MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas N Mäkinen, M Mehine, J Tolvanen, E Kaasinen, Y Li, HJ Lehtonen, ... Science 334 (6053), 252-255, 2011 | 777 | 2011 |
Characterization of uterine leiomyomas by whole-genome sequencing M Mehine, E Kaasinen, N Mäkinen, R Katainen, K Kämpjärvi, E Pitkänen, ... New England Journal of Medicine 369 (1), 43-53, 2013 | 372 | 2013 |
Integrated data analysis reveals uterine leiomyoma subtypes with distinct driver pathways and biomarkers M Mehine, E Kaasinen, HR Heinonen, N Mäkinen, K Kämpjärvi, ... Proceedings of the National Academy of Sciences 113 (5), 1315-1320, 2016 | 227 | 2016 |
Genomics of uterine leiomyomas: insights from high-throughput sequencing M Mehine, N Mäkinen, HR Heinonen, LA Aaltonen, P Vahteristo Fertility and sterility 102 (3), 621-629, 2014 | 217 | 2014 |
Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer K Kämpjärvi, N Mäkinen, O Kilpivaara, J Arola, HR Heinonen, J Böhm, ... British journal of cancer 107 (10), 1761-1765, 2012 | 128 | 2012 |
AIP inactivation leads to pituitary tumorigenesis through defective Gαi-cAMP signaling I Tuominen, E Heliövaara, A Raitila, MR Rautiainen, M Mehine, ... Oncogene 34 (9), 1174-1184, 2015 | 122 | 2015 |
Mutations in Exon 1 Highlight the Role of MED12 in Uterine Leiomyomas K Kämpjärvi, MJ Park, M Mehine, NH Kim, AD Clark, R Bützow, T Böhling, ... Human mutation 35 (9), 1136-1141, 2014 | 93 | 2014 |
Deficient H2A. Z deposition is associated with genesis of uterine leiomyoma DG Berta, H Kuisma, N Välimäki, M Räisänen, M Jäntti, A Pasanen, ... Nature 596 (7872), 398-403, 2021 | 77 | 2021 |
Germline-focused analysis of tumour-detected variants in 49,264 cancer patients: ESMO Precision Medicine Working Group recommendations Z Kuzbari, C Bandlamudi, C Loveday, A Garrett, M Mehine, A George, ... Annals of Oncology 34 (3), 215-227, 2023 | 62 | 2023 |
MED12 mutations and FH inactivation are mutually exclusive in uterine leiomyomas K Kämpjärvi, N Mäkinen, M Mehine, S Välipakka, O Uimari, E Pitkänen, ... British journal of cancer 114 (12), 1405-1411, 2016 | 57 | 2016 |
Genetic ancestry correlates with somatic differences in a real-world clinical cancer sequencing cohort K Arora, TN Tran, Y Kemel, M Mehine, YL Liu, S Nandakumar, SA Smith, ... Cancer discovery 12 (11), 2552-2565, 2022 | 46 | 2022 |
Global metabolomic profiling of uterine leiomyomas HR Heinonen, M Mehine, N Mäkinen, A Pasanen, E Pitkänen, A Karhu, ... British journal of cancer 117 (12), 1855-1864, 2017 | 45 | 2017 |
Clonally related uterine leiomyomas are common and display branched tumor evolution M Mehine, HR Heinonen, N Sarvilinna, E Pitkänen, N Mäkinen, ... Human molecular genetics 24 (15), 4407-4416, 2015 | 35 | 2015 |
Origin of uterine fibroids: conversion of myometrial stem cells to tumor-initiating cells H Elkafas, Y Qiwei, A Al-Hendy Seminars in reproductive medicine 35 (06), 481-486, 2017 | 29 | 2017 |
Chromothripsis in uterine leiomyomas. DN Markowski, J Bullerdiek The New England journal of medicine 369 (22), 2160-2160, 2013 | 19 | 2013 |
MIPUP: minimum perfect unmixed phylogenies for multi-sampled tumors via branchings and ILP E Husić, X Li, A Hujdurović, M Mehine, R Rizzi, V Mäkinen, M Milanič, ... Bioinformatics 35 (5), 769-777, 2019 | 15 | 2019 |
NBN Pathogenic Germline Variants are Associated with Pan-Cancer Susceptibility and In Vitro DNA Damage Response Defects S Belhadj, A Khurram, C Bandlamudi, G Palou-Márquez, V Ravichandran, ... Clinical Cancer Research 29 (2), 422-431, 2023 | 14 | 2023 |
Expanded genetic testing of GIST patients identifies high proportion of non-syndromic patients with germline alterations D Mandelker, A Marra, N Mehta, P Selenica, Z Yelskaya, C Yang, J Somar, ... NPJ Precision Oncology 7 (1), 1, 2023 | 14 | 2023 |
A novel uterine leiomyoma subtype exhibits NRF2 activation and mutations in genes associated with neddylation of the Cullin 3-RING E3 ligase M Mehine, T Ahvenainen, S Khamaiseh, J Härkönen, S Reinikka, ... Oncogenesis 11 (1), 52, 2022 | 13 | 2022 |
3′ RNA sequencing accurately classifies formalin-fixed paraffin-embedded uterine leiomyomas M Mehine, S Khamaiseh, T Ahvenainen, T Heikkinen, A Äyräväinen, ... Cancers 12 (12), 3839, 2020 | 11 | 2020 |