フォロー
Philip Jewsbury
Philip Jewsbury
AstraZeneca Pharmaceuticals
確認したメール アドレス: wasabi1.plus.com
タイトル
引用先
引用先
A review of protein-small molecule docking methods
RD Taylor, PJ Jewsbury, JW Essex
Journal of computer-aided molecular design 16, 151-166, 2002
10482002
Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor
TG Davies, J Bentley, CE Arris, FT Boyle, NJ Curtin, JA Endicott, ...
Nature structural biology 9 (10), 745-749, 2002
2842002
Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles
CE Arris, FT Boyle, AH Calvert, NJ Curtin, JA Endicott, EF Garman, ...
Journal of medicinal chemistry 43 (15), 2797-2804, 2000
2742000
Discovery and characterization of AZD6738, a potent inhibitor of ataxia telangiectasia mutated and Rad3 related (ATR) kinase with application as an anticancer agent
KM Foote, JWM Nissink, T McGuire, P Turner, S Guichard, JWT Yates, ...
Journal of medicinal chemistry 61 (22), 9889-9907, 2018
2652018
Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): A Potent and Selective Inhibitor of ATR Protein …
KM Foote, K Blades, A Cronin, S Fillery, SS Guichard, L Hassall, I Hickson, ...
Journal of medicinal chemistry 56 (5), 2125-2138, 2013
2562013
Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo
S Ashton, YH Song, J Nolan, E Cadogan, J Murray, R Odedra, J Foster, ...
Science translational medicine 8 (325), 325ra17-325ra17, 2016
2292016
N2-substituted O 6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2
IR Hardcastle, CE Arris, J Bentley, FT Boyle, Y Chen, NJ Curtin, ...
Journal of medicinal chemistry 47 (15), 3710-3722, 2004
1582004
Imidazo [1, 2-a] pyridines: a potent and selective class of cyclin-dependent kinase inhibitors identified through structure-based hybridisation
M Anderson, JF Beattie, GA Breault, J Breed, KF Byth, JD Culshaw, ...
Bioorganic & Medicinal Chemistry Letters 13 (18), 3021-3026, 2003
1522003
FDS: flexible ligand and receptor docking with a continuum solvent model and soft‐core energy function
RD Taylor, PJ Jewsbury, JW Essex
Journal of computational chemistry 24 (13), 1637-1656, 2003
1292003
Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 1: identification and optimisation of substituted 4, 6-bis anilino pyrimidines
JF Beattie, GA Breault, RPA Ellston, S Green, PJ Jewsbury, CJ Midgley, ...
Bioorganic & medicinal chemistry letters 13 (18), 2955-2960, 2003
1142003
Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O 6-substituted guanine derivatives
AE Gibson, CE Arris, J Bentley, FT Boyle, NJ Curtin, TG Davies, ...
Journal of medicinal chemistry 45 (16), 3381-3393, 2002
1112002
Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2
KL Sayle, J Bentley, FT Boyle, AH Calvert, Y Cheng, NJ Curtin, ...
Bioorganic & medicinal chemistry letters 13 (18), 3079-3082, 2003
942003
The proximal residue largely determines the CO distortion in carbon monoxy globin proteins. An ab initio study of a heme prosthetic unit
P Jewsbury, S Yamamoto, T Minato, M Saito, T Kitagawa
The Journal of Physical Chemistry 99 (33), 12677-12685, 1995
831995
Novel, potent and selective anilinoquinazoline and anilinopyrimidine inhibitors of p38 MAP kinase
JG Cumming, CL McKenzie, SG Bowden, D Campbell, DJ Masters, ...
Bioorganic & medicinal chemistry letters 14 (21), 5389-5394, 2004
752004
4-Alkoxy-2, 6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2
V Mesguiche, RJ Parsons, CE Arris, J Bentley, FT Boyle, NJ Curtin, ...
Bioorganic & medicinal chemistry letters 13 (2), 217-222, 2003
752003
The distal residue-CO interaction in carbonmonoxy myoglobins: a molecular dynamics study of two distal histidine tautomers
P Jewsbury, T Kitagawa
Biophysical journal 67 (6), 2236-2250, 1994
651994
Einstein A-coefficients and transition dipole moments for some ion-pair to valence transitions in I2
K Lawley, P Jewsbury, T Ridley, P Langridge-Smith, R Donovan
Molecular Physics 75 (4), 811-828, 1992
651992
Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 2: identification and optimisation of substituted 2, 4-bis anilino pyrimidines
GA Breault, RPA Ellston, S Green, SR James, PJ Jewsbury, CJ Midgley, ...
Bioorganic & medicinal chemistry letters 13 (18), 2961-2966, 2003
642003
REPLACE: a strategy for iterative design of cyclin‐binding groove inhibitors
MJI Andrews, G Kontopidis, C McInnes, A Plater, L Innes, A Cowan, ...
ChemBioChem 7 (12), 1909-1915, 2006
632006
A novel systemically administered toll‐like receptor 7 agonist potentiates the effect of ionizing radiation in murine solid tumor models
AL Adlard, SJ Dovedi, BA Telfer, E Koga‐Yamakawa, C Pollard, ...
International journal of cancer 135 (4), 820-829, 2014
572014
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