| Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System B Zetsche, JS Gootenberg, OO Abudayyeh, IM Slaymaker, KS Makarova, ... Cell 163, 1-13, 2015 | 5116 | 2015 |
| Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity FA Ran, PD Hsu, CY Lin, JS Gootenberg, S Konermann, AE Trevino, ... Cell 154 (6), 1380-1389, 2013 | 4351 | 2013 |
| Nucleic acid detection with CRISPR-Cas13a/C2c2 JS Gootenberg, OO Abudayyeh, JW Lee, P Essletzbichler, AJ Dy, J Joung, ... Science 356 (6336), 438-442, 2017 | 3286 | 2017 |
| In vivo genome editing using Staphylococcus aureus Cas9 FA Ran, L Cong, WX Yan, DA Scott, JS Gootenberg, AJ Kriz, B Zetsche, ... Nature 520 (7546), 186-191, 2015 | 3195 | 2015 |
| Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex S Konermann, MD Brigham, AE Trevino, J Joung, OO Abudayyeh, ... Nature 517 (7536), 583-588, 2015 | 3150 | 2015 |
| C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector OO Abudayyeh, JS Gootenberg, S Konermann, J Joung, IM Slaymaker, ... Science 353 (6299), aaf5573, 2016 | 2394 | 2016 |
| Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6 JS Gootenberg, OO Abudayyeh, MJ Kellner, J Joung, JJ Collins, F Zhang Science 360 (6387), 439-444, 2018 | 2276 | 2018 |
| RNA targeting with CRISPR–Cas13 OO Abudayyeh, JS Gootenberg, P Essletzbichler, S Han, J Joung, ... Nature 550 (7675), 280-284, 2017 | 2035 | 2017 |
| RNA editing with CRISPR-Cas13 DBT Cox, JS Gootenberg, OO Abudayyeh, B Franklin, MJ Kellner, J Joung, ... Science 358 (6366), 1019-1027, 2017 | 1913 | 2017 |
| Discovery and functional characterization of diverse class 2 CRISPR-Cas systems S Shmakov, OO Abudayyeh, KS Makarova, YI Wolf, JS Gootenberg, ... Molecular cell 60 (3), 385-397, 2015 | 1473 | 2015 |
| Field-deployable viral diagnostics using CRISPR-Cas13 C Myhrvold, CA Freije, JS Gootenberg, OO Abudayyeh, HC Metsky, ... Science 360 (6387), 444-448, 2018 | 1300 | 2018 |
| SHERLOCK: nucleic acid detection with CRISPR nucleases MJ Kellner, JG Koob, JS Gootenberg, OO Abudayyeh, F Zhang Nature protocols 14 (10), 2986-3012, 2019 | 1298 | 2019 |
| Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening J Joung, S Konermann, JS Gootenberg, OO Abudayyeh, RJ Platt, ... Nature protocols 12 (4), 828-863, 2017 | 1279 | 2017 |
| Diversity and evolution of class 2 CRISPR–Cas systems S Shmakov, A Smargon, D Scott, D Cox, N Pyzocha, W Yan, ... Nature reviews microbiology 15 (3), 169-182, 2017 | 1176 | 2017 |
| Engineered CRISPR-Cas9 nuclease with expanded targeting space H Nishimasu, X Shi, S Ishiguro, L Gao, S Hirano, S Okazaki, T Noda, ... Science 361 (6408), 1259-1262, 2018 | 1117 | 2018 |
| Multiplex gene editing by CRISPR–Cpf1 using a single crRNA array B Zetsche, M Heidenreich, P Mohanraju, I Fedorova, J Kneppers, ... Nature biotechnology 35 (1), 31-34, 2017 | 999 | 2017 |
| CRISPR-based diagnostics MM Kaminski, OO Abudayyeh, JS Gootenberg, F Zhang, JJ Collins Nature biomedical engineering 5 (7), 643-656, 2021 | 832 | 2021 |
| Detection of SARS-CoV-2 with SHERLOCK one-pot testing J Joung, A Ladha, M Saito, NG Kim, AE Woolley, M Segel, RPJ Barretto, ... New England Journal of Medicine 383 (15), 1492-1494, 2020 | 714 | 2020 |
| Cas13b is a type VI-B CRISPR-associated RNA-guided RNase differentially regulated by accessory proteins Csx27 and Csx28 AA Smargon, DBT Cox, NK Pyzocha, K Zheng, IM Slaymaker, ... Molecular cell 65 (4), 618-630. e7, 2017 | 642 | 2017 |
| Clinical validation of a Cas13-based assay for the detection of SARS-CoV-2 RNA M Patchsung, K Jantarug, A Pattama, K Aphicho, S Suraritdechachai, ... Nature biomedical engineering 4 (12), 1140-1149, 2020 | 571 | 2020 |
Omar O. AbudayyehAssistant Professor, Harvard Medical School確認したメール アドレス: bwh.harvard.edu