| Covalent Inhibition of Wild-Type HIV-1 Reverse Transcriptase Using a Fluorosulfate Warhead JA Ippolito, H Niu, N Bertoletti, ZJ Carter, S Jin, KA Spasov, JA Cisneros, ... ACS Medicinal Chemistry Letters, 2021 | 21 | 2021 |
| Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV‐1 reverse transcriptase: First crystal structures with reverse transcriptase and … N Bertoletti, AH Chan, RF Schinazi, YW Yin, KS Anderson Protein Science 28 (9), 1664-1675, 2019 | 21 | 2019 |
| Structural and pharmacological evaluation of a novel non-nucleoside reverse transcriptase inhibitor as a promising long acting nanoformulation for treating HIV SN Kudalkar, I Ullah, N Bertoletti, HK Mandl, JA Cisneros, J Beloor, ... Antiviral research 167, 110-116, 2019 | 19 | 2019 |
| Structure-guided identification of DNMT3b inhibitors AS Newton, JC Faver, G Micevic, V Muthusamy, SN Kudalkar, N Bertoletti, ... ACS Medicinal Chemistry Letters 11 (5), 971-976, 2020 | 17 | 2020 |
| First structure–activity relationship of 17β-hydroxysteroid dehydrogenase type 14 nonsteroidal inhibitors and crystal structures in complex with the enzyme F Braun, N Bertoletti, G Möller, J Adamski, T Steinmetzer, M Salah, ... Journal of Medicinal Chemistry 59 (23), 10719-10737, 2016 | 16 | 2016 |
| New insights into human 17β-hydroxysteroid dehydrogenase type 14: first crystal structures in complex with a steroidal ligand and with a potent nonsteroidal inhibitor N Bertoletti, F Braun, M Lepage, G Möller, J Adamski, A Heine, G Klebe, ... Journal of Medicinal Chemistry 59 (14), 6961-6967, 2016 | 15 | 2016 |
| Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention SG Krimmer, N Bertoletti, Y Suzuki, L Katic, J Mohanty, S Shu, S Lee, I Lax, ... Proceedings of the National Academy of Sciences 120 (13), e2300054120, 2023 | 13 | 2023 |
| Structure-based design and profiling of novel 17β-HSD14 inhibitors F Braun, N Bertoletti, G Möller, J Adamski, M Frotscher, N Guragossian, ... European Journal of Medicinal Chemistry 155, 61-76, 2018 | 12 | 2018 |
| Mutational and structural studies uncover crucial amino acids determining activity and stability of 17β-HSD14 MJ Badran, N Bertoletti, A Keils, A Heine, G Klebe, ... The Journal of Steroid Biochemistry and Molecular Biology 189, 135-144, 2019 | 10 | 2019 |
| Structural studies and structure activity relationships for novel computationally designed non-nucleoside inhibitors and their interactions with HIV-1 reverse transcriptase KM Frey, N Bertoletti, AH Chan, JA Ippolito, M Bollini, KA Spasov, ... Frontiers in Molecular Biosciences, 114, 2022 | 9 | 2022 |
| DRONE: direct tracking of DNA cytidine deamination and other DNA modifying activities T Sasaki, SN Kudalkar, N Bertoletti, KS Anderson Analytical chemistry 90 (20), 11735-11740, 2018 | 8 | 2018 |
| Post-catalytic complexes with emtricitabine or stavudine and HIV-1 reverse transcriptase reveal new mechanistic insights for nucleotide incorporation and drug resistance N Bertoletti, AH Chan, RF Schinazi, KS Anderson Molecules 25 (20), 4868, 2020 | 6 | 2020 |
| Structural Characterization of 17β-Hydroxysteroid Dehydrogenase Type 14 and Inhibitor Optimization Using Crystallography and Computational Techniques N Bertoletti Philipps-Universität Marburg, 2018 | 2 | 2018 |
| X-ray Crystallography: essential tool for protein characterization and ligand optimization N Bertoletti, F Braun, A Metz, A Heine, G Klebe, S Marchais-Oberwinkler ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES 73, C234-C234, 2017 | 1 | 2017 |
| Compounds and methods for inhibiting type-III receptor tyrosine kinases Joseph Schlessinger, Stefan Krimmer, Nicole Bertolettii, Irit Lax WO Patent 2024155689A1, 2024 | | 2024 |
| Cryo-EM analyses of wild-type and oncogenic KIT mutants reveal structural oncogenic plasticity and a novel “Achilles heel” for therapeutic intervention SG Krimmer, N Bertoletti, Y Suzuki, L Katic, J Mohanty, S Shu, S Lee, I Lax, ... bioRxiv, 2022.09. 08.506998, 2022 | | 2022 |
| Validation of a 96-fragment library for crystallographic screening A Heine, C Siefker, N Abazi, S Gloeckner, N Bertoletti, E Hassaan, ... ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES 73, C95-C95, 2017 | | 2017 |
Gerhard KlebeProfessor für Pharmazeutische Chemie, Philipps-Universität確認したメール アドレス: mailer.uni-marburg.de