| Discovery of novel N-substituted thiazolidinediones (TZDs) as HDAC8 inhibitors: in-silico studies, synthesis, and biological evaluation N Upadhyay, K Tilekar, N Jänsch, M Schweipert, JD Hess, LH Macias, ... Bioorganic chemistry 100, 103934, 2020 | 45 | 2020 |
| Discovery of 5-naphthylidene-2, 4-thiazolidinedione derivatives as selective HDAC8 inhibitors and evaluation of their cytotoxic effects in leukemic cell lines K Tilekar, N Upadhyay, N Jänsch, M Schweipert, P Mrowka, ... Bioorganic Chemistry 95, 103522, 2020 | 45 | 2020 |
| The enzyme activity of histone deacetylase 8 is modulated by a redox-switch N Jänsch, C Meyners, M Muth, A Kopranovic, O Witt, I Oehme, ... Redox Biology 20, 60-67, 2019 | 40 | 2019 |
| Synthesis and structure activity relationship of 1, 3-benzo-thiazine-2-thiones as selective HDAC8 inhibitors B Wolff, N Jänsch, WO Sugiarto, S Frühschulz, M Lang, R Altintas, ... European journal of medicinal chemistry 184, 111756, 2019 | 30 | 2019 |
| Assessment of tractable cysteines for covalent targeting by screening covalent fragments L Petri, P Ábrányi‐Balogh, I Tímea, G Pálfy, A Perczel, D Knez, M Hrast, ... ChemBioChem 22 (4), 743-753, 2021 | 19 | 2021 |
| Covalent inhibition of histone deacetylase 8 by 3, 4-dihydro-2H-pyrimido [1, 2-c][1, 3] benzothiazin-6-imine M Muth, N Jänsch, A Kopranovic, A Krämer, N Wössner, M Jung, ... Biochimica et Biophysica Acta (BBA)-General Subjects 1863 (3), 577-585, 2019 | 18 | 2019 |
| Kinetically selective and potent inhibitors of HDAC8 M Schweipert, N Jänsch, WO Sugiarto, FJ Meyer-Almes Biological Chemistry 400 (6), 733-743, 2019 | 11 | 2019 |
| Mechanistic insights into binding of ligands with thiazolidinedione warhead to human histone deacetylase 4 M Schweipert, N Jänsch, N Upadhyay, K Tilekar, E Wozny, S Basheer, ... Pharmaceuticals 14 (10), 1032, 2021 | 9 | 2021 |
| Methionine 274 is not the determining factor for selective inhibition of histone deacetylase 8 (HDAC8) by L-shaped inhibitors N Jänsch, KL Lang, FJ Meyer-Almes International Journal of Molecular Sciences 23 (19), 11775, 2022 | 8 | 2022 |
| Switching the switch: ligand induced disulfide formation in HDAC8 N Jänsch, WO Sugiarto, M Muth, A Kopranovic, C Desczyk, M Ballweg, ... Chemistry–A European Journal 26 (58), 13249-13255, 2020 | 8 | 2020 |
| 3‐Chloro‐5‐Substituted‐1, 2, 4‐Thiadiazoles (TDZs) as Selective and Efficient Protein Thiol Modifiers N Jänsch, A Frühauf, M Schweipert, C Debarnot, M Erhardt, ... ChemBioChem 23 (21), e202200417, 2022 | 4 | 2022 |
| Using design of experiment to optimize enzyme activity assays N Jänsch, F Colin, M Schröder, FJ Meyer-Almes ChemTexts 5 (4), 20, 2019 | 3 | 2019 |
| Entwicklung neuer Strategien zur spezifischen Hemmung humaner Histondeacetylase 8 N Jänsch Technische Universität Darmstadt, 2023 | | 2023 |
