| Probabilistic cell-type assignment of single-cell RNA-seq for tumor microenvironment profiling AW Zhang, C O’Flanagan, EA Chavez, JLP Lim, N Ceglia, A McPherson, ... Nature methods 16 (10), 1007-1015, 2019 | 322 | 2019 |
| When less may be more: calorie restriction and response to cancer therapy CH O'Flanagan, LA Smith, SB McDonell, SD Hursting BMC Medicine 15 (106), 2017 | 251 | 2017 |
| Dissociation of solid tumour tissues with cold active protease for single-cell RNA-seq minimizes conserved collagenase associated stress responses CH O'Flanagan, KR Campbell, AW Zhang, F Kabeer, JLP Lim, J Biele, ... Genome Biology 20, 2019 | 244 | 2019 |
| Clonal decomposition and DNA replication states defined by scaled single-cell genome sequencing E Laks, A McPherson, H Zahn, D Lai, A Steif, J Brimhall, J Biele, B Wang, ... Cell 179 (5), 1207-1221. e22, 2019 | 228 | 2019 |
| The role of the insulin/IGF system in cancer: lessons learned from clinical trials and the energy balance-cancer link LW Bowers, EL Rossi, CH O’Flanagan, LA deGraffenried, SD Hursting Frontiers in endocrinology 6, 77, 2015 | 176 | 2015 |
| Clonal fitness inferred from time-series modelling of single-cell cancer genomes S Salehi, F Kabeer, N Ceglia, M Andronescu, MJ Williams, KR Campbell, ... Nature 595 (7868), 585-590, 2021 | 120 | 2021 |
| Insulin-like Growth Factor-1 Signaling is essential for Mitochondrial Biogenesis and Mitophagy in Cancer Cells A Lyons, M Coleman, S Riis, C Favre, CH O'Flanagan, AV Zhdanov, ... Journal of Biological Chemistry, 2017 | 110 | 2017 |
| clonealign: statistical integration of independent single-cell RNA and DNA sequencing data from human cancers KR Campbell, A Steif, E Laks, H Zahn, D Lai, A McPherson, H Farahani, ... Genome biology 20, 1-12, 2019 | 108 | 2019 |
| Single-cell genomic variation induced by mutational processes in cancer T Funnell, CH O’Flanagan, MJ Williams, A McPherson, S McKinney, ... Nature 612 (7938), 106-115, 2022 | 98* | 2022 |
| A unique morphological phenotype in chemoresistant triple negative breast cancer reveals metabolic reprogramming and PLIN4 expression as a molecular vulnerability I Sirois, A Aguilar-Mahecha, J Lafleur, E Fowler, V Vu, M Scriver, ... Molecular Cancer Research, 2019 | 87 | 2019 |
| The Parkinson’s gene PINK1 regulates cell cycle progression and promotes cancer-associated phenotypes CH O'flanagan, VA Morais, W Wurst, B De Strooper, C O'neill Oncogene 34 (11), 1363-1374, 2015 | 85 | 2015 |
| PINK1 signalling in cancer biology CH O'Flanagan, C O'Neill Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1846 (2), 590-598, 2014 | 78 | 2014 |
| Obesity and cancer metabolism: a perspective on interacting tumor–intrinsic and extrinsic factors SS Doerstling, CH O’Flanagan, SD Hursting Frontiers in oncology 7, 216, 2017 | 73 | 2017 |
| A weighty problem: metabolic perturbations and the obesity-cancer link CH O’Flanagan, LW Bowers, SD Hursting Hormone molecular biology and clinical investigation 23 (2), 47-57, 2015 | 68 | 2015 |
| Starving cancer from the outside and inside: separate and combined effects of calorie restriction and autophagy inhibition on Ras-driven tumors LM Lashinger, CH O’Flanagan, SM Dunlap, AJ Rasmussen, S Sweeney, ... Cancer & metabolism 4, 1-11, 2016 | 52 | 2016 |
| Metabolic reprogramming underlies metastatic potential in an obesity-responsive murine model of metastatic triple negative breast cancer CH O’Flanagan, EL Rossi, SB McDonell, X Chen, YH Tsai, JS Parker, ... NPJ breast cancer 3 (1), 26, 2017 | 46 | 2017 |
| Metabolic reprogramming by folate restriction leads to a less aggressive cancer phenotype Z Ashkavand, C O'Flanagan, M Hennig, X Du, SD Hursting, SA Krupenko Molecular cancer research 15 (2), 189-200, 2017 | 43 | 2017 |
| Translating mechanism-based strategies to break the obesity− cancer link: a narrative review LA Smith, CH O’Flanagan, LW Bowers, EH Allott, SD Hursting Journal of the Academy of Nutrition and Dietetics 118 (4), 652-667, 2018 | 41 | 2018 |
| IGF-1R inhibition sensitizes breast cancer cells to ATM-related kinase (ATR) inhibitor and cisplatin CH O'Flanagan, S O'shea, A Lyons, FM Fogarty, N McCabe, RD Kennedy, ... Oncotarget 7 (35), 56826, 2016 | 31 | 2016 |
| FES-related tyrosine kinase activates the insulin-like growth factor-1 receptor at sites of cell adhesion J Stanika, L Rieger, S O'Shea, O Cox, M Coleman, C O'Flanagan, ... Oncogene 37, 3131–3150, 2018 | 25 | 2018 |