| Molecular mechanisms of protein aggregation from global fitting of kinetic models G Meisl, JB Kirkegaard, P Arosio, TCT Michaels, M Vendruscolo, ... Nature protocols 11 (2), 252-272, 2016 | 747 | 2016 |
| Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation C Galvagnion, AK Buell, G Meisl, TCT Michaels, M Vendruscolo, ... Nature chemical biology 11 (3), 229-234, 2015 | 720 | 2015 |
| Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides G Meisl, X Yang, E Hellstrand, B Frohm, JB Kirkegaard, SIA Cohen, ... Proceedings of the National Academy of Sciences 111 (26), 9384-9389, 2014 | 549 | 2014 |
| Secondary nucleation in amyloid formation M Törnquist, TCT Michaels, K Sanagavarapu, X Yang, G Meisl, ... Chemical communications 54 (63), 8667-8684, 2018 | 442 | 2018 |
| Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of α-synuclein aggregation P Flagmeier, G Meisl, M Vendruscolo, TPJ Knowles, CM Dobson, ... Proceedings of the National Academy of Sciences 113 (37), 10328-10333, 2016 | 349 | 2016 |
| A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, ... Proceedings of the National Academy of Sciences 114 (6), E1009-E1017, 2017 | 335 | 2017 |
| Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide TCT Michaels, A Šarić, S Curk, K Bernfur, P Arosio, G Meisl, AJ Dear, ... Nature chemistry 12 (5), 445-451, 2020 | 313 | 2020 |
| α-Synuclein strains target distinct brain regions and cell types A Lau, RWL So, HHC Lau, JC Sang, A Ruiz-Riquelme, SC Fleck, E Stuart, ... Nature neuroscience 23 (1), 21-31, 2020 | 277 | 2020 |
| Secondary nucleation of monomers on fibril surface dominates α-synuclein aggregation and provides autocatalytic amyloid amplification R Gaspar, G Meisl, AK Buell, L Young, CF Kaminski, TPJ Knowles, ... Quarterly reviews of biophysics 50, e6, 2017 | 250 | 2017 |
| Ostwald’s rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers A Levin, TO Mason, L Adler-Abramovich, AK Buell, G Meisl, C Galvagnion, ... Nature communications 5 (1), 5219, 2014 | 239 | 2014 |
| Chemical kinetics for bridging molecular mechanisms and macroscopic measurements of amyloid fibril formation TCT Michaels, A Šarić, J Habchi, S Chia, G Meisl, M Vendruscolo, ... Annual review of physical chemistry 69 (1), 273-298, 2018 | 217 | 2018 |
| Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies S Linse, T Scheidt, K Bernfur, M Vendruscolo, CM Dobson, SIA Cohen, ... Nature structural & molecular biology 27 (12), 1125-1133, 2020 | 180 | 2020 |
| Kinetic diversity of amyloid oligomers AJ Dear, TCT Michaels, G Meisl, D Klenerman, S Wu, S Perrett, S Linse, ... Proceedings of the National Academy of Sciences 117 (22), 12087-12094, 2020 | 169 | 2020 |
| The Aβ40 and Aβ42 peptides self-assemble into separate homomolecular fibrils in binary mixtures but cross-react during primary nucleation R Cukalevski, X Yang, G Meisl, U Weininger, K Bernfur, B Frohm, ... Chemical science 6 (7), 4215-4233, 2015 | 163 | 2015 |
| Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, ... Nature communications 10 (1), 225, 2019 | 153 | 2019 |
| On the role of sidechain size and charge in the aggregation of Aβ42 with familial mutations X Yang, G Meisl, B Frohm, E Thulin, TPJ Knowles, S Linse Proceedings of the National Academy of Sciences 115 (26), E5849-E5858, 2018 | 125 | 2018 |
| Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine M Perni, P Flagmeier, R Limbocker, R Cascella, FA Aprile, C Galvagnion, ... ACS chemical biology 13 (8), 2308-2319, 2018 | 120 | 2018 |
| Quantitative analysis of intrinsic and extrinsic factors in the aggregation mechanism of Alzheimer-associated Aβ-peptide G Meisl, X Yang, B Frohm, TPJ Knowles, S Linse Scientific reports 6 (1), 18728, 2016 | 111 | 2016 |
| In vivo rate-determining steps of tau seed accumulation in Alzheimer’s disease G Meisl, E Hidari, K Allinson, T Rittman, SL DeVos, JS Sanchez, CK Xu, ... Science advances 7 (44), eabh1448, 2021 | 109 | 2021 |
| Origin of metastable oligomers and their effects on amyloid fibril self-assembly F Hasecke, T Miti, C Perez, J Barton, D Schölzel, L Gremer, CSR Grüning, ... Chemical science 9 (27), 5937-5948, 2018 | 109 | 2018 |
Tuomas KnowlesProfessor of Physical Chemistry and Biophysics, University of Cambridgecam.ac.uk의 이메일 확인됨