, Y Katzenelenbogen, K Abadie, ... Cell 187 (1), 149-165. e23, 2024 | 78 | 2024 |
The transcriptional and regulatory identity of erythropoietin producing cells BK Kragesteen, A Giladi, E David, S Halevi, L Geirsdóttir, OM Lempke, ... Nature medicine 29 (5), 1191-1200, 2023 | 47 | 2023 |
Spatial and temporal mapping of breast cancer lung metastases identify TREM2 macrophages as regulators of the metastatic boundary I Yofe, T Shami, N Cohen, T Landsberger, F Sheban, L Stoler-Barak, ... Cancer discovery 13 (12), 2610-2631, 2023 | 38 | 2023 |
Keratinocytes control skin immune homeostasis through de novo–synthesized glucocorticoids TS Phan, L Schink, J Mann, VM Merk, P Zwicky, S Mundt, D Simon, ... Science advances 7 (5), eabe0337, 2021 | 38 | 2021 |
Pharmacological LRH-1/Nr5a2 inhibition limits pro-inflammatory cytokine production in macrophages and associated experimental hepatitis J Schwaderer, T San Phan, A Glöckner, J Delp, M Leist, T Brunner, ... Cell Death & Disease 11 (2), 154, 2020 | 29 | 2020 |
The orphan nuclear receptor LRH-1/NR5a2 critically regulates T cell functions C Seitz, J Huang, AL Geiselhöringer, P Galbani-Bianchi, S Michalek, ... Science advances 5 (7), eaav9732, 2019 | 27 | 2019 |
Liver receptor homolog-1 (NR5a2) regulates CD95/Fas ligand transcription and associated T-cell effector functions J Schwaderer, AK Gaiser, T San Phan, ME Delgado, T Brunner Cell death & disease 8 (4), e2745, 2017 | 27 | 2017 |
Extra-adrenal glucocorticoid synthesis at epithelial barriers T San Phan, VM Merk, T Brunner Genes & Immunity 20, 627-640, 2019 | 26 | 2019 |
IL-12 regulates type 3 immunity through interfollicular keratinocytes in psoriasiform inflammation P Zwicky, F Ingelfinger, BM Silva de Melo, F Ruchti, S Schärli, N Puertas, ... Science immunology 6 (64), eabg9012, 2021 | 20 | 2021 |
Regulation of tissue immune responses by local glucocorticoids at epithelial barriers and their impact on interorgan crosstalk VM Merk, TS Phan, T Brunner Frontiers in Immunology 12, 672808, 2021 | 17 | 2021 |
Liver receptor homolog-1 (NR5A2) orchestrates hepatic inflammation and TNF-induced cell death R Lambrecht, ME Delgado, V Gloe, K Schuetz, AP Plazzo, B Franke, ... Cell Reports 42 (12), 2023 | 10 | 2023 |
Immune escape of colorectal tumours via local LRH‐1/Cyp11b1‐mediated synthesis of immunosuppressive glucocorticoids A Ahmed, C Reinhold, E Breunig, TS Phan, L Dietrich, F Kostadinova, ... Molecular oncology 17 (8), 1545-1566, 2023 | 8 | 2023 |
Non-canonical BIM-regulated energy metabolism determines drug-induced liver necrosis R Lambrecht, F Rudolf, AK Ückert, VC Sladky, TS Phan, J Jansen, S Naim, ... Cell Death & Differentiation 31 (1), 119-131, 2024 | 5 | 2024 |
Local glucocorticoid synthesis regulates house dust mite-induced airway hypersensitivity in mice VM Merk, TS Phan, A Wiedmann, RS Hardy, GG Lavery, T Brunner Frontiers in immunology 14, 1252874, 2023 | 1 | 2023 |
The versatility of liver X receptors in T cell homeostasis: Location, location, location! T San Phan, T Brunner The Journal of experimental medicine 218 (4), e20202318, 2021 | 1 | 2021 |
Liver Receptor Homolog-1 (LRH-1/NR5A2) orchestrates hepatic inflammation and TNF-induced cell death R Lambrecht, M Eugenia Delgado, V Gloe, K Schuetz, AP Plazzo, ... bioRxiv, 2023.05. 24.542039, 2023 | | 2023 |
Lung-derived extra-adrenal glucocorticoids contribute to immune regulation in infectious and allergic diseases VM Merk, TS Phan, DF Legler, T Brunner SWISS MEDICAL WEEKLY 151, 12S-12S, 2021 | | 2021 |