| Interconnected microphysiological systems for quantitative biology and pharmacology studies CD Edington, WLK Chen, E Geishecker, T Kassis, LR Soenksen, ... Scientific reports 8 (1), 4530, 2018 | 464 | 2018 |
| Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing U Marx, TB Andersson, A Bahinski, M Beilmann, S Beken, FR Cassee, ... Altex 33 (3), 272, 2016 | 357 | 2016 |
| Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development U Marx, T Akabane, TB Andersson, E Baker, M Beilmann, S Beken, ... Altex 37 (3), 365, 2020 | 270 | 2020 |
| Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies N Tsamandouras, WLK Chen, CD Edington, CL Stokes, LG Griffith, M Cirit The AAPS journal 19, 1499-1512, 2017 | 197 | 2017 |
| Integrated gut/liver microphysiological systems elucidates inflammatory inter‐tissue crosstalk WLK Chen, C Edington, E Suter, J Yu, JJ Velazquez, JG Velazquez, ... Biotechnology and bioengineering 114 (11), 2648-2659, 2017 | 168 | 2017 |
| Quantitative assessment of population variability in hepatic drug metabolism using a perfused three-dimensional human liver microphysiological system N Tsamandouras, T Kostrzewski, CL Stokes, LG Griffith, DJ Hughes, ... The Journal of pharmacology and experimental therapeutics 360 (1), 95-105, 2017 | 113 | 2017 |
| Allosteric modulation of Ras-GTP is linked to signal transduction through RAF kinase G Buhrman, VSS Kumar, M Cirit, JM Haugh, C Mattos Journal of Biological chemistry 286 (5), 3323-3331, 2011 | 107 | 2011 |
| Systematic quantification of negative feedback mechanisms in the extracellular signal-regulated kinase (ERK) signaling network M Cirit, CC Wang, JM Haugh Journal of Biological Chemistry 285 (47), 36736-36744, 2010 | 102 | 2010 |
| PI3K‐dependent cross‐talk interactions converge with Ras as quantifiable inputs integrated by Erk CC Wang, M Cirit, JM Haugh Molecular systems biology 5 (1), 246, 2009 | 97 | 2009 |
| Integrated assessment of diclofenac biotransformation, pharmacokinetics, and omics-based toxicity in a three-dimensional human liver-immunocompetent coculture system U Sarkar, KC Ravindra, E Large, CL Young, D Rivera-Burgos, J Yu, ... Drug Metabolism and Disposition 45 (7), 855-866, 2017 | 74 | 2017 |
| Multi-functional scaling methodology for translational pharmacokinetic and pharmacodynamic applications using integrated microphysiological systems (MPS) C Maass, CL Stokes, LG Griffith, M Cirit Integrative Biology 9 (4), 290-302, 2017 | 74 | 2017 |
| Stochastic model of integrin-mediated signaling and adhesion dynamics at the leading edges of migrating cells M Cirit, M Krajcovic, CK Choi, ES Welf, AF Horwitz, JM Haugh PLoS computational biology 6 (2), e1000688, 2010 | 74 | 2010 |
| Maximizing the impact of microphysiological systems with in vitro–in vivo translation M Cirit, CL Stokes Lab on a Chip 18 (13), 1831-1837, 2018 | 70 | 2018 |
| Data‐driven modeling reconciles kinetics of ERK phosphorylation, localization, and activity states S Ahmed, KG Grant, LE Edwards, A Rahman, M Cirit, MB Goshe, ... Molecular systems biology 10 (1), 718, 2014 | 65 | 2014 |
| Translational assessment of drug‐induced proximal tubule injury using a kidney microphysiological system C Maass, NB Sorensen, J Himmelfarb, EJ Kelly, CL Stokes, M Cirit CPT: pharmacometrics & systems pharmacology 8 (5), 316-325, 2019 | 63 | 2019 |
| Physiome‐on‐a‐chip: the challenge of “scaling” in design, operation, and translation of microphysiological systems CL Stokes, M Cirit, DA Lauffenburger CPT: pharmacometrics & systems pharmacology 4 (10), 559-562, 2015 | 54 | 2015 |
| Quantitative systems pharmacology approaches applied to microphysiological systems (MPS): data interpretation and multi‐MPS integration J Yu, NA Cilfone, EM Large, U Sarkar, JS Wishnok, SR Tannenbaum, ... CPT: Pharmacometrics & Systems Pharmacology 4 (10), 585-594, 2015 | 53 | 2015 |
| Analysis of an integrated human multiorgan microphysiological system for combined tolcapone metabolism and brain metabolomics X Wang, M Cirit, JS Wishnok, LG Griffith, SR Tannenbaum Analytical Chemistry 91 (13), 8667-8675, 2019 | 43 | 2019 |
| Establishing quasi-steady state operations of microphysiological systems (MPS) using tissue-specific metabolic dependencies C Maass, M Dallas, ME LaBarge, M Shockley, J Valdez, E Geishecker, ... Scientific Reports 8 (1), 8015, 2018 | 34 | 2018 |
| Data-driven modelling of receptor tyrosine kinase signalling networks quantifies receptor-specific potencies of PI3K-and Ras-dependent ERK activation M Cirit, JM Haugh Biochemical Journal 441 (1), 77-85, 2012 | 28 | 2012 |