| APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids J Zhao, Y Fu, Y Yamazaki, Y Ren, MD Davis, CC Liu, W Lu, X Wang, ... Nature communications 11 (1), 5540, 2020 | 276 | 2020 |
| Distinct hippocampal engrams control extinction and relapse of fear memory AF Lacagnina, ET Brockway, CR Crovetti, F Shue, MJ McCarty, KP Sattler, ... Nature neuroscience 22 (5), 753-761, 2019 | 272 | 2019 |
| APOE2: protective mechanism and therapeutic implications for Alzheimer’s disease Z Li, F Shue, N Zhao, M Shinohara, G Bu Molecular neurodegeneration 15 (1), 63, 2020 | 214 | 2020 |
| Alzheimer’s risk factors age, APOE genotype, and sex drive distinct molecular pathways N Zhao, Y Ren, Y Yamazaki, W Qiao, F Li, LM Felton, ... Neuron 106 (5), 727-742. e6, 2020 | 208 | 2020 |
| Dentate gyrus contributes to retrieval as well as encoding: evidence from context fear conditioning, recall, and extinction BE Bernier, AF Lacagnina, A Ayoub, F Shue, BV Zemelman, FB Krasne, ... Journal of Neuroscience 37 (26), 6359-6371, 2017 | 169 | 2017 |
| APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid N Zhao, ON Attrebi, Y Ren, W Qiao, B Sonustun, YA Martens, ... Science translational medicine 12 (529), eaay1809, 2020 | 132 | 2020 |
| Peripheral apoE4 enhances Alzheimer’s pathology and impairs cognition by compromising cerebrovascular function CC Liu, J Zhao, Y Fu, Y Inoue, Y Ren, Y Chen, SV Doss, F Shue, ... Nature neuroscience 25 (8), 1020-1033, 2022 | 109 | 2022 |
| Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer’s disease Y Inoue, F Shue, G Bu, T Kanekiyo Molecular neurodegeneration 18 (1), 46, 2023 | 100 | 2023 |
| Dorsal and ventral hippocampal adult-born neurons contribute to context fear memory KA Huckleberry, F Shue, T Copeland, RA Chitwood, W Yin, MR Drew Neuropsychopharmacology 43 (12), 2487-2496, 2018 | 96 | 2018 |
| APOE3-Jacksonville (V236E) variant reduces self-aggregation and risk of dementia CC Liu, ME Murray, X Li, N Zhao, N Wang, MG Heckman, F Shue, ... Science translational medicine 13 (613), eabc9375, 2021 | 73 | 2021 |
| Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease CC Liu, N Wang, Y Chen, Y Inoue, F Shue, Y Ren, M Wang, W Qiao, ... Nature immunology 24 (11), 1854-1866, 2023 | 58 | 2023 |
| Vascular ApoE4 impairs behavior by modulating gliovascular function Y Yamazaki, CC Liu, A Yamazaki, F Shue, YA Martens, Y Chen, W Qiao, ... Neuron 109 (3), 438-447. e6, 2021 | 54 | 2021 |
| Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination N Wang, M Wang, S Jeevaratnam, C Rosenberg, TC Ikezu, F Shue, ... Molecular neurodegeneration 17 (1), 75, 2022 | 41 | 2022 |
| A mouse model of stress-enhanced fear learning demonstrates extinction-sensitive and extinction-resistant effects of footshock stress AM Hassien, F Shue, BE Bernier, MR Drew Behavioural brain research 379, 112391, 2020 | 35 | 2020 |
| Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids J Zhao, W Lu, Y Ren, Y Fu, YA Martens, F Shue, MD Davis, X Wang, ... Acta neuropathologica 142 (5), 807-825, 2021 | 33 | 2021 |
| Activation of FAK/Rac1/Cdc42‐GTPase signaling ameliorates impaired microglial migration response to Aβ42 in triggering receptor expressed on myeloid cells 2 … Z Rong, B Cheng, L Zhong, X Ye, X Li, L Jia, Y Li, F Shue, N Wang, ... The FASEB Journal 34 (8), 10984-10997, 2020 | 32 | 2020 |
| Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology W Qiao, Y Chen, J Zhong, BJ Madden, CM Charlesworth, YA Martens, ... Molecular neurodegeneration 18 (1), 8, 2023 | 14 | 2023 |
| LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4 H Oue, Y Yamazaki, W Qiao, C Yuanxin, Y Ren, A Kurti, F Shue, ... JCI insight 8 (7), 2023 | 12 | 2023 |
| Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference CM Kloske, ME Belloy, EE Blue, GR Bowman, MC Carrillo, X Chen, ... Alzheimer's & Dementia 20 (9), 6590-6605, 2024 | 6 | 2024 |
| CSF biomarkers of immune activation and Alzheimer’s disease for predicting cognitive impairment risk in the elderly F Shue, LJ White, R Hendrix, J Ulrich, RL Henson, W Knight, YA Martens, ... Science Advances 10 (14), eadk3674, 2024 | 5 | 2024 |