| Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans NR Gavva, JJS Treanor, A Garami, L Fang, S Surapaneni, A Akrami, ... Pain 136 (1), 202-210, 2008 | 586 | 2008 |
| Physicochemical properties of pharmaceutical co-crystals: a case study of ten AMG 517 co-crystals MK Stanton, A Bak Crystal Growth and Design 8 (10), 3856-3862, 2008 | 285 | 2008 |
| The co‐crystal approach to improve the exposure of a water‐insoluble compound: AMG 517 sorbic acid co‐crystal characterization and pharmacokinetics A Bak, A Gore, E Yanez, M Stanton, S Tufekcic, R Syed, A Akrami, M Rose, ... Journal of pharmaceutical sciences 97 (9), 3942-3956, 2008 | 271 | 2008 |
| Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade NR Gavva, AW Bannon, DN Hovland Jr, SG Lehto, L Klionsky, ... The Journal of pharmacology and experimental therapeutics 323 (1), 128-137, 2007 | 209 | 2007 |
| Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes T Biftu, R Sinha-Roy, P Chen, X Qian, D Feng, JT Kuethe, G Scapin, ... Journal of Medicinal Chemistry 57 (8), 3205-3212, 2014 | 197 | 2014 |
| Preclinical evaluation of AMG 900, a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines M Payton, TL Bush, G Chung, B Ziegler, P Eden, P McElroy, S Ross, ... Cancer research 70 (23), 9846-9854, 2010 | 146 | 2010 |
| Endosomal escape of delivered mRNA from endosomal recycling tubules visualized at the nanoscale P Paramasivam, C Franke, M Stöter, A Höijer, S Bartesaghi, A Sabirsh, ... Journal of Cell Biology 221 (2), e202110137, 2021 | 140 | 2021 |
| Discovery of a Potent, Selective, and Orally Bioavailable c-Met Inhibitor: 1-(2-Hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl … L Liu, A Siegmund, N Xi, P Kaplan-Lefko, K Rex, A Chen, J Lin, ... Journal of medicinal chemistry 51 (13), 3688-3691, 2008 | 121 | 2008 |
| Local delivery of macromolecules to treat diseases associated with the colon A Bak, M Ashford, DJ Brayden Advanced drug delivery reviews 136, 2-27, 2018 | 106 | 2018 |
| Physicochemical and formulation developability assessment for therapeutic peptide delivery—a primer A Bak, D Leung, SE Barrett, S Forster, EC Minnihan, AW Leithead, ... The AAPS journal 17, 144-155, 2015 | 99 | 2015 |
| Drug substance and former structure property relationships in 15 diverse pharmaceutical co-crystals MK Stanton, S Tufekcic, C Morgan, A Bak Crystal Growth and Design 9 (3), 1344-1352, 2009 | 95 | 2009 |
| Recent advances in polymeric materials for the delivery of RNA therapeutics D Ulkoski, A Bak, JT Wilson, VR Krishnamurthy Expert Opinion on Drug Delivery 16 (11), 1149-1167, 2019 | 72 | 2019 |
| Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase VJ Cee, AC Cheng, K Romero, S Bellon, C Mohr, DA Whittington, A Bak, ... Bioorganic & medicinal chemistry letters 19 (2), 424-427, 2009 | 65 | 2009 |
| Acyloxyalkoxy-based cyclic prodrugs of opioid peptides: evaluation of the chemical and enzymatic stability as well as their transport properties across Caco-2 cell monolayers A Bak, OS Gudmundsson, GJ Friis, TJ Siahaan, RT Borchardt Pharmaceutical research 16 (1), 24-29, 1999 | 61 | 1999 |
| A new and improved method for the preparation of drug nanosuspension formulations using acoustic mixing technology DH Leung, DJ Lamberto, L Liu, E Kwong, T Nelson, T Rhodes, A Bak International Journal of Pharmaceutics 473 (1-2), 10-19, 2014 | 55 | 2014 |
| N-terminal 4-imidazolidinone prodrugs of Leu-enkephalin: synthesis, chemical and enzymatic stability studies A Bak, M Fich, BD Larsen, S Frokjaer, GJ Friis European journal of pharmaceutical sciences 7 (4), 317-323, 1999 | 54 | 1999 |
| Discovery of a potent, selective, and orally bioavailable pyridinyl-pyrimidine phthalazine Aurora kinase inhibitor VJ Cee, LB Schenkel, BL Hodous, HL Deak, HN Nguyen, PR Olivieri, ... Journal of medicinal chemistry 53 (17), 6368-6377, 2010 | 51 | 2010 |
| Two novel pharmaceutical cocrystals of a development compound–screening, scale-up, and characterization DH Leung, S Lohani, RG Ball, N Canfield, Y Wang, T Rhodes, A Bak Crystal growth & design 12 (3), 1254-1262, 2012 | 50 | 2012 |
| Discovery of N-(4-(3-(2-Aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine (AMG 900), A Highly Selective, Orally … S Geuns-Meyer, VJ Cee, HL Deak, B Du, BL Hodous, HN Nguyen, ... Journal of Medicinal Chemistry 58 (13), 5189-5207, 2015 | 44 | 2015 |
| Development of a Convenient In Vitro Gel Diffusion Model for Predicting the In Vivo Performance of Subcutaneous Parenteral Formulations of Large and Small … DH Leung, Y Kapoor, C Alleyne, E Walsh, A Leithead, B Habulihaz, ... AAPS PharmSciTech 18, 2203-2213, 2017 | 42 | 2017 |
