| Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy CC Liu, T Kanekiyo, H Xu, G Bu Nature Reviews Neurology 9 (2), 106-118, 2013 | 3966 | 2013 |
| Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies Y Yamazaki, N Zhao, TR Caulfield, CC Liu, G Bu Nature Reviews Neurology 15 (9), 501-518, 2019 | 1157 | 2019 |
| Apolipoprotein E is a ligand for triggering receptor expressed on myeloid cells 2 (TREM2) Y Atagi, CC Liu, MM Painter, XF Chen, C Verbeeck, H Zheng, X Li, ... Journal of Biological Chemistry 290 (43), 26043-26050, 2015 | 539 | 2015 |
| Apolipoprotein E, receptors, and modulation of Alzheimer’s disease N Zhao, CC Liu, W Qiao, G Bu Biological psychiatry 83 (4), 347-357, 2018 | 390 | 2018 |
| ApoE4 accelerates early seeding of amyloid pathology CC Liu, N Zhao, Y Fu, N Wang, C Linares, CW Tsai, G Bu Neuron 96 (5), 1024-1032. e3, 2017 | 386 | 2017 |
| ApoE in Alzheimer’s disease: pathophysiology and therapeutic strategies AC Raulin, SV Doss, ZA Trottier, TC Ikezu, G Bu, CC Liu Molecular neurodegeneration 17 (1), 72, 2022 | 350 | 2022 |
| Soluble TREM2 induces inflammatory responses and enhances microglial survival L Zhong, XF Chen, T Wang, Z Wang, C Liao, Z Wang, R Huang, D Wang, ... Journal of Experimental Medicine 214 (3), 597-607, 2017 | 329 | 2017 |
| TREM2 promotes microglial survival by activating Wnt/β-catenin pathway H Zheng, L Jia, CC Liu, Z Rong, L Zhong, L Yang, XF Chen, JD Fryer, ... Journal of Neuroscience 37 (7), 1772-1784, 2017 | 323 | 2017 |
| Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model L Zhong, Y Xu, R Zhuo, T Wang, K Wang, R Huang, D Wang, Y Gao, ... Nature communications 10 (1), 1365, 2019 | 307 | 2019 |
| Neuronal clearance of amyloid-β by endocytic receptor LRP1 T Kanekiyo, JR Cirrito, CC Liu, M Shinohara, J Li, DR Schuler, ... Journal of Neuroscience 33 (49), 19276-19283, 2013 | 306 | 2013 |
| Apolipoprotein E4 impairs neuronal insulin signaling by trapping insulin receptor in the endosomes N Zhao, CC Liu, AJ Van Ingelgom, YA Martens, C Linares, JA Knight, ... Neuron 96 (1), 115-129. e5, 2017 | 288 | 2017 |
| APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids J Zhao, Y Fu, Y Yamazaki, Y Ren, MD Davis, CC Liu, W Lu, X Wang, ... Nature communications 11 (1), 5540, 2020 | 273 | 2020 |
| LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β T Kanekiyo, CC Liu, M Shinohara, J Li, G Bu Journal of Neuroscience 32 (46), 16458-16465, 2012 | 251 | 2012 |
| Astrocytic LRP1 mediates brain Aβ clearance and impacts amyloid deposition CC Liu, J Hu, N Zhao, J Wang, N Wang, JR Cirrito, T Kanekiyo, ... Journal of Neuroscience 37 (15), 4023-4031, 2017 | 246 | 2017 |
| LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy CC Liu, J Prior, D Piwnica-Worms, G Bu Proceedings of the National Academy of Sciences 107 (11), 5136-5141, 2010 | 244 | 2010 |
| Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-β uptake T Kanekiyo, J Zhang, Q Liu, CC Liu, L Zhang, G Bu Journal of Neuroscience 31 (5), 1644-1651, 2011 | 242 | 2011 |
| Vascular cell senescence contributes to blood–brain barrier breakdown Y Yamazaki, DJ Baker, M Tachibana, CC Liu, JM Van Deursen, TG Brott, ... Stroke 47 (4), 1068-1077, 2016 | 237 | 2016 |
| ApoE Cascade Hypothesis in the pathogenesis of Alzheimer’s disease and related dementias YA Martens, N Zhao, CC Liu, T Kanekiyo, AJ Yang, AM Goate, ... Neuron 110 (8), 1304-1317, 2022 | 214 | 2022 |
| Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer’s disease CC Liu, CW Tsai, F Deak, J Rogers, M Penuliar, YM Sung, JN Maher, ... Neuron 84 (1), 63-77, 2014 | 213 | 2014 |
| Alzheimer’s risk factors age, APOE genotype, and sex drive distinct molecular pathways N Zhao, Y Ren, Y Yamazaki, W Qiao, F Li, LM Felton, ... Neuron 106 (5), 727-742. e6, 2020 | 207 | 2020 |