| Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease LTJ Hickson, LGPL Prata, SA Bobart, TK Evans, N Giorgadze, SK Hashmi, ... EBioMedicine 47, 446-456, 2019 | 1050 | 2019 |
| Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence R Anderson, A Lagnado, D Maggiorani, A Walaszczyk, E Dookun, ... The EMBO journal 38 (5), e100492, 2019 | 456 | 2019 |
| Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence MG Vizioli, T Liu, KN Miller, NA Robertson, K Gilroy, AB Lagnado, ... Genes & development 34 (5-6), 428-445, 2020 | 284 | 2020 |
| Apoptotic stress causes mtDNA release during senescence and drives the SASP S Victorelli, H Salmonowicz, J Chapman, H Martini, MG Vizioli, JS Riley, ... Nature 622 (7983), 627-636, 2023 | 231 | 2023 |
| Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction S Victorelli, A Lagnado, J Halim, W Moore, D Talbot, K Barrett, J Chapman, ... The EMBO journal 38 (23), e101982, 2019 | 204 | 2019 |
| NFκB1 is a suppressor of neutrophil-driven hepatocellular carcinoma CL Wilson, D Jurk, N Fullard, P Banks, A Page, S Luli, AM Elsharkawy, ... Nature communications 6 (1), 6818, 2015 | 188 | 2015 |
| Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner A Lagnado, J Leslie, MH Ruchaud‐Sparagano, S Victorelli, P Hirsova, ... The EMBO journal 40 (9), e106048, 2021 | 163 | 2021 |
| Characterization of cellular senescence in aging skeletal muscle X Zhang, L Habiballa, Z Aversa, YE Ng, AE Sakamoto, DA Englund, ... Nature Aging 2 (7), 601-615, 2022 | 120 | 2022 |
| Targeted reduction of senescent cell burden alleviates focal radiotherapy‐related bone loss A Chandra, AB Lagnado, JN Farr, DG Monroe, S Park, C Hachfeld, ... Journal of Bone and Mineral Research 35 (6), 1119-1131, 2020 | 111 | 2020 |
| Corrigendum to ‘Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease … LTJ Hickson, LGPL Prata, SA Bobart, TK Evans, N Giorgadze, SK Hashmi, ... EBioMedicine 52, 2020 | 106 | 2020 |
| Accelerated osteocyte senescence and skeletal fragility in mice with type 2 diabetes BA Eckhardt, JL Rowsey, BS Thicke, DG Fraser, KL O’Grady, OP Bondar, ... JCI insight 5 (9), 2020 | 95 | 2020 |
| Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk LD Cassidy, ARJ Young, CNJ Young, EJ Soilleux, E Fielder, BM Weigand, ... Nature communications 11 (1), 307, 2020 | 90 | 2020 |
| NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health Brown University TDA Wang Siyuan (Steven) 34, ... Nature aging 2 (12), 1090-1100, 2022 | 80 | 2022 |
| Targeted clearance of p21‐ but not p16‐positive senescent cells prevents radiation‐induced osteoporosis and increased marrow adiposity A Chandra, AB Lagnado, JN Farr, M Doolittle, T Tchkonia, JL Kirkland, ... Aging Cell 21 (5), e13602, 2022 | 77 | 2022 |
| Rapamycin improves healthspan but not inflammaging in nfκb1−/− mice C Correia‐Melo, J Birch, E Fielder, D Rahmatika, J Taylor, J Chapman, ... Aging cell 18 (1), e12882, 2019 | 77 | 2019 |
| Spatial mapping of cellular senescence: emerging challenges and opportunities AU Gurkar, AA Gerencser, AL Mora, AC Nelson, AR Zhang, AB Lagnado, ... Nature aging 3 (7), 776-790, 2023 | 64 | 2023 |
| Local senolysis in aged mice only partially replicates the benefits of systemic senolysis JN Farr, D Saul, ML Doolittle, J Kaur, JL Rowsey, SJ Vos, MN Froemming, ... The Journal of clinical investigation 133 (8), 2023 | 45 | 2023 |
| Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence I Fernández-Duran, A Quintanilla, N Tarrats, J Birch, P Hari, FR Millar, ... Cell Death & Differentiation 29 (6), 1267-1282, 2022 | 27 | 2022 |
| Bone marrow adiposity in models of radiation‐and aging‐related bone loss is dependent on cellular senescence A Chandra, AB Lagnado, JN Farr, M Schleusner, DG Monroe, D Saul, ... Journal of Bone and Mineral Research 37 (5), 997-1011, 2020 | 26 | 2020 |
| Cellular senescence is increased in airway smooth muscle cells of elderly persons with asthma A Aghali, L Khalfaoui, AB Lagnado, LY Drake, JJ Teske, CM Pabelick, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 323 (5 …, 2022 | 23 | 2022 |
