| Disease variant prediction with deep generative models of evolutionary data J Frazer, P Notin, M Dias, A Gomez, JK Min, K Brock, Y Gal, DS Marks Nature 599 (7883), 91-95, 2021 | 578 | 2021 |
| The EVcouplings Python framework for coevolutionary sequence analysis TA Hopf, AG Green, B Schubert, S Mersmann, CPI Schärfe, JB Ingraham, ... Bioinformatics 35 (9), 1582-1584, 2019 | 250 | 2019 |
| Cryo–electron microscopy structure of the lipid droplet–formation protein seipin X Sui, H Arlt, KP Brock, ZW Lai, F DiMaio, DS Marks, M Liao, RV Farese Jr, ... Journal of Cell Biology 217 (12), 4080-4091, 2018 | 193 | 2018 |
| Inferring protein 3D structure from deep mutation scans NJ Rollins, KP Brock, FJ Poelwijk, MA Stiffler, NP Gauthier, C Sander, ... Nature genetics 51 (7), 1170-1176, 2019 | 165 | 2019 |
| Structure of the peptidoglycan polymerase RodA resolved by evolutionary coupling analysis M Sjodt, K Brock, G Dobihal, PDA Rohs, AG Green, TA Hopf, AJ Meeske, ... Nature 556 (7699), 118-121, 2018 | 139 | 2018 |
| Structural coordination of polymerization and crosslinking by a SEDS–bPBP peptidoglycan synthase complex M Sjodt, PDA Rohs, MSA Gilman, SC Erlandson, S Zheng, AG Green, ... Nature microbiology 5 (6), 813-820, 2020 | 119 | 2020 |
| Large-scale discovery of protein interactions at residue resolution using co-evolution calculated from genomic sequences AG Green, H Elhabashy, KP Brock, R Maddamsetti, O Kohlbacher, ... Nature communications 12 (1), 1396, 2021 | 100 | 2021 |
| Structure and mutagenic analysis of the lipid II flippase MurJ from Escherichia coli S Zheng, LT Sham, FA Rubino, KP Brock, WP Robins, JJ Mekalanos, ... Proceedings of the National Academy of Sciences 115 (26), 6709-6714, 2018 | 82 | 2018 |
| Optimization of electrostatic interactions in protein-protein complexes K Brock, K Talley, K Coley, P Kundrotas, E Alexov Biophysical journal 93 (10), 3340-3352, 2007 | 67 | 2007 |
| Protein structure from experimental evolution MA Stiffler, FJ Poelwijk, KP Brock, RR Stein, A Riesselman, J Teyra, ... Cell Systems 10 (1), 15-24. e5, 2020 | 43 | 2020 |
| PDBe-KB: collaboratively defining the biological context of structural data Nucleic acids research 50 (D1), D534-D542, 2022 | 42 | 2022 |
| Bacterial spore germination receptors are nutrient-gated ion channels Y Gao, JD Amon, L Artzi, FH Ramírez-Guadiana, KP Brock, JC Cofsky, ... Science 380 (6643), 387-391, 2023 | 36 | 2023 |
| Dormant spores sense amino acids through the B subunits of their germination receptors L Artzi, A Alon, KP Brock, AG Green, A Tam, FH Ramírez-Guadiana, ... Nature Communications 12 (1), 6842, 2021 | 36 | 2021 |
| The SpoVA membrane complex is required for dipicolinic acid import during sporulation and export during germination Y Gao, RDC Barajas-Ornelas, JD Amon, FH Ramírez-Guadiana, A Alon, ... Genes & Development 36 (9-10), 634-646, 2022 | 31 | 2022 |
| Mechanical gating of the auditory transduction channel TMC1 involves the fourth and sixth transmembrane helices N Akyuz, KD Karavitaki, B Pan, PI Tamvakologos, KP Brock, Y Li, ... Science Advances 8 (28), eabo1126, 2022 | 21 | 2022 |
| Protein structure prediction assisted with sparse NMR data in CASP13 D Sala, YJ Huang, CA Cole, DA Snyder, G Liu, Y Ishida, GVT Swapna, ... Proteins: Structure, Function, and Bioinformatics 87 (12), 1315-1332, 2019 | 21 | 2019 |
| Structural coordination of polymerization and crosslinking by a SEDS-bPBP peptidoglycan synthase complex. Nat Microbiol 5: 813–820 M Sjodt, PDA Rohs, MSA Gilman, SC Erlandson, S Zheng, AG Green, ... | 19 | 2020 |
| Evidence that regulation of intramembrane proteolysis is mediated by substrate gating during sporulation in Bacillus subtilis FH Ramírez-Guadiana, CDA Rodrigues, KA Marquis, N Campo, ... PLoS Genetics 14 (11), e1007753, 2018 | 19 | 2018 |
| Large-scale clinical interpretation of genetic variants using evolutionary data and deep learning J Frazer, P Notin, M Dias, A Gomez, K Brock, Y Gal, DS Marks bioRxiv, 2020.12. 21.423785, 2020 | 16 | 2020 |
| Natural and designed proteins inspired by extremotolerant organisms can form condensates and attenuate apoptosis in human cells MT Veling, DT Nguyen, NN Thadani, ME Oster, NJ Rollins, KP Brock, ... ACS synthetic biology 11 (3), 1292-1302, 2022 | 15 | 2022 |