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| Mapping the human DC lineage through the integration of high-dimensional techniques P See, CA Dutertre, J Chen, P Günther, N McGovern, SE Irac, M Gunawan, ... Science 356 (6342), eaag3009, 2017 | 444 | 2017 |
| Efficient endoderm induction from human pluripotent stem cells by logically directing signals controlling lineage bifurcations KM Loh, LT Ang, J Zhang, V Kumar, J Ang, JQ Auyeong, KL Lee, ... Cell stem cell 14 (2), 237-252, 2014 | 436 | 2014 |
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| Generation of human PSC-derived kidney organoids with patterned nephron segments and a de novo vascular network JH Low, P Li, EGY Chew, B Zhou, K Suzuki, T Zhang, MM Lian, M Liu, ... Cell stem cell 25 (3), 373-387. e9, 2019 | 309 | 2019 |
| Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice Q Chen, M Khoury, J Chen Proceedings of the National Academy of Sciences 106 (51), 21783-21788, 2009 | 304 | 2009 |
| A roadmap for human liver differentiation from pluripotent stem cells LT Ang, AKY Tan, MI Autio, SH Goh, SH Choo, KL Lee, J Tan, B Pan, ... Cell reports 22 (8), 2190-2205, 2018 | 195 | 2018 |
| Development of a new patient-derived xenograft humanised mouse model to study human-specific tumour microenvironment and immunotherapy Y Zhao, TWH Shuen, TB Toh, XY Chan, M Liu, SY Tan, Y Fan, H Yang, ... Gut 67 (10), 1845-1854, 2018 | 192 | 2018 |
| CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses SZ Chong, M Evrard, S Devi, J Chen, JY Lim, P See, Y Zhang, JM Adrover, ... Journal of Experimental Medicine 213 (11), 2293-2314, 2016 | 147 | 2016 |
| Addressing drug resistance in cancer with macromolecular chemotherapeutic agents NH Park, W Cheng, F Lai, C Yang, P Florez de Sessions, B Periaswamy, ... Journal of the American Chemical Society 140 (12), 4244-4252, 2018 | 138 | 2018 |
| Opposing activities of the R as and H ippo pathways converge on regulation of YAP protein turnover X Hong, HT Nguyen, Q Chen, R Zhang, Z Hagman, PM Voorhoeve, ... The EMBO journal 33 (21), 2447-2457, 2014 | 138 | 2014 |
| Targeted elimination of mutant mitochondrial DNA in MELAS-iPSCs by mitoTALENs Y Yang, H Wu, X Kang, Y Liang, T Lan, T Li, T Tan, J Peng, Q Zhang, G An, ... Protein & cell 9 (3), 283-297, 2018 | 129 | 2018 |
| GM-CSF and IL-4 stimulate antibody responses in humanized mice by promoting T, B, and dendritic cell maturation Q Chen, F He, J Kwang, JKY Chan, J Chen The Journal of Immunology 189 (11), 5223-5229, 2012 | 127 | 2012 |
| Engineering humanized mice for improved hematopoietic reconstitution AC Drake, Q Chen, J Chen Cellular & molecular immunology 9 (3), 215-224, 2012 | 112 | 2012 |
| Humanized mice as unique tools for human-specific studies KSM Yong, Z Her, Q Chen Archivum immunologiae et therapiae experimentalis 66, 245-266, 2018 | 110 | 2018 |
| Inhibition of megakaryocyte development in the bone marrow underlies dengue virus-induced thrombocytopenia in humanized mice A Sridharan, Q Chen, KF Tang, EE Ooi, ML Hibberd, J Chen Journal of virology 87 (21), 11648-11658, 2013 | 105 | 2013 |
| Human natural killer cells control Plasmodium falciparum infection by eliminating infected red blood cells Q Chen, A Amaladoss, W Ye, M Liu, S Dummler, F Kong, LH Wong, ... Proceedings of the National Academy of Sciences 111 (4), 1479-1484, 2014 | 97 | 2014 |
| Hypoxia induces HIF1α-dependent epigenetic vulnerability in triple negative breast cancer to confer immune effector dysfunction and resistance to anti-PD-1 immunotherapy S Ma, Y Zhao, WC Lee, LT Ong, PL Lee, Z Jiang, G Oguz, Z Niu, M Liu, ... Nature communications 13 (1), 4118, 2022 | 95 | 2022 |
| CD4+ T Cells Mediate the Development of Liver Fibrosis in High Fat Diet-Induced NAFLD in Humanized Mice Z Her, JHL Tan, YS Lim, SY Tan, XY Chan, WWS Tan, M Liu, KSM Yong, ... Frontiers in immunology 11, 580968, 2020 | 84 | 2020 |
| Mesenchymal stem cells secreting angiopoietin-like-5 support efficient expansion of human hematopoietic stem cells without compromising their repopulating potential M Khoury, A Drake, Q Chen, D Dong, I Leskov, MF Fragoso, Y Li, ... Stem cells and development 20 (8), 1371-1381, 2011 | 83 | 2011 |