フォロー
Michael J. Eck
Michael J. Eck
Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
確認したメール アドレス: dfci.harvard.edu
タイトル
引用先
引用先
EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
JG Paez, PA Janne, JC Lee, S Tracy, H Greulich, S Gabriel, P Herman, ...
Science 304 (5676), 1497-1500, 2004
121882004
EGFR Mutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib
S Kobayashi, TJ Boggon, T Dayaram, PA Jänne, O Kocher, M Meyerson, ...
New England Journal of Medicine 352 (8), 786-792, 2005
48802005
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
RL Levine, M Wadleigh, J Cools, BL Ebert, G Wernig, BJP Huntly, ...
Cancer cell 7 (4), 387-397, 2005
39252005
The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
CH Yun, KE Mengwasser, AV Toms, MS Woo, H Greulich, KK Wong, ...
Proceedings of the National Academy of Sciences 105 (6), 2070-2075, 2008
23572008
Three-dimensional structure of the tyrosine kinase c-Src
W Xu, SC Harrison, MJ Eck
Nature 385 (6617), 595-602, 1997
18971997
Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity
CH Yun, TJ Boggon, Y Li, MS Woo, H Greulich, M Meyerson, MJ Eck
Cancer cell 11 (3), 217-227, 2007
12892007
Novel mutant-selective EGFR kinase inhibitors against EGFR T790M
W Zhou, D Ercan, L Chen, CH Yun, D Li, M Capelletti, AB Cortot, ...
Nature 462 (7276), 1070-1074, 2009
12112009
Catalytic specificity of protein-tyrosine kinases is critical for selective signalling
Z Songyang, KL Carraway III, MJ Eck, SC Harrison, RA Feldman, ...
Nature 373 (6514), 536-539, 1995
11721995
Crystal structure of the tyrosine phosphatase SHP-2
P Hof, S Pluskey, S Dhe-Paganon, MJ Eck, SE Shoelson
Cell 92 (4), 441-450, 1998
11591998
Crystal structures of c-Src reveal features of its autoinhibitory mechanism
W Xu, A Doshi, M Lei, MJ Eck, SC Harrison
Molecular cell 3 (5), 629-638, 1999
11341999
Mechanism and function of formins in the control of actin assembly
BL Goode, MJ Eck
Annu. Rev. Biochem. 76 (1), 593-627, 2007
10812007
Structure and regulation of Src family kinases
TJ Boggon, MJ Eck
Oncogene 23 (48), 7918-7927, 2004
9422004
The structure of tumor necrosis factor-α at 2.6 Å resolution: Implications for receptor binding
MJ Eck, SR Sprang
Journal of Biological Chemistry 264 (29), 17595-17605, 1989
9391989
Overcoming EGFR (T790M) and EGFR (C797S) resistance with mutant-selective allosteric inhibitors
Y Jia, CH Yun, E Park, D Ercan, M Manuia, J Juarez, C Xu, K Rhee, ...
Nature 534 (7605), 129-132, 2016
8632016
Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch
M Lei, W Lu, W Meng, MC Parrini, MJ Eck, BJ Mayer, SC Harrison
Cell 102 (3), 387-397, 2000
6862000
Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck
MJ Eck, SE Shoelson, SC Harrison
Nature 362 (6415), 87-91, 1993
6501993
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway
AL Kung, SD Zabludoff, DS France, SJ Freedman, EA Tanner, A Vieira, ...
Cancer cell 6 (1), 33-43, 2004
6302004
Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α
SJ Freedman, ZYJ Sun, F Poy, AL Kung, DM Livingston, G Wagner, ...
Proceedings of the National Academy of Sciences 99 (8), 5367-5372, 2002
6102002
Structural, biochemical, and clinical characterization of epidermal growth factor receptor (EGFR) exon 20 insertion mutations in lung cancer
H Yasuda, E Park, CH Yun, NJ Sng, AR Lucena-Araujo, WL Yeo, ...
Science translational medicine 5 (216), 216ra177-216ra177, 2013
6032013
Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer
PS Hammerman, ML Sos, AH Ramos, C Xu, A Dutt, W Zhou, LE Brace, ...
Cancer discovery 1 (1), 78-89, 2011
5972011
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論文 1–20