The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron–sulfur cluster biogenesis C Pondarré, BB Antiochos, DR Campagna, SL Clarke, EL Greer, KM Deck, ... Human molecular genetics 15 (6), 953-964, 2006 | 257 | 2006 |
Ferrochelatase at the millennium: structures, mechanisms and [2Fe-2S] clusters HA Dailey*, TA Dailey, CK Wu**, AE Medlock, JP Rose, KF Wang Cellular and Molecular Life Sciences CMLS 57, 1909-1926, 2000 | 212 | 2000 |
A novel role for progesterone receptor membrane component 1 (PGRMC1): a partner and regulator of ferrochelatase RB Piel III, MT Shiferaw, AA Vashisht, JR Marcero, JL Praissman, ... Biochemistry 55 (37), 5204-5217, 2016 | 123 | 2016 |
From synthesis to utilization: The ins and outs of mitochondrial heme SA Swenson, CM Moore, JR Marcero, AE Medlock, AR Reddi, ... Cells 9 (3), 579, 2020 | 121 | 2020 |
Identification of the mitochondrial heme metabolism complex AE Medlock, MT Shiferaw, JR Marcero, AA Vashisht, JA Wohlschlegel, ... PloS one 10 (8), e0135896, 2015 | 120 | 2015 |
Substrate interactions with human ferrochelatase A Medlock, L Swartz, TA Dailey, HA Dailey, WN Lanzilotta Proceedings of the National Academy of Sciences 104 (6), 1789-1793, 2007 | 107 | 2007 |
Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts DI Shah, N Takahashi-Makise, JD Cooney, L Li, IJ Schultz, EL Pierce, ... Nature 491 (7425), 608-612, 2012 | 103 | 2012 |
Human coproporphyrinogen oxidase is not a metalloprotein AE Medlock, HA Dailey Journal of Biological Chemistry 271 (51), 32507-32510, 1996 | 85 | 1996 |
Glutamine via α-ketoglutarate dehydrogenase provides succinyl-CoA for heme synthesis during erythropoiesis JS Burch, JR Marcero, JA Maschek, JE Cox, LK Jackson, AE Medlock, ... Blood, The Journal of the American Society of Hematology 132 (10), 987-998, 2018 | 84 | 2018 |
A π-helix switch selective for porphyrin deprotonation and product release in human ferrochelatase AE Medlock, TA Dailey, TA Ross, HA Dailey, WN Lanzilotta Journal of molecular biology 373 (4), 1006-1016, 2007 | 75 | 2007 |
Product release rather than chelation determines metal specificity for ferrochelatase AE Medlock, M Carter, TA Dailey, HA Dailey, WN Lanzilotta Journal of molecular biology 393 (2), 308-319, 2009 | 67 | 2009 |
Thoughts on interactions between PGRMC1 and diverse attested and potential hydrophobic ligands MA Cahill, AE Medlock The Journal of steroid biochemistry and molecular biology 171, 11-33, 2017 | 61 | 2017 |
The mitochondrial heme metabolon: Insights into the complex (ity) of heme synthesis and distribution RB Piel III, HA Dailey Jr, AE Medlock Molecular genetics and metabolism 128 (3), 198-203, 2019 | 57 | 2019 |
Resonance Raman spectra of ferrochelatase reveal porphyrin distortion upon metal binding ME Blackwood, TS Rush, A Medlock, HA Dailey, TG Spiro Journal of the American Chemical Society 119 (50), 12170-12174, 1997 | 51 | 1997 |
Mitochondrial–nuclear heme trafficking in budding yeast is regulated by GTPases that control mitochondrial dynamics and ER contact sites O Martinez-Guzman, MM Willoughby, A Saini, JV Dietz, I Bohovych, ... Journal of cell science 133 (10), jcs237917, 2020 | 44 | 2020 |
Examination of the activity of carboxyl-terminal chimeric constructs of human and yeast ferrochelatases AE Medlock, HA Dailey Biochemistry 39 (25), 7461-7467, 2000 | 42 | 2000 |
Altered orientation of active site residues in variants of human ferrochelatase. Evidence for a hydrogen bond network involved in catalysis HA Dailey, CK Wu, P Horanyi, AE Medlock, W Najahi-Missaoui, ... Biochemistry 46 (27), 7973-7979, 2007 | 35 | 2007 |
Ferrochelatase: mapping the intersection of iron and porphyrin metabolism in the mitochondria CD Obi, T Bhuiyan, HA Dailey, AE Medlock Frontiers in Cell and Developmental Biology 10, 894591, 2022 | 25 | 2022 |
A primer on heme biosynthesis HA Dailey, AE Medlock Biological Chemistry 403 (11-12), 985-1003, 2022 | 23 | 2022 |
Mitochondrial contact site and cristae organizing system (MICOS) machinery supports heme biosynthesis by enabling optimal performance of ferrochelatase JV Dietz, MM Willoughby, RB Piel III, TA Ross, I Bohovych, HG Addis, ... Redox biology 46, 102125, 2021 | 23 | 2021 |