| Differential Kv1. 3, KCa3. 1, and Kir2. 1 expression in “classically” and “alternatively” activated microglia HM Nguyen, EM Grössinger, M Horiuchi, KW Davis, LW Jin, I Maezawa, ... Glia 65 (1), 106-121, 2017 | 152 | 2017 |
| Durable pharmacological responses from the peptide ShK-186, a specific Kv1. 3 channel inhibitor that suppresses T cell mediators of autoimmune disease EJ Tarcha, V Chi, EJ Muñoz-Elías, D Bailey, LM Londono, SK Upadhyay, ... The Journal of pharmacology and experimental therapeutics 342 (3), 642-653, 2012 | 142 | 2012 |
| Kv1. 3 modulates neuroinflammation and neurodegeneration in Parkinson’s disease S Sarkar, HM Nguyen, E Malovic, J Luo, M Langley, BN Palanisamy, ... The Journal of clinical investigation 130 (8), 4195-4212, 2020 | 124 | 2020 |
| Kv1.3 inhibition as a potential microglia-targeted therapy for Alzheimer’s disease: preclinical proof of concept I Maezawa, HM Nguyen, J Di Lucente, DP Jenkins, V Singh, S Hilt, K Kim, ... Brain 141 (2), 596-612, 2018 | 104 | 2018 |
| The voltage‐gated potassium channel Kv1.3 is required for microglial pro‐inflammatory activation in vivo J Di Lucente, HM Nguyen, H Wulff, LW Jin, I Maezawa Glia 66 (9), 1881-1895, 2018 | 98 | 2018 |
| The potassium channel KCa3. 1 constitutes a pharmacological target for neuroinflammation associated with ischemia/reperfusion stroke YJ Chen, HM Nguyen, I Maezawa, EM Grössinger, AL Garing, R Köhler, ... Journal of Cerebral Blood Flow & Metabolism 36 (12), 2146-2161, 2016 | 97 | 2016 |
| Kv1. 3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases S Chhabra, SC Chang, HM Nguyen, R Huq, MR Tanner, LM Londono, ... The FASEB Journal 28 (9), 3952, 2014 | 93 | 2014 |
| Kv1. 3 deletion biases T cells toward an immunoregulatory phenotype and renders mice resistant to autoimmune encephalomyelitis AR Gocke, LA Lebson, IV Grishkan, L Hu, HM Nguyen, KA Whartenby, ... The Journal of Immunology 188 (12), 5877-5886, 2012 | 83 | 2012 |
| Modulation of voltage-gated K+ channels by the sodium channel β1 subunit HM Nguyen, H Miyazaki, N Hoshi, BJ Smith, N Nukina, AL Goldin, ... Proceedings of the National Academy of Sciences 109 (45), 18577-18582, 2012 | 82 | 2012 |
| Repurposing the KCa3. 1 inhibitor senicapoc for Alzheimer's disease LW Jin, JD Lucente, HM Nguyen, V Singh, L Singh, M Chavez, T Bushong, ... Annals of clinical and translational neurology 6 (4), 723-738, 2019 | 62 | 2019 |
| Structural insights into the atomistic mechanisms of action of small molecule inhibitors targeting the KCa3. 1 channel pore HM Nguyen, V Singh, B Pressly, DP Jenkins, H Wulff, V Yarov-Yarovoy Molecular pharmacology 91 (4), 392-402, 2017 | 56 | 2017 |
| Inhibition of the potassium channel Kv1. 3 reduces infarction and inflammation in ischemic stroke YJ Chen, HM Nguyen, I Maezawa, LW Jin, H Wulff Annals of clinical and translational neurology 5 (2), 147-161, 2018 | 54 | 2018 |
| Potassium channel expression and function in microglia: Plasticity and possible species variations HM Nguyen, LV Blomster, P Christophersen, H Wulff Channels 11 (4), 305-315, 2017 | 51 | 2017 |
| Domain structure and function of matrix metalloprotease 23 (MMP23): role in potassium channel trafficking CA Galea, HM Nguyen, K George Chandy, BJ Smith, RS Norton Cellular and Molecular Life Sciences 71, 1191-1210, 2014 | 50 | 2014 |
| Nanomolar bifenthrin alters synchronous Ca2+ oscillations and cortical neuron development independent of sodium channel activity Z Cao, Y Cui, HM Nguyen, DP Jenkins, H Wulff, IN Pessah Molecular Pharmacology 85 (4), 630-639, 2014 | 49 | 2014 |
| Biophysical basis for Kv1. 3 regulation of membrane potential changes induced by P2X4‐mediated calcium entry in microglia HM Nguyen, J di Lucente, YJ Chen, Y Cui, RH Ibrahim, MW Pennington, ... Glia 68 (11), 2377-2394, 2020 | 48 | 2020 |
| The riluzole derivative 2-amino-6-trifluoromethylthio-benzothiazole (SKA-19), a mixed KCa2 activator and NaV blocker, is a potent novel anticonvulsant N Coleman, HM Nguyen, Z Cao, BM Brown, DP Jenkins, D Zolkowska, ... Neurotherapeutics 12 (1), 234-249, 2015 | 47 | 2015 |
| Molecular basis of isoform-specific μ-conotoxin block of cardiac, skeletal muscle, and brain Na+ channels RA Li, IL Ennis, T Xue, HM Nguyen, GF Tomaselli, AL Goldin, E Marbán Journal of Biological Chemistry 278 (10), 8717-8724, 2003 | 47 | 2003 |
| Unique molecular characteristics and microglial origin of Kv1. 3 channel–positive brain myeloid cells in Alzheimer’s disease S Ramesha, S Rayaprolu, CA Bowen, CR Giver, S Bitarafan, HM Nguyen, ... Proceedings of the National Academy of Sciences 118 (11), e2013545118, 2021 | 37 | 2021 |
| Intracellular trafficking of the KV1. 3 potassium channel is regulated by the prodomain of a matrix metalloprotease HM Nguyen, CA Galea, G Schmunk, BJ Smith, RA Edwards, RS Norton, ... Journal of Biological Chemistry 288 (9), 6451-6464, 2013 | 30 | 2013 |