| Cyclic [G (2′, 5′) pA (3′, 5′) p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase P Gao, M Ascano, Y Wu, W Barchet, BL Gaffney, T Zillinger, AA Serganov, ... Cell 153 (5), 1094-1107, 2013 | 1075 | 2013 |
| Structure-function analysis of STING activation by c [G (2′, 5′) pA (3′, 5′) p] and targeting by antiviral DMXAA P Gao, M Ascano, T Zillinger, W Wang, P Dai, AA Serganov, BL Gaffney, ... Cell 154 (4), 748-762, 2013 | 597 | 2013 |
| Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice J Vincent, C Adura, P Gao, A Luz, L Lama, Y Asano, R Okamoto, ... Nature communications 8 (1), 750, 2017 | 292 | 2017 |
| PAM-dependent target DNA recognition and cleavage by C2c1 CRISPR-Cas endonuclease H Yang, P Gao, KR Rajashankar, DJ Patel Cell 167 (7), 1814-1828. e12, 2016 | 275 | 2016 |
| Type V CRISPR-Cas Cpf1 endonuclease employs a unique mechanism for crRNA-mediated target DNA recognition P Gao, H Yang, KR Rajashankar, Z Huang, DJ Patel Cell research 26 (8), 901-913, 2016 | 251 | 2016 |
| Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression L Lama, C Adura, W Xie, D Tomita, T Kamei, V Kuryavyi, T Gogakos, ... Nature Communications 10 (1), 2261, 2019 | 202 | 2019 |
| Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome C Shen, R Li, R Negro, J Cheng, SM Vora, TM Fu, A Wang, K He, ... Cell 184 (23), 5759-5774. e20, 2021 | 165 | 2021 |
| DNA sensor cGAS-mediated immune recognition P Xia, S Wang, P Gao, G Gao, Z Fan Protein & cell 7 (11), 777-791, 2016 | 139 | 2016 |
| Molecular mechanism of RNA recognition by zinc-finger antiviral protein X Luo, X Wang, Y Gao, J Zhu, S Liu, G Gao, P Gao Cell reports 30 (1), 46-52. e4, 2020 | 129 | 2020 |
| Regulation of HIV-1 Gag-Pol expression by shiftless, an inhibitor of programmed-1 ribosomal frameshifting X Wang, Y Xuan, Y Han, X Ding, K Ye, F Yang, P Gao, SP Goff, G Gao Cell 176 (3), 625-635. e14, 2019 | 123 | 2019 |
| SMARCA3, a chromatin-remodeling factor, is required for p11-dependent antidepressant action YS Oh, P Gao, KW Lee, I Ceglia, JS Seo, X Zhang, JH Ahn, BT Chait, ... Cell 152 (4), 831-843, 2013 | 119 | 2013 |
| Binding-pocket and lid-region substitutions render human STING sensitive to the species-specific drug DMXAA P Gao, T Zillinger, W Wang, M Ascano, P Dai, G Hartmann, T Tuschl, ... Cell reports 8 (6), 1668-1676, 2014 | 108 | 2014 |
| Diverse mechanisms of CRISPR-Cas9 inhibition by type IIC anti-CRISPR proteins Y Zhu, A Gao, Q Zhan, Y Wang, H Feng, S Liu, G Gao, A Serganov, P Gao Molecular cell 74 (2), 296-309. e7, 2019 | 107 | 2019 |
| Creatine promotes cancer metastasis through activation of Smad2/3 L Zhang, Z Zhu, H Yan, W Wang, Z Wu, F Zhang, Q Zhang, G Shi, J Du, ... Cell metabolism 33 (6), 1111-1123. e4, 2021 | 98 | 2021 |
| Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion G Xu, C Liu, S Zhou, Q Li, Y Feng, P Sun, H Feng, Y Gao, J Zhu, X Luo, ... Molecular cell 81 (13), 2823-2837. e9, 2021 | 90 | 2021 |
| Pistol ribozyme adopts a pseudoknot fold facilitating site-specific in-line cleavage A Ren, N Vušurović, J Gebetsberger, P Gao, M Juen, C Kreutz, R Micura, ... Nature chemical biology 12 (9), 702-708, 2016 | 90 | 2016 |
| Structural insights into non-canonical ubiquitination catalyzed by SidE Y Wang, M Shi, H Feng, Y Zhu, S Liu, A Gao, P Gao Cell 173 (5), 1231-1243. e16, 2018 | 68 | 2018 |
| Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2 S Sun, Y Cai, TZ Song, Y Pu, L Cheng, H Xu, J Sun, C Meng, Y Lin, ... Cell Research 31 (9), 1011-1023, 2021 | 64 | 2021 |
| Compositions and methods for altering second messenger signaling D Patel, T Tuschl, M Ascano, Y Wu, Y Liu, W Barchet, G Hartmann, ... US Patent 9,840,533, 2017 | 60 | 2017 |
| Gao R Gao, M Ascano, T Zillinger, W Wang, P Dai, AA Serganov, BL Gaffney, ... Piatkevich KD, Neve RL, Upadhyayula S, Boyden ES, 2019 | 39 | 2019 |