| Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity A Zhernakova, A Kurilshikov, MJ Bonder, EF Tigchelaar, M Schirmer, ... Science 352 (6285), 565-569, 2016 | 1923 | 2016 |
| Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression U Võsa, A Claringbould, HJ Westra, MJ Bonder, P Deelen, B Zeng, ... Nature genetics 53 (9), 1300-1310, 2021 | 1210 | 2021 |
| Mapping the human genetic architecture of COVID-19 Writing group Writing group leaders Pathak Gita A. 6 Andrews Shea J. 7 Kanai ... Nature 600 (7889), 472-477, 2021 | 846 | 2021 |
| The effect of host genetics on the gut microbiome MJ Bonder, A Kurilshikov, EF Tigchelaar, Z Mujagic, F Imhann, AV Vila, ... Nature genetics 48 (11), 1407-1412, 2016 | 832 | 2016 |
| Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes A Xue, Y Wu, Z Zhu, F Zhang, KE Kemper, Z Zheng, L Yengo, ... Nature communications 9 (1), 2941, 2018 | 812 | 2018 |
| Whole-genome sequence variation, population structure and demographic history of the Dutch population Nature genetics 46 (8), 818-825, 2014 | 746 | 2014 |
| Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences R Karlsson Linnér, P Biroli, E Kong, SFW Meddens, R Wedow, ... Nature genetics 51 (2), 245-257, 2019 | 700 | 2019 |
| Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis U Võsa, A Claringbould, HJ Westra, MJ Bonder, P Deelen, B Zeng, ... biorxiv, 447367, 2018 | 508 | 2018 |
| Disease variants alter transcription factor levels and methylation of their binding sites MJ Bonder, R Luijk, DV Zhernakova, M Moed, P Deelen, M Vermaat, ... Nature genetics 49 (1), 131-138, 2017 | 506 | 2017 |
| Identification of context-dependent expression quantitative trait loci in whole blood DV Zhernakova, P Deelen, M Vermaat, M Van Iterson, M Van Galen, ... Nature genetics 49 (1), 139-145, 2017 | 489 | 2017 |
| Trans-eQTLs Reveal That Independent Genetic Variants Associated with a Complex Phenotype Converge on Intermediate Genes, with a Major Role for the HLA RSN Fehrmann, RC Jansen, JH Veldink, HJ Westra, D Arends, ... PLoS genetics 7 (8), e1002197, 2011 | 443 | 2011 |
| Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology W Van Rheenen, RAA Van Der Spek, MK Bakker, JJFA Van Vugt, PJ Hop, ... Nature genetics 53 (12), 1636-1648, 2021 | 400 | 2021 |
| Single-cell RNA sequencing identifies celltype-specific cis-eQTLs and co-expression QTLs MGP Van Der Wijst, H Brugge, DH De Vries, P Deelen, MA Swertz, ... Nature genetics 50 (4), 493-497, 2018 | 375 | 2018 |
| Controlling bias and inflation in epigenome-and transcriptome-wide association studies using the empirical null distribution M van Iterson, EW van Zwet, Bios Consortium, BT Heijmans Genome biology 18, 1-13, 2017 | 345 | 2017 |
| A functional genomics approach to understand variation in cytokine production in humans Y Li, M Oosting, SP Smeekens, M Jaeger, R Aguirre-Gamboa, KTT Le, ... Cell 167 (4), 1099-1110. e14, 2016 | 344 | 2016 |
| The Genome of the Netherlands: design, and project goals DI Boomsma, C Wijmenga, EP Slagboom, MA Swertz, LC Karssen, ... European journal of human genetics 22 (2), 221-227, 2014 | 338 | 2014 |
| Whole-genome sequencing reveals host factors underlying critical COVID-19 A Kousathanas, E Pairo-Castineira, K Rawlik, A Stuckey, CA Odhams, ... Nature 607 (7917), 97-103, 2022 | 307 | 2022 |
| Genetic insights into biological mechanisms governing human ovarian ageing KS Ruth, FR Day, J Hussain, A Martínez-Marchal, CE Aiken, A Azad, ... Nature 596 (7872), 393-397, 2021 | 306 | 2021 |
| Cohort profile: LifeLines DEEP, a prospective, general population cohort study in the northern Netherlands: study design and baseline characteristics EF Tigchelaar, A Zhernakova, JAM Dekens, G Hermes, A Baranska, ... BMJ open 5 (8), e006772, 2015 | 302 | 2015 |
| Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression J Fu, MGM Wolfs, P Deelen, HJ Westra, RSN Fehrmann, GJ Te Meerman, ... PLoS genetics 8 (1), e1002431, 2012 | 279 | 2012 |
Lude FrankeProfessor of Functional Genomics, University Medical Centre Groningenכתובת אימייל מאומתת בדומיין cleverfranke.com