| Epigenetic modifications: basic mechanisms and role in cardiovascular disease DE Handy, R Castro, J Loscalzo Circulation 123 (19), 2145-2156, 2011 | 1138 | 2011 |
| Increased Homocysteine and S-Adenosylhomocysteine Concentrations and DNA Hypomethylation in Vascular Disease R Castro, I Rivera, EA Struys, EEW Jansen, P Ravasco, ME Camilo, ... Clinical chemistry 49 (8), 1292-1296, 2003 | 531 | 2003 |
| Homocysteine metabolism, hyperhomocysteinaemia and vascular disease: an overview R Castro, I Rivera, HJ Blom, C Jakobs, IT De Almeida Journal of Inherited Metabolic Disease: Official Journal of the Society for …, 2006 | 406 | 2006 |
| The contribution of homocysteine metabolism disruption to endothelial dysfunction: state-of-the-art R Esse, M Barroso, I Tavares de Almeida, R Castro International journal of molecular sciences 20 (4), 867, 2019 | 335 | 2019 |
| 5, 10-methylenetetrahydrofolate reductase (MTHFR) 677C→ T and 1298A→ C mutations are associated with DNA hypomethylation R Castro, I Rivera, P Ravasco, ME Camilo, C Jakobs, HJ Blom, ... Journal of medical genetics 41 (6), 454-458, 2004 | 334 | 2004 |
| 5, 10‐Methylenetetrahydrofolate reductase 677C→ T and 1298A→ C mutations are genetic determinants of elevated homocysteine R Castro, I Rivera, P Ravasco, C Jakobs, HJ Blom, ME Camilo, ... Qjm 96 (4), 297-303, 2003 | 150 | 2003 |
| Intracellular S-adenosylhomocysteine increased levels are associated with DNA hypomethylation in HUVEC R Castro, I Rivera, C Martins, EA Struys, EEW Jansen, N Clode, LM Graça, ... Journal of molecular medicine 83, 831-836, 2005 | 122 | 2005 |
| S-adenosylhomocysteine induces inflammation through NFkB: A possible role for EZH2 in endothelial cell activation M Barroso, D Kao, HJ Blom, IT de Almeida, R Castro, J Loscalzo, ... Biochimica et biophysica acta (BBA)-Molecular Basis of Disease 1862 (1), 82-92, 2016 | 80 | 2016 |
| The link between hyperhomocysteinemia and hypomethylation: Implications for cardiovascular disease M Barroso, DE Handy, R Castro Journal of Inborn Errors of Metabolism and Screening 5, e160024, 2019 | 73 | 2019 |
| Inhibition of cellular methyltransferases promotes endothelial cell activation by suppressing glutathione peroxidase 1 protein expression M Barroso, C Florindo, H Kalwa, Z Silva, AA Turanov, BA Carlson, ... Journal of Biological Chemistry 289 (22), 15350-15362, 2014 | 58 | 2014 |
| Serum homocysteine: interplay with other circulating and genetic factors in association to Alzheimer's type dementia JF Cascalheira, SS João, SS Pinhanços, R Castro, M Palmeira, ... Clinical biochemistry 42 (9), 783-790, 2009 | 50 | 2009 |
| The TCN2 776C> G polymorphism correlates with vitamin B12 cellular delivery in healthy adult populations R Castro, M Barroso, M Rocha, R Esse, R Ramos, P Ravasco, I Rivera, ... Clinical biochemistry 43 (7-8), 645-649, 2010 | 43 | 2010 |
| Protein arginine hypomethylation in a mouse model of cystathionine β-synthase deficiency R Esse, A Imbard, C Florindo, S Gupta, EP Quinlivan, M Davids, ... The FASEB Journal 28 (6), 2686, 2014 | 42 | 2014 |
| Global protein and histone arginine methylation are affected in a tissue-specific manner in a rat model of diet-induced hyperhomocysteinemia R Esse, C Florindo, A Imbard, MS Rocha, AS De Vriese, YM Smulders, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1832 (10 …, 2013 | 42 | 2013 |
| Endothelial aquaporins and hypomethylation: Potential implications for atherosclerosis and cardiovascular disease IV Da Silva, M Barroso, T Moura, R Castro, G Soveral International journal of molecular sciences 19 (1), 130, 2018 | 33 | 2018 |
| Protein arginine methylation is more prone to inhibition by S-adenosylhomocysteine than DNA methylation in vascular endothelial cells R Esse, MS Rocha, M Barroso, C Florindo, T Teerlink, RM Kok, ... PLoS One 8 (2), e55483, 2013 | 33 | 2013 |
| Sialyl Lewisx-dependent binding of human monocyte-derived dendritic cells to selectins Z Silva, ZQ Tong, MG Cabral, C Martins, R Castro, C Reis, H Trindade, ... Biochemical and biophysical research communications 409 (3), 459-464, 2011 | 32 | 2011 |
| Homocysteine metabolism in children and adolescents: influence of age on plasma biomarkers and correspondent genotype interactions H Caldeira-Araújo, R Ramos, C Florindo, I Rivera, R Castro, ... Nutrients 11 (3), 646, 2019 | 28 | 2019 |
| Quantification of plasma S-adenosylmethionine and S-adenosylhomocysteine as their fluorescent 1, N6-etheno derivatives: an adaptation of previously described methodology R Castro, EA Struys, EEW Jansen, HJ Blom, IT de Almeida, C Jakobs Journal of pharmaceutical and biomedical analysis 29 (5), 963-968, 2002 | 28 | 2002 |
| Cellular hypomethylation is associated with impaired nitric oxide production by cultured human endothelial cells M Barroso, MS Rocha, R Esse, I Gonçalves, AQ Gomes, T Teerlink, ... Amino Acids 42, 1903-1911, 2012 | 26 | 2012 |
