| Nitroreductase gene-directed enzyme prodrug therapy: insights and advances toward clinical utility EM Williams, RF Little, AM Mowday, MH Rich, JVE Chan-Hyams, ... Biochemical Journal 471 (2), 131-153, 2015 | 176 | 2015 |
| Mechanistic understanding enables the rational design of salicylanilide combination therapies for Gram-negative infections JN Copp, D Pletzer, AS Brown, JV der Heijden, CM Miton, RJ Edgar, ... mBio 11 (5), e02068-20, 2020 | 38 | 2020 |
| Toward a high-throughput screening platform for directed evolution of enzymes that activate genotoxic prodrugs JN Copp, EM Williams, MH Rich, AV Patterson, JB Smaill, DF Ackerley Protein Engineering, Design & Selection 27 (10), 399-403, 2014 | 34 | 2014 |
| Mechanism of two-/four-electron reduction of nitroaromatics by oxygen-insensitive nitroreductases: the role of a non-enzymatic reduction step B Valiauga, L Misevičienė, MH Rich, DF Ackerley, J Šarlauskas, N Čėnas Molecules 23 (7), 1672, 2018 | 23 | 2018 |
| Engineering the Escherichia coli Nitroreductase NfsA to Create a Flexible Enzyme-Prodrug Activation System AV Sharrock, SP McManaway, MH Rich, JS Mumm, IF Hermans, M Tercel, ... Frontiers in Pharmacology 12, 701456, 2021 | 16 | 2021 |
| Engineering Escherichia coli NfsB to activate a hypoxia-resistant analogue of the PET probe EF5 to enable non-invasive imaging during enzyme prodrug therapy EM Williams, MH Rich, AM Mowday, A Ashoorzadeh, JN Copp, CP Guise, ... Biochemistry 58 (35), 3700-3710, 2019 | 14 | 2019 |
| Evaluation of NfsA-like nitroreductases from Neisseria meningitidis and Bartonella henselae for enzyme-prodrug therapy, targeted cellular ablation, and … MH Rich, AV Sharrock, KR Hall, DF Ackerley, JK MacKichan Biotechnology letters 40, 359-367, 2018 | 13 | 2018 |
| Intracellular complexities of acquiring a new enzymatic function revealed by mass-randomisation of active site residues KR Hall, KJ Robins, EM Williams, MH Rich, MJ Calcott, JN Copp, RF Little, ... Elife 9, e59081, 2020 | 9* | 2020 |
| A metagenomic library cloning strategy that promotes high-level expression of captured genes to enable efficient functional screening MH Rich, AV Sharrock, TS Mulligan, F Matthews, AS Brown, ... Cell Chemical Biology 30 (12), 1680-1691. e6, 2023 | 3 | 2023 |
| Non-canonical (unusual) amino acids as a toolbox for antimicrobial and anticancer peptide synthesis MH Rich, KE O'Connor, T Narancic Amino Acids, Peptides and Proteins, 44-63, 2020 | 3 | 2020 |
| Discovery and directed evolution of nitroreductase enzymes for activation of prodrugs and PET imaging compounds MH Rich Open Access Te Herenga Waka-Victoria University of Wellington, 2017 | 3 | 2017 |
| Directed evolution of the B. subtilis nitroreductase YfkO improves activation of the PET-capable probe SN33623 and CB1954 prodrug MH Rich, AV Sharrock, A Ashoorzadeh, AV Patterson, JB Smaill, ... Biotechnology Letters 43 (1), 203-211, 2021 | 2 | 2021 |
| Upcycling atmospheric CO 2 to polyhydroxyalkanoates via sequential chemo-biocatalytic processes M Bruch, JE Sanchez-Velandia, J Rodríguez-Pereira, M Rich, N Pearcy, ... Green Chemistry, 2024 | 1 | 2024 |
Elsie WilliamsVictoria University of Wellington確認したメール アドレス: vuw.ac.nz