| From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis B Springthorpe, A Bailey, P Barton, TN Birkinshaw, RV Bonnert, ... Bioorganic & medicinal chemistry letters 17 (21), 6013-6018, 2007 | 301 | 2007 |
| Structural and conformational determinants of macrocycle cell permeability B Over, P Matsson, C Tyrchan, P Artursson, BC Doak, MA Foley, ... Nature Chemical Biology 12 (12), 1065-1074, 2016 | 199 | 2016 |
| Utilization of SABRE-derived hyperpolarization to detect low-concentration analytes via 1D and 2D NMR methods LS Lloyd, RW Adams, M Bernstein, S Coombes, SB Duckett, GGR Green, ... Journal of the American Chemical Society 134 (31), 12904-12907, 2012 | 138 | 2012 |
| Hyperpolarisation through reversible interactions with para hydrogen LS Lloyd, A Asghar, MJ Burns, A Charlton, S Coombes, MJ Cowley, ... Catalysis science & technology 4 (10), 3544-3554, 2014 | 109 | 2014 |
| Optimization of monocarboxylate transporter 1 blockers through analysis and modulation of atropisomer interconversion properties SD Guile, JR Bantick, ME Cooper, DK Donald, C Eyssade, AH Ingall, ... Journal of medicinal chemistry 50 (2), 254-263, 2007 | 70 | 2007 |
| Discovery of a potent and selective oral inhibitor of ERK1/2 (AZD0364) that is efficacious in both monotherapy and combination therapy in models of nonsmall cell lung cancer … RA Ward, MJ Anderton, P Bethel, J Breed, C Cook, EJ Davies, A Dobson, ... Journal of medicinal chemistry 62 (24), 11004-11018, 2019 | 63 | 2019 |
| A comparison of capillary‐scale LC–NMR with alternative techniques: spectroscopic and practical considerations RJ Lewis, MA Bernstein, SJ Duncan, CJ Sleigh Magnetic Resonance in Chemistry 43 (9), 783-789, 2005 | 63 | 2005 |
| Structure-guided discovery of potent and selective inhibitors of ERK1/2 from a modestly active and promiscuous chemical start point RA Ward, P Bethel, C Cook, E Davies, JE Debreczeni, G Fairley, L Feron, ... Journal of medicinal chemistry 60 (8), 3438-3450, 2017 | 58 | 2017 |
| Impact of excited-state antiaromaticity relief in a fundamental benzene photoreaction leading to substituted bicyclo [3.1. 0] hexenes T Slanina, R Ayub, J Toldo, J Sundell, W Rabten, M Nicaso, I Alabugin, ... Journal of the American Chemical Society 142 (25), 10942-10954, 2020 | 46 | 2020 |
| The importance of ion-pairing in peptide purification by reversed-phase liquid chromatography D Åsberg, AL Weinmann, T Leek, RJ Lewis, M Klarqvist, M Leśko, ... Journal of Chromatography A 1496, 80-91, 2017 | 46 | 2017 |
| Selective excitation of overlapping multiplets; the application of doubly selective and chemical shift filter experiments to complex NMR spectra SJ Duncan, R Lewis, MA Bernstein, P Sandor Magnetic Resonance in Chemistry 45 (4), 283-288, 2007 | 34 | 2007 |
| Saccharin Aza Bioisosteres Synthesis and Preclinical Property Comparisons Y Chen, CJ Aurell, A Pettersen, RJ Lewis, MA Hayes, M Lepistö, ... ACS Medicinal Chemistry Letters 8 (6), 672-677, 2017 | 32 | 2017 |
| Synthesis and Evaluation of the First Fluorescent Antagonists of the Human P2Y2 Receptor Based on AR-C118925 S Conroy, ND Kindon, J Glenn, LA Stoddart, RJ Lewis, SJ Hill, B Kellam, ... Journal of medicinal chemistry 61 (7), 3089-3113, 2018 | 29 | 2018 |
| Complex Polyheterocycles and the Stereochemical Reassignment of Pileamartine A via Aza-Heck Triggered Aryl C–H Functionalization Cascades BT Jones, J García-Cárceles, L Caiger, IR Hazelden, RJ Lewis, T Langer, ... Journal of the American Chemical Society 143 (38), 15593-15598, 2021 | 26 | 2021 |
| Structure–activity studies on amides inhibiting photosystem II RJ Lewis, P Camilleri, AJ Kirby, CA Marby, AA Slawin, DJ Williams Journal of the Chemical Society, Perkin Transactions 2, 1625-1630, 1991 | 26 | 1991 |
| Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1–Nrf2 Protein–Protein Interaction F Begnini, S Geschwindner, P Johansson, L Wissler, RJ Lewis, ... Journal of medicinal chemistry 65 (4), 3473-3517, 2022 | 24 | 2022 |
| Identification and optimization of pyrrolidine derivatives as highly potent ghrelin receptor full agonists M Cooper, A Llinas, P Hansen, M Caffrey, A Ray, S Sjödin, I Shamovsky, ... Journal of Medicinal Chemistry 63 (17), 9705-9730, 2020 | 20 | 2020 |
| Which hydroxy? Evidence for species differences in the regioselectivity of glucuronidation in rat, dog, and human in vitro systems and dog in vivo IJ Martin, RJ Lewis, MA Bernstein, IG Beattie, CA Martin, RJ Riley, ... Drug metabolism and disposition 34 (9), 1502-1507, 2006 | 16 | 2006 |
| Late-occurring and long-circulating metabolites of GABAAα2, 3 receptor modulator AZD7325 involving metabolic cyclization and aromatization: Relevance to MIST analysis and … C Gu, M Artelsmair, CS Elmore, RJ Lewis, P Davis, JE Hall, ... Drug Metabolism and Disposition 46 (3), 303-315, 2018 | 15 | 2018 |
| Discovery of pyrazoles as novel FPR1 antagonists AD Morley, A Cook, S King, B Roberts, S Lever, R Weaver, C MacDonald, ... Bioorganic & medicinal chemistry letters 21 (21), 6456-6460, 2011 | 14 | 2011 |
Michael BernsteinAmber Analytical Servicesכתובת אימייל מאומתת בדומיין AMBERANALYTICAL.COM
