| Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma K Hu, K Li, J Lv, J Feng, J Chen, H Wu, F Cheng, W Jiang, J Wang, H Pei, ... The Journal of Clinical Investigation 130 (4), 1752-1766, 2020 | 298 | 2020 |
| Inhibition of STAT3 signaling pathway by nitidine chloride suppressed the angiogenesis and growth of human gastric cancer J Chen, J Wang, L Lin, L He, Y Wu, L Zhang, Z Yi, Y Chen, X Pang, M Liu Molecular cancer therapeutics 11 (2), 277-287, 2012 | 182 | 2012 |
| Design, synthesis, and biological evaluation of isoquinoline-1, 3, 4-trione derivatives as potent caspase-3 inhibitors YH Chen, YH Zhang, HJ Zhang, DZ Liu, M Gu, JY Li, F Wu, XZ Zhu, J Li, ... Journal of medicinal chemistry 49 (5), 1613-1623, 2006 | 152 | 2006 |
| Hispidulin, a small flavonoid molecule, suppresses the angiogenesis and growth of human pancreatic cancer by targeting vascular endothelial growth factor receptor 2‐mediated … L He, Y Wu, L Lin, J Wang, Y Wu, Y Chen, Z Yi, M Liu, X Pang Cancer science 102 (1), 219-225, 2011 | 147 | 2011 |
| A thermo-degradable hydrogel with light-tunable degradation and drug release J Hu, Y Chen, Y Li, Z Zhou, Y Cheng Biomaterials 112, 133-140, 2017 | 128 | 2017 |
| Next-generation of selective histone deacetylase inhibitors F Yang, N Zhao, D Ge, Y Chen Rsc Advances 9 (34), 19571-19583, 2019 | 126 | 2019 |
| Cucurbitacin E inhibits breast tumor metastasis by suppressing cell migration and invasion T Zhang, J Li, Y Dong, D Zhai, L Lai, F Dai, H Deng, Y Chen, M Liu, Z Yi Breast cancer research and treatment 135, 445-458, 2012 | 121 | 2012 |
| Inhibition of breast cancer metastases by a novel inhibitor of TGFβ receptor 1 Y Fang, Y Chen, L Yu, C Zheng, Y Qi, Z Li, Z Yang, Y Zhang, T Shi, J Luo, ... Journal of the National Cancer Institute 105 (1), 47-58, 2013 | 103 | 2013 |
| Plumbagin inhibits tumour angiogenesis and tumour growth through the Ras signalling pathway following activation of the VEGF receptor‐2 L Lai, J Liu, D Zhai, Q Lin, L He, Y Dong, J Zhang, B Lu, Y Chen, Z Yi, ... British journal of pharmacology 165 (4b), 1084-1096, 2012 | 101 | 2012 |
| In vivo target protein degradation induced by PROTACs based on E3 ligase DCAF15 L Li, D Mi, H Pei, Q Duan, X Wang, W Zhou, J Jin, D Li, M Liu, Y Chen Signal Transduction and Targeted Therapy 5 (1), 129, 2020 | 92 | 2020 |
| A natural small molecule harmine inhibits angiogenesis and suppresses tumour growth through activation of p53 in endothelial cells F Dai, Y Chen, Y Song, L Huang, D Zhai, Y Dong, L Lai, T Zhang, D Li, ... PloS one 7 (12), e52162, 2012 | 89 | 2012 |
| Synthesis and biological evaluation of triazol-4-ylphenyl-bearing histone deacetylase inhibitors as anticancer agents R He, Y Chen, Y Chen, AV Ougolkov, JS Zhang, DN Savoy, DD Billadeau, ... Journal of medicinal chemistry 53 (3), 1347-1356, 2010 | 87 | 2010 |
| Caffeic acid 3, 4‐dihydroxy‐phenethyl ester suppresses receptor activator of NF‐κB ligand–induced osteoclastogenesis and prevents ovariectomy‐induced bone loss through … X Wu, Z Li, Z Yang, C Zheng, J Jing, Y Chen, X Ye, X Lian, W Qiu, F Yang, ... Journal of Bone and Mineral Research 27 (6), 1298-1308, 2012 | 83 | 2012 |
| Synthesis and biological evaluation of novel tetrahydro-β-carboline derivatives as antitumor growth and metastasis agents through inhibiting the transforming growth factor-β … C Zheng, Y Fang, W Tong, G Li, H Wu, W Zhou, Q Lin, F Yang, Z Yang, ... Journal of medicinal chemistry 57 (3), 600-612, 2014 | 80 | 2014 |
| Small molecule PROTACs: an emerging technology for targeted therapy in drug discovery H Pei, Y Peng, Q Zhao, Y Chen RSC advances 9 (30), 16967-16976, 2019 | 77 | 2019 |
| Isoquinoline-1, 3, 4-trione derivatives inactivate caspase-3 by generation of reactive oxygen species JQ Du, J Wu, HJ Zhang, YH Zhang, BY Qiu, F Wu, YH Chen, JY Li, FJ Nan, ... Journal of Biological Chemistry 283 (44), 30205-30215, 2008 | 70 | 2008 |
| A small molecule targeting myoferlin exerts promising anti-tumor effects on breast cancer T Zhang, J Li, Y He, F Yang, Y Hao, W Jin, J Wu, Z Sun, Y Li, Y Chen, Z Yi, ... Nature communications 9 (1), 3726, 2018 | 66 | 2018 |
| Xanthohumol, a prenylated chalcone derived from hops, suppresses cancer cell invasion through inhibiting the expression of CXCR4 chemokine receptor Y Wang, Y Chen, J Wang, J Chen, BB Aggarwal, X Pang, M Liu Current molecular medicine 12 (2), 153-162, 2012 | 65 | 2012 |
| Searching for Disease Modifiers—PKC Activation and HDAC Inhibition—A Dual Drug Approach to Alzheimer's Disease that Decreases Aβ Production while Blocking Oxidative Stress AP Kozikowski, Y Chen, T Subhasish, NE Lewin, PM Blumberg, Z Zhong, ... ChemMedChem: Chemistry Enabling Drug Discovery 4 (7), 1095-1105, 2009 | 64 | 2009 |
| Studies of benzamide‐and thiol‐based histone deacetylase inhibitors in models of oxidative‐stress‐induced neuronal death: identification of some HDAC3‐selective inhibitors Y Chen, R He, Y Chen, MA D'Annibale, B Langley, AP Kozikowski ChemMedChem: Chemistry Enabling Drug Discovery 4 (5), 842-852, 2009 | 63 | 2009 |
