| Structural analysis reveals that toll-like receptor 7 is a dual receptor for guanosine and single-stranded RNA Z Zhang, U Ohto, T Shibata, E Krayukhina, M Taoka, Y Yamauchi, H Tanji, ... Immunity 45 (4), 737-748, 2016 | 467 | 2016 |
| Structure of SARS-CoV-2 membrane protein essential for virus assembly Z Zhang, N Nomura, Y Muramoto, T Ekimoto, T Uemura, K Liu, M Yui, ... Nature communications 13 (1), 4399, 2022 | 179 | 2022 |
| Structural analyses of toll-like receptor 7 reveal detailed RNA sequence specificity and recognition mechanism of agonistic ligands Z Zhang, U Ohto, T Shibata, M Taoka, Y Yamauchi, R Sato, NM Shukla, ... Cell reports 25 (12), 3371-3381. e5, 2018 | 152 | 2018 |
| Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation U Ohto, Y Kamitsukasa, H Ishida, Z Zhang, K Murakami, C Hirama, ... Proceedings of the National Academy of Sciences 119 (11), e2121353119, 2022 | 84 | 2022 |
| Structure of the bile acid transporter and HBV receptor NTCP J Asami, KT Kimura, Y Fujita-Fujiharu, H Ishida, Z Zhang, Y Nomura, K Liu, ... Nature 606 (7916), 1021-1026, 2022 | 76 | 2022 |
| Cryo-EM structures of Toll-like receptors in complex with UNC93B1 H Ishida, J Asami, Z Zhang, T Nishizawa, H Shigematsu, U Ohto, ... Nature Structural & Molecular Biology 28 (2), 173-180, 2021 | 64 | 2021 |
| Structural analysis reveals TLR7 dynamics underlying antagonism S Tojo, Z Zhang, H Matsui, M Tahara, M Ikeguchi, M Kochi, M Kamada, ... Nature communications 11 (1), 5204, 2020 | 54 | 2020 |
| Toward a structural understanding of nucleic acid‐sensing Toll‐like receptors in the innate immune system Z Zhang, U Ohto, T Shimizu FEBS letters 591 (20), 3167-3181, 2017 | 40 | 2017 |
| Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome Z Zhang, T Shibata, A Fujimura, J Kitaura, K Miyake, U Ohto, T Shimizu Nature 622 (7981), 188-194, 2023 | 25 | 2023 |
| Improving particle quality in cryo-EM analysis using a PEGylation method Z Zhang, H Shigematsu, T Shimizu, U Ohto Structure 29 (10), 1192-1199. e4, 2021 | 25 | 2021 |
| A novel Toll-like receptor 7/8–specific antagonist E6742 ameliorates clinically relevant disease parameters in murine models of lupus ST Ishizaka, L Hawkins, Q Chen, F Tago, T Yagi, K Sakaniwa, Z Zhang, ... European Journal of Pharmacology 957, 175962, 2023 | 9 | 2023 |
| Propofol directly binds to and inhibits TLR7 S Koutsogiannaki, W Bu, W Maisat, M Manzor, Z Zhang, U Ohto, ... The FASEB Journal 36 (8), e22481, 2022 | 2 | 2022 |
| Architecture of the high-affinity immunoglobulin E receptor Z Zhang, M Yui, U Ohto, T Shimizu Science Signaling 17 (866), eadn1303, 2024 | 1 | 2024 |
| Targeting toll-like receptor 7 as a therapeutic development strategy for systemic lupus erythematosus M Wang, H Chen, T Zhang, Z Zhang, X Xiang, M Gao, Y Guo, S Jiang, ... Acta Pharmaceutica Sinica B 14 (11), 4899-4913, 2024 | 1 | 2024 |
| Cryo‐EM structures of the zinc transporters ZnT3 and ZnT4 provide insights into their transport mechanisms H Ishida, R Yo, Z Zhang, T Shimizu, U Ohto FEBS letters, 2024 | 1 | 2024 |
| The structures of the peptide transporters SLC15A3 and SLC15A4 reveal the recognition mechanisms for substrate and TASL Z Zhang, S Kasai, K Sakaniwa, A Fujimura, U Ohto, T Shimizu Structure 33 (2), 330-337. e4, 2025 | | 2025 |
| Synergistic Activation of TLR7 and 8 Mediated by Reduction of Electrostatic Repulsion T Ekimoto, M Nomura, Y Saito, M Suzuki, T Yamane, Z Zhang, U Ohto, ... Chemical and Pharmaceutical Bulletin 72 (11), 1005-1013, 2024 | | 2024 |
| Structural Studies of Toll-like Receptor 7 Z Zhang, U Ohto, T Shimizu ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES 73, A342-A342, 2017 | | 2017 |
| SI Correction: Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation U Ohto, Y Kamitsukasa, H Ishida, Z Zhang, K Murakami, C Hirama, ... | | |
