Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ... autophagy 17 (1), 1-382, 2021 | 11255 | 2021 |
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak SN Willis, JI Fletcher, T Kaufmann, MF van Delft, L Chen, PE Czabotar, ... Science 315 (5813), 856-859, 2007 | 1478 | 2007 |
Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis PE Czabotar, D Westphal, G Dewson, S Ma, C Hockings, WD Fairlie, ... Cell 152 (3), 519-531, 2013 | 667 | 2013 |
Structural insights into the degradation of Mcl-1 induced by BH3 domains PE Czabotar, EF Lee, MF van Delft, CL Day, BJ Smith, DCS Huang, ... Proceedings of the National Academy of Sciences 104 (15), 6217-6222, 2007 | 525 | 2007 |
Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia SP Glaser, EF Lee, E Trounson, P Bouillet, A Wei, WD Fairlie, DJ Izon, ... Genes & development 26 (2), 120-125, 2012 | 474 | 2012 |
Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family EF Lee, PE Czabotar, BJ Smith, K Deshayes, K Zobel, PM Colman, ... Cell Death & Differentiation 14 (9), 1711-1713, 2007 | 340 | 2007 |
TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (TNF) to efficiently activate NF-κB and to prevent TNF-induced apoptosis JE Vince, D Pantaki, R Feltham, PD Mace, SM Cordier, AC Schmukle, ... Journal of Biological Chemistry 284 (51), 35906-35915, 2009 | 272 | 2009 |
Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1 CL Day, C Smits, FC Fan, EF Lee, WD Fairlie, MG Hinds Journal of molecular biology 380 (5), 958-971, 2008 | 261 | 2008 |
Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax JI Fletcher, S Meusburger, CJ Hawkins, DT Riglar, EF Lee, WD Fairlie, ... Proceedings of the National Academy of Sciences 105 (47), 18081-18087, 2008 | 236 | 2008 |
The role of BH3-only protein Bim extends beyond inhibiting Bcl-2–like prosurvival proteins D Mérino, M Giam, PD Hughes, OM Siggs, K Heger, LA O'Reilly, ... Journal of Cell Biology 186 (3), 355-362, 2009 | 235 | 2009 |
Bcl-2, Bcl-xL, and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells D Mérino, SL Khaw, SP Glaser, DJ Anderson, LD Belmont, C Wong, ... Blood, The Journal of the American Society of Hematology 119 (24), 5807-5816, 2012 | 234 | 2012 |
A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation EF Lee, PE Czabotar, MF Van Delft, EM Michalak, MJ Boyle, SN Willis, ... The Journal of cell biology 180 (2), 341-355, 2008 | 193 | 2008 |
Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53 GL Kelly, S Grabow, SP Glaser, L Fitzsimmons, BJ Aubrey, T Okamoto, ... Genes & development 28 (1), 58-70, 2014 | 189 | 2014 |
High‐Resolution Structural Characterization of a Helical α/β‐Peptide Foldamer Bound to the Anti‐Apoptotic Protein Bcl‐xL EF Lee, JD Sadowsky, BJ Smith, PE Czabotar, KJ Peterson‐Kaufman, ... Angewandte Chemie International Edition 48 (24), 4318-4322, 2009 | 187 | 2009 |
BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival EF Lee, TJ Harris, S Tran, M Evangelista, S Arulananda, T John, ... Cell death & disease 10 (5), 342, 2019 | 179 | 2019 |
Evaluation of diverse α/β-backbone patterns for functional α-helix mimicry: analogues of the Bim BH3 domain MD Boersma, HS Haase, KJ Peterson-Kaufman, EF Lee, OB Clarke, ... Journal of the American Chemical Society 134 (1), 315-323, 2012 | 173 | 2012 |
A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak M Kvansakul, MF van Delft, EF Lee, JM Gulbis, WD Fairlie, DCS Huang, ... Molecular cell 25 (6), 933-942, 2007 | 149 | 2007 |
BECLIN1: protein structure, function and regulation S Tran, WD Fairlie, EF Lee Cells 10 (6), 1522, 2021 | 143 | 2021 |
Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis PE Czabotar, EF Lee, GV Thompson, AZ Wardak, WD Fairlie, PM Colman Journal of Biological Chemistry 286 (9), 7123-7131, 2011 | 143 | 2011 |
α/β-Peptide foldamers targeting intracellular protein–protein interactions with activity in living cells JW Checco, EF Lee, M Evangelista, NJ Sleebs, K Rogers, ... Journal of the American Chemical Society 137 (35), 11365-11375, 2015 | 142 | 2015 |