| Tobacco: poisoning our planet World Health Organization World Health Organization, 2022 | 2826* | 2022 |
| Role of cytochrome P450s in insecticide resistance: impact on the control of mosquito-borne diseases and use of insecticides on Earth JP David, HM Ismail, A Chandor-Proust, MJI Paine Philosophical Transactions of the Royal Society B: Biological Sciences 368 …, 2013 | 435 | 2013 |
| Field-Caught Permethrin-Resistant Anopheles gambiae Overexpress CYP6P3, a P450 That Metabolises Pyrethroids P Müller, E Warr, BJ Stevenson, PM Pignatelli, JC Morgan, A Steven, ... PLoS genetics 4 (11), e1000286, 2008 | 389 | 2008 |
| Purification, cloning, and molecular characterization of a high molecular weight hemorrhagic metalloprotease, jararhagin, from Bothrops jararaca venom. Insights into the … MJ Paine, HP Desmond, RD Theakston, JM Crampton Journal of Biological Chemistry 267 (32), 22869-22876, 1992 | 385 | 1992 |
| CYP6 P450 Enzymes and ACE-1 Duplication Produce Extreme and Multiple Insecticide Resistance in the Malaria Mosquito Anopheles gambiae CV Edi, L Djogbenou, AM Jenkins, K Regna, MAT Muskavitch, ... PLoS genetics 10 (3), e1004236, 2014 | 346 | 2014 |
| Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed BJ Stevenson, J Bibby, P Pignatelli, S Muangnoicharoen, PM O’Neill, ... Insect biochemistry and molecular biology 41 (7), 492-502, 2011 | 282 | 2011 |
| Identification and validation of a gene causing cross-resistance between insecticide classes in Anopheles gambiae from Ghana SN Mitchell, BJ Stevenson, P Müller, CS Wilding, A Egyir-Yawson, ... Proceedings of the National Academy of Sciences 109 (16), 6147-6152, 2012 | 279 | 2012 |
| Directionally selected cytochrome P450 alleles are driving the spread of pyrethroid resistance in the major malaria vector Anopheles funestus JM Riveron, H Irving, M Ndula, KG Barnes, SS Ibrahim, MJI Paine, ... Proceedings of the National Academy of Sciences 110 (1), 252-257, 2013 | 270 | 2013 |
| Structural model and functional characterization of the Bemisia tabaci CYP6CM1vQ, a cytochrome P450 associated with high levels of imidacloprid resistance I Karunker, E Morou, D Nikou, R Nauen, R Sertchook, BJ Stevenson, ... Insect biochemistry and molecular biology 39 (10), 697-706, 2009 | 242 | 2009 |
| A model for human cytochrome P450 2D6 based on homology modeling and NMR studies of substrate binding S Modi, MJ Paine, MJ Sutcliffe, LY Lian, WU Primrose, CR Wolf, ... Biochemistry 35 (14), 4540-4550, 1996 | 223 | 1996 |
| Abamectin is metabolized by CYP392A16, a cytochrome P450 associated with high levels of acaricide resistance in Tetranychus urticae M Riga, D Tsakireli, A Ilias, E Morou, A Myridakis, EG Stephanou, ... Insect biochemistry and molecular biology 46, 43-53, 2014 | 217 | 2014 |
| Processing of pro‐tumor necrosis factor‐α by venom metalloproteinases: a hypothesis explaining local tissue damage following snake bite AM Moura‐da‐Silva, GD Laing, MJI Paine, JMTJ Dennison, V Politi, ... European journal of immunology 26 (9), 2000-2005, 1996 | 178 | 1996 |
| Nitric oxide synthases catalyze the activation of redox cycling and bioreductive anticancer agents AP Garner, MJI Paine, I Rodriguez-Crespo, EC Chinje, PO De Montellano, ... Cancer Research 59 (8), 1929-1934, 1999 | 161 | 1999 |
| Pinpointing P450s Associated with Pyrethroid Metabolism in the Dengue Vector, Aedes aegypti: Developing New Tools to Combat Insecticide Resistance BJ Stevenson, P Pignatelli, D Nikou, MJI Paine PLoS neglected tropical diseases 6 (3), e1595, 2012 | 160 | 2012 |
| Antimalarial activity of primaquine operates via a two-step biochemical relay G Camarda, P Jirawatcharadech, RS Priestley, A Saif, S March, ... Nature communications 10 (1), 3226, 2019 | 151 | 2019 |
| Anopheles gambiae P450 reductase is highly expressed in oenocytes and in vivo knockdown increases permethrin susceptibility GJ Lycett, LA McLaughlin, H Ranson, J Hemingway, FC Kafatos, ... Insect molecular biology 15 (3), 321-327, 2006 | 145 | 2006 |
| Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 m RNA in human foetal and adult brain by in situ hybridization DE Gilham, W Cairns, MJI Paine, S Modi, R Poulsom, GCK Roberts, ... Xenobiotica 27 (1), 111-125, 1997 | 144 | 1997 |
| Metabolic and Target-Site Mechanisms Combine to Confer Strong DDT Resistance in Anopheles gambiae SN Mitchell, DJ Rigden, AJ Dowd, F Lu, CS Wilding, D Weetman, ... PloS one 9 (3), e92662, 2014 | 140 | 2014 |
| Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6 MJI Paine, LA McLaughlin, JU Flanagan, CA Kemp, MJ Sutcliffe, ... Journal of Biological Chemistry 278 (6), 4021-4027, 2003 | 140 | 2003 |
| Engineering of a functional human NADH-dependent cytochrome P450 system O Döhr, MJI Paine, T Friedberg, GCK Roberts, CR Wolf Proceedings of the National Academy of Sciences 98 (1), 81-86, 2001 | 135 | 2001 |
Mike SutcliffeHead of School of Engineering, Arden University確認したメール アドレス: arden.ac.uk