| CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2 X Tai, M Cowan, L Feigenbaum, A Singer Nature immunology 6 (2), 152-162, 2005 | 851 | 2005 |
| Lineage fate and intense debate: myths, models and mechanisms of CD4-versus CD8-lineage choice A Singer, S Adoro, JH Park Nature Reviews Immunology 8 (10), 788-801, 2008 | 699 | 2008 |
| Suppression of IL7Rα transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival JH Park, Q Yu, B Erman, JS Appelbaum, D Montoya-Durango, HL Grimes, ... Immunity 21 (2), 289-302, 2004 | 599 | 2004 |
| Cellular basis of skin allograft rejection: an in vivo model of immune-mediated tissue destruction. AS Rosenberg, A Singer Annual review of immunology 10, 333-358, 1992 | 381 | 1992 |
| Coreceptor reversal in the thymus: signaled CD4+ 8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells E Brugnera, A Bhandoola, R Cibotti, Q Yu, TI Guinter, Y Yamashita, ... Immunity 13 (1), 59-71, 2000 | 371 | 2000 |
| Crosstalk in the mouse thymus W van Ewijk, EW Shores, A Singer Immunology today 15 (5), 214-217, 1994 | 334 | 1994 |
| Negative selection of CD4+ CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28. JA Punt, BA Osborne, Y Takahama, SO Sharrow, A Singer The Journal of experimental medicine 179 (2), 709-713, 1994 | 330 | 1994 |
| Basis of CTLA-4 function in regulatory and conventional CD4+ T cells X Tai, F Van Laethem, L Pobezinsky, T Guinter, SO Sharrow, A Adams, ... Blood, The Journal of the American Society of Hematology 119 (22), 5155-5163, 2012 | 326 | 2012 |
| Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells JH Park, S Adoro, T Guinter, B Erman, AS Alag, M Catalfamo, MY Kimura, ... Nature immunology 11 (3), 257-264, 2010 | 305 | 2010 |
| Phenotype, specificity, and function of T cell subsets and T cell interactions involved in skin allograft rejection. AS Rosenberg, T Mizuochi, SO Sharrow, A Singer Journal of Experimental Medicine 165 (5), 1296-1315, 1987 | 273 | 1987 |
| Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals X Tai, B Erman, A Alag, J Mu, M Kimura, G Katz, T Guinter, T McCaughtry, ... Immunity 38 (6), 1116-1128, 2013 | 270 | 2013 |
| Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: a new perspective on thymic commitment and selection H Suzuki, JA Punt, LG Granger, A Singer Immunity 2 (4), 413-425, 1995 | 268 | 1995 |
| T cell development in mice that lack the ζ chain of the T cell antigen receptor complex PE Love, EW Shores, MD Johnson, ML Tremblay, EJ Lee, A Grinberg, ... Science 261 (5123), 918-921, 1993 | 259 | 1993 |
| Deletion of CD4 and CD8 coreceptors permits generation of αβT cells that recognize antigens independently of the MHC F Van Laethem, SD Sarafova, JH Park, X Tai, L Pobezinsky, TI Guinter, ... Immunity 27 (5), 735-750, 2007 | 236 | 2007 |
| Inhibition of T‐cell receptor beta‐chain gene rearrangement by overexpression of the non‐receptor protein tyrosine kinase p56lck. SJ Anderson, KM Abraham, T Nakayama, A Singer, RM Perlmutter The EMBO journal 11 (13), 4877-4886, 1992 | 234 | 1992 |
| Disorganization and restoration of thymic medullary epithelial cells in T cell receptor‐negative scid mice: evidence that receptor‐bearing lymphocytes influence maturation of … EW Shores, W Van Ewijk, A Singer European journal of immunology 21 (7), 1657-1661, 1991 | 218 | 1991 |
| Regulation of T cell receptor expression in immature CD4+ CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes … DL Wiest, L Yuan, J Jefferson, P Benveniste, M Tsokos, RD Klausner, ... The Journal of experimental medicine 178 (5), 1701-1712, 1993 | 208 | 1993 |
| Clonal deletion and the fate of autoreactive thymocytes that survive negative selection LA Pobezinsky, GS Angelov, X Tai, S Jeurling, F Van Laethem, ... Nature immunology 13 (6), 569-578, 2012 | 205 | 2012 |
| New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision A Singer Current opinion in immunology 14 (2), 207-215, 2002 | 204 | 2002 |
| 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR JH Park, S Adoro, PJ Lucas, SD Sarafova, AS Alag, LL Doan, B Erman, ... Nature immunology 8 (10), 1049-1059, 2007 | 203 | 2007 |
