| Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 L Galluzzi, I Vitale, SA Aaronson, JM Abrams, D Adam, P Agostinis, ... Cell Death & Differentiation 25 (3), 486-541, 2018 | 6301 | 2018 |
| A hot spot of binding energy in a hormone-receptor interface T Clackson, JA Wells Science 267 (5196), 383-386, 1995 | 2608 | 1995 |
| K-Ras (G12C) inhibitors allosterically control GTP affinity and effector interactions JM Ostrem, U Peters, ML Sos, JA Wells, KM Shokat Nature 503 (7477), 548-551, 2013 | 2473 | 2013 |
| Reaching for high-hanging fruit in drug discovery at protein–protein interfaces JA Wells, CL McClendon Nature 450 (7172), 1001-1009, 2007 | 2355 | 2007 |
| High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis BC Cunningham, JA Wells Science 244 (4908), 1081-1085, 1989 | 2274 | 1989 |
| Small-molecule inhibitors of protein–protein interactions: progressing towards the dream MR Arkin, JA Wells Nature reviews Drug discovery 3 (4), 301-317, 2004 | 2112 | 2004 |
| Additivity of mutational effects in proteins JA Wells Biochemistry 29 (37), 8509-8517, 1990 | 1773 | 1990 |
| Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule BC Cunningham, M Ultsch, AM de Vos, MG Mulkerrin, KR Clauser, ... Science 254 (5033), 821-825, 1991 | 1284 | 1991 |
| Small-molecule inhibitors of protein-protein interactions: progressing toward the reality MR Arkin, Y Tang, JA Wells Chemistry & biology 21 (9), 1102-1114, 2014 | 1199 | 2014 |
| Enrichment method for variant proteins having altered binding properties, M13 phagemids, and growth hormone variants LJ Garrard, DJ Henner, S Bass, R Greene, HB Lowman, JA Wells, ... US Patent 5,750,373, 1998 | 1036 | 1998 |
| Dissecting the catalytic triad of a serine protease P Carter, JA Wells Nature 332 (6164), 564-568, 1988 | 899 | 1988 |
| Caspases and their substrates O Julien, JA Wells Cell Death & Differentiation 24 (8), 1380-1389, 2017 | 892 | 2017 |
| Rational design of potent antagonists to the human growth hormone receptor G Fuh, BC Cunningham, R Fukunaga, S Nagata, DV Goeddel, JA Wells Science 256 (5064), 1677-1680, 1992 | 892 | 1992 |
| Convergent solutions to binding at a protein-protein interface WL DeLano, MH Ultsch, AM de, n Vos, JA Wells Science 287 (5456), 1279-1283, 2000 | 881 | 2000 |
| Cassette mutagenesis: an efficient method for generation of multiple mutations at defined sites JA Wells, M Vasser, DB Powers Gene 34 (2-3), 315-323, 1985 | 813 | 1985 |
| Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis A Ordureau, SA Sarraf, DM Duda, JM Heo, MP Jedrychowski, ... Molecular cell 56 (3), 360-375, 2014 | 736 | 2014 |
| Monovalent phage display LJ Garrard, DJ Henner, S Bass, R Greene, HB Lowman, JA Wells, ... US Patent 5,821,047, 1998 | 731 | 1998 |
| Crystal structure at 1.7 Å resolution of VEGF in complex with domain 2 of the Flt-1 receptor C Wiesmann, G Fuh, HW Christinger, C Eigenbrot, JA Wells, AM de Vos Cell 91 (5), 695-704, 1997 | 703 | 1997 |
| Sexually dimorphic neurons in the ventromedial hypothalamus govern mating in both sexes and aggression in males CF Yang, MC Chiang, DC Gray, M Prabhakaran, M Alvarado, SA Juntti, ... Cell 153 (4), 896-909, 2013 | 695 | 2013 |
| Hormone phage: an enrichment method for variant proteins with altered binding properties S Bass, R Greene, JA Wells Proteins: Structure, Function, and Bioinformatics 8 (4), 309-314, 1990 | 671 | 1990 |
