| New 4-point pharmacophore method for molecular similarity and diversity applications: overview of the method and applications, including a novel approach to the design of … JS Mason, I Morize, PR Menard, DL Cheney, C Hulme, RF Labaudiniere Journal of medicinal chemistry 42 (17), 3251-3264, 1999 | 520 | 1999 |
| Macrocycle conformational sampling with MacroModel KS Watts, P Dalal, AJ Tebben, DL Cheney, JC Shelley Journal of chemical information and modeling 54 (10), 2680-2696, 2014 | 166 | 2014 |
| Factor Xa inhibitors: next-generation antithrombotic agents DJP Pinto, JM Smallheer, DL Cheney, RM Knabb, RR Wexler Journal of medicinal chemistry 53 (17), 6243-6274, 2010 | 162 | 2010 |
| Improving accuracy, diversity, and speed with prime macrocycle conformational sampling D Sindhikara, SA Spronk, T Day, K Borrelli, DL Cheney, SL Posy Journal of chemical information and modeling 57 (8), 1881-1894, 2017 | 112 | 2017 |
| Identification of novel and potent isoquinoline aminooxazole-based IMPDH inhibitors P Chen, D Norris, KD Haslow, TGM Dhar, WJ Pitts, SH Watterson, ... Bioorganic & medicinal chemistry letters 13 (7), 1345-1348, 2003 | 83 | 2003 |
| Optimization of the β-Aminoester class of factor Xa inhibitors. part 2: Identification of FXV673 as a potent and selective inhibitor with excellent In vivo anticoagulant activity KR Guertin, CJ Gardner, SI Klein, AL Zulli, M Czekaj, Y Gong, AP Spada, ... Bioorganic & medicinal chemistry letters 12 (12), 1671-1674, 2002 | 74 | 2002 |
| The synthesis and SAR of new 4-(N-alkyl-N-phenyl) amino-6, 7-dimethoxyquinazolines and 4-(N-alkyl-N-phenyl) aminopyrazolo [3, 4-d] pyrimidines, inhibitors of CSF-1R tyrosine … MR Myers, NN Setzer, AP Spada, PE Persons, CQ Ly, MP Maguire, ... Bioorganic & Medicinal Chemistry Letters 7 (4), 421-424, 1997 | 73 | 1997 |
| AP-Net: An atomic-pairwise neural network for smooth and transferable interaction potentials ZL Glick, DP Metcalf, A Koutsoukas, SA Spronk, DL Cheney, CD Sherrill The Journal of Chemical Physics 153 (4), 2020 | 70 | 2020 |
| Discovery and Development of 5-[(5S,9R)-9- (4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1- methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non- 7-yl-methyl]-3 … D Potin, M Launay, F Monatlik, P Malabre, M Fabreguettes, A Fouquet, ... Journal of medicinal chemistry 49 (24), 6946-6949, 2006 | 68 | 2006 |
| Identification and initial structure− activity relationships of a novel class of nonpeptide inhibitors of blood coagulation factor Xa SI Klein, M Czekaj, CJ Gardner, KR Guertin, DL Cheney, AP Spada, ... Journal of medicinal chemistry 41 (4), 437-450, 1998 | 68 | 1998 |
| Library design and virtual screening using multiple 4-point pharmacophore fingerprints JS Mason, DL Cheney Biocomputing 2000, 576-587, 1999 | 67 | 1999 |
| Design and structure− activity relationships of potent and selective inhibitors of blood coagulation factor Xa WR Ewing, MR Becker, VE Manetta, RS Davis, HW Pauls, H Mason, ... Journal of medicinal chemistry 42 (18), 3557-3571, 1999 | 64 | 1999 |
| Achieving structural diversity using the perpendicular conformation of alpha-substituted phenylcyclopropanes to mimic the bioactive conformation of ortho-substituted biphenyl … JX Qiao, DL Cheney, RS Alexander, AM Smallwood, SR King, K He, ... Bioorganic & medicinal chemistry letters 18 (14), 4118-4123, 2008 | 61 | 2008 |
| Sulfonamidopyrrolidinone factor Xa inhibitors: potency and selectivity enhancements via P-1 and P-4 optimization YM Choi-Sledeski, DG McGarry, DM Green, HJ Mason, MR Becker, ... Journal of medicinal chemistry 42 (18), 3572-3587, 1999 | 57 | 1999 |
| Discovery of N-[2-[2-[[3-Methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methyl-4- morpholineacetamide as a Novel and Potent Inhibitor of Inosine … TGM Dhar, Z Shen, J Guo, C Liu, SH Watterson, HH Gu, WJ Pitts, ... Journal of medicinal chemistry 45 (11), 2127-2130, 2002 | 56 | 2002 |
| Analysis and optimization of structure-based virtual screening protocols: 2. Examination of docked ligand orientation sampling methodology: mapping a pharmacophore for success AC Good, DL Cheney, DF Sitkoff, JS Tokarski, TR Stouch, DA Bassolino, ... Journal of Molecular Graphics and Modelling 22 (1), 31-40, 2003 | 49 | 2003 |
| Rapid synthesis of triazine inhibitors of inosine monophosphate dehydrogenase WJ Pitts, J Guo, TGM Dhar, Z Shen, HH Gu, SH Watterson, MS Bednarz, ... Bioorganic & medicinal chemistry letters 12 (16), 2137-2140, 2002 | 47 | 2002 |
| Atropisomer control in macrocyclic factor VIIa inhibitors PW Glunz, L Mueller, DL Cheney, V Ladziata, Y Zou, NR Wurtz, A Wei, ... Journal of Medicinal Chemistry 59 (8), 4007-4018, 2016 | 42 | 2016 |
| Structure–activity relationships of anthranilamide-based factor Xa inhibitors containing piperidinone and pyridinone P4 moieties JR Corte, T Fang, DJP Pinto, W Han, Z Hu, XJ Jiang, YL Li, JF Gauuan, ... Bioorganic & medicinal chemistry letters 18 (9), 2845-2849, 2008 | 42 | 2008 |
| Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series SH Watterson, M Carlsen, TGM Dhar, Z Shen, WJ Pitts, J Guo, HH Gu, ... Bioorganic & medicinal chemistry letters 13 (3), 543-546, 2003 | 42 | 2003 |