COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study LYW Lee, JB Cazier, V Angelis, R Arnold, V Bisht, NA Campton, ... The Lancet 395 (10241), 1919-1926, 2020 | 1276 | 2020 |
Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas C Palles, JB Cazier, KM Howarth, E Domingo, AM Jones, P Broderick, ... Nature genetics 45 (2), 136-144, 2013 | 1126 | 2013 |
COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study LYW Lee, JB Cazier, T Starkey, SEW Briggs, R Arnold, V Bisht, S Booth, ... The Lancet Oncology 21 (10), 1309-1316, 2020 | 669 | 2020 |
Clinical relevance of DPYD variants c. 1679T> G, c. 1236G> A/HapB3, and c. 1601G> A as predictors of severe fluoropyrimidine-associated toxicity: a systematic review and meta … D Meulendijks, LM Henricks, GS Sonke, MJ Deenen, TK Froehlich, ... The Lancet Oncology 16 (16), 1639-1650, 2015 | 417 | 2015 |
DNA polymerase ɛ and δ exonuclease domain mutations in endometrial cancer DN Church, SEW Briggs, C Palles, E Domingo, SJ Kearsey, JM Grimes, ... Human molecular genetics 22 (14), 2820-2828, 2013 | 415 | 2013 |
A panoply of errors: polymerase proofreading domain mutations in cancer E Rayner, IC Van Gool, C Palles, SE Kearsey, T Bosse, I Tomlinson, ... Nature Reviews Cancer 16 (2), 71-81, 2016 | 366 | 2016 |
POLE proofreading mutations elicit an antitumor immune response in endometrial cancer IC van Gool, FA Eggink, L Freeman-Mills, E Stelloo, E Marchi, M de Bruyn, ... Clinical Cancer Research 21 (14), 3347-3355, 2015 | 329 | 2015 |
Novel breast cancer susceptibility locus at 9q31. 2: results of a genome-wide association study O Fletcher, N Johnson, N Orr, FJ Hosking, LJ Gibson, K Walker, ... Journal of the National Cancer Institute 103 (5), 425-435, 2011 | 300 | 2011 |
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk MG Dunlop, SE Dobbins, SM Farrington, AM Jones, C Palles, N Whiffin, ... Nature genetics 44 (7), 770-776, 2012 | 289 | 2012 |
Genetic markers of toxicity from capecitabine and other fluorouracil-based regimens: investigation in the QUASAR2 study, systematic review, and meta-analysis D Rosmarin, C Palles, D Church, E Domingo, A Jones, E Johnstone, ... Journal of Clinical Oncology 32 (10), 1031-1039, 2014 | 281 | 2014 |
Identification of nine new susceptibility loci for endometrial cancer TA O’mara, DM Glubb, F Amant, D Annibali, K Ashton, J Attia, PL Auer, ... Nature communications 9 (1), 3166, 2018 | 240 | 2018 |
Multiple Common Susceptibility Variants near BMP Pathway Loci GREM1, BMP4, and BMP2 Explain Part of the Missing Heritability of Colorectal Cancer IPM Tomlinson, LG Carvajal-Carmona, SE Dobbins, A Tenesa, AM Jones, ... PLoS genetics 7 (6), e1002105, 2011 | 240 | 2011 |
Association analyses identify 31 new risk loci for colorectal cancer susceptibility PJ Law, M Timofeeva, C Fernandez-Rozadilla, P Broderick, J Studd, ... Nature communications 10 (1), 2154, 2019 | 235 | 2019 |
Common variants at the MHC locus and at chromosome 16q24. 1 predispose to Barrett's esophagus Esophageal Adenocarcinoma Genetics Consortium, ... Nature genetics 44 (10), 1131-1136, 2012 | 210 | 2012 |
Genome-wide association studies in oesophageal adenocarcinoma and Barrett's oesophagus: a large-scale meta-analysis P Gharahkhani, RC Fitzgerald, TL Vaughan, C Palles, I Gockel, ... The lancet oncology 17 (10), 1363-1373, 2016 | 189 | 2016 |
Mutational signature analysis reveals NTHL1 deficiency to cause a multi-tumor phenotype JE Grolleman, RM De Voer, FA Elsayed, M Nielsen, RDA Weren, C Palles, ... Cancer cell 35 (2), 256-266. e5, 2019 | 177 | 2019 |
Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis N Whiffin, FJ Hosking, SM Farrington, C Palles, SE Dobbins, L Zgaga, ... Human molecular genetics 23 (17), 4729-4737, 2014 | 173 | 2014 |
Rare disruptive mutations and their contribution to the heritable risk of colorectal cancer D Chubb, P Broderick, SE Dobbins, M Frampton, B Kinnersley, S Penegar, ... Nature communications 7 (1), 11883, 2016 | 165 | 2016 |
Counting potentially functional variants in BRCA1, BRCA2 and ATM predicts breast cancer susceptibility N Johnson, O Fletcher, C Palles, M Rudd, E Webb, G Sellick, ... Human molecular genetics 16 (9), 1051-1057, 2007 | 159 | 2007 |
A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer NA Al-Tassan, N Whiffin, FJ Hosking, C Palles, SM Farrington, ... Scientific reports 5 (1), 10442, 2015 | 145 | 2015 |