Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use M Liu, Y Jiang, R Wedow, 23andMe Research Team Nat Genet 51 (2), 237-244, 2019 | 1743 | 2019 |
The power of genetic diversity in genome-wide association studies of lipids SE Graham, SL Clarke, KHH Wu, S Kanoni, GJM Zajac, S Ramdas, ... Nature 600 (7890), 675-679, 2021 | 627 | 2021 |
Complex genetic signatures in immune cells underlie autoimmunity and inform therapy V Orrù, M Steri, C Sidore, M Marongiu, V Serra, S Olla, G Sole, S Lai, ... Nature genetics 52 (10), 1036-1045, 2020 | 617 | 2020 |
Overexpression of the cytokine BAFF and autoimmunity risk M Steri, V Orrù, ML Idda, M Pitzalis, M Pala, I Zara, C Sidore, V Faà, ... New England Journal of Medicine 376 (17), 1615-1626, 2017 | 409 | 2017 |
Genetic variants regulating immune cell levels in health and disease V Orrù, M Steri, G Sole, C Sidore, F Virdis, M Dei, S Lai, M Zoledziewska, ... Cell 155 (1), 242-256, 2013 | 399 | 2013 |
Genetic diversity fuels gene discovery for tobacco and alcohol use GRB Saunders, X Wang, F Chen, SK Jang, M Liu, C Wang, S Gao, ... Nature 612 (7941), 720-724, 2022 | 274 | 2022 |
The longitudinal dynamics and natural history of clonal haematopoiesis MA Fabre, JG de Almeida, E Fiorillo, E Mitchell, A Damaskou, J Rak, ... Nature 606 (7913), 335-342, 2022 | 267 | 2022 |
Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation A Teumer, L Chaker, S Groeneweg, Y Li, C Di Munno, C Barbieri, ... Nature communications 9 (1), 4455, 2018 | 260 | 2018 |
A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus V Orru, SJ Tsai, B Rueda, E Fiorillo, SM Stanford, J Dasgupta, J Hartiala, ... Human molecular genetics 18 (3), 569-579, 2009 | 155 | 2009 |
Potential and active functions in the gut microbiota of a healthy human cohort A Tanca, M Abbondio, A Palomba, C Fraumene, V Manghina, F Cucca, ... Microbiome 5, 1-15, 2017 | 152 | 2017 |
Gold (I)-mediated inhibition of protein tyrosine phosphatases: a detailed in vitro and cellular study D Krishnamurthy, MR Karver, E Fiorillo, V Orru, SM Stanford, N Bottini, ... Journal of medicinal chemistry 51 (15), 4790-4795, 2008 | 150 | 2008 |
Autoimmune-associated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residue E Fiorillo, V Orru, SM Stanford, Y Liu, M Salek, N Rapini, AD Schenone, ... Journal of biological chemistry 285 (34), 26506-26518, 2010 | 124 | 2010 |
A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration PS De Vries, DI Chasman, M Sabater-Lleal, MH Chen, JE Huffman, ... Human molecular genetics 25 (2), 358-370, 2016 | 100 | 2016 |
Crystal structure of the human lymphoid tyrosine phosphatase catalytic domain: insights into redox regulation SJ Tsai, U Sen, L Zhao, WB Greenleaf, J Dasgupta, E Fiorillo, V Orrú, ... Biochemistry 48 (22), 4838-4845, 2009 | 61 | 2009 |
Depressive symptoms, thyroid hormone and autoimmunity in a population-based cohort from Sardinia AP Delitala, A Terracciano, E Fiorillo, V Orrù, D Schlessinger, F Cucca Journal of affective disorders 191, 82-87, 2016 | 56 | 2016 |
Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection SK Ahuja, MS Manoharan, GC Lee, LR McKinnon, JA Meunier, M Steri, ... Nature communications 14 (1), 3286, 2023 | 55 | 2023 |
Population-and individual-specific regulatory variation in Sardinia M Pala, Z Zappala, M Marongiu, X Li, JR Davis, R Cusano, F Crobu, ... Nature genetics 49 (5), 700-707, 2017 | 54 | 2017 |
Effect of different disease-modifying therapies on humoral response to BNT162b2 vaccine in Sardinian multiple sclerosis patients M Pitzalis, ML Idda, V Lodde, A Loizedda, M Lobina, M Zoledziewska, ... Frontiers in immunology 12, 781843, 2021 | 47 | 2021 |
Kidney size in relation to ageing, gender, renal function, birthweight and chronic kidney disease risk factors in a general population D Piras, M Masala, A Delitala, SAM Urru, N Curreli, L Balaci, LP Ferreli, ... Nephrology Dialysis Transplantation 35 (4), 640-647, 2020 | 47 | 2020 |
CXCR3 identifies human naive CD8+ T cells with enhanced effector differentiation potential G De Simone, E Mazza, A Cassotta, AN Davydov, M Kuka, V Zanon, ... The Journal of Immunology 203 (12), 3179-3189, 2019 | 47 | 2019 |