| Recombinant immunoglobin preparations S Cabilly, HL Heyneker, WE Holmes, AD Riggs, RB Wetzel US Patent 4,816,567, 1989 | 7040 | 1989 |
| Huntington disease GP Bates, R Dorsey, JF Gusella, MR Hayden, C Kay, BR Leavitt, M Nance, ... Nature Reviews Disease Primers, 2015 | 1703 | 2015 |
| Huntington Disease GP BATES, R DORSEY, JF GUSELLA, MR HAYDEN, C KAY, ... Nature Reviews Disease Primers, article number 15005. doi: 10.1038/ nrdp, 2015 | 1703 | 2015 |
| Methods of producing immunoglobulins, vectors and transformed host cells for use therein S Cabilly, HL Heyneker, WE Holmes, AD Riggs, RB Wetzel US Patent 6,331,415, 2001 | 838 | 2001 |
| Huntington's disease age-of-onset linked to polyglutamine aggregation nucleation S Chen, FA Ferrone, R Wetzel Proceedings of the National Academy of sciences 99 (18), 11884-11889, 2002 | 677 | 2002 |
| Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins P Venkatraman, R Wetzel, M Tanaka, N Nukina, AL Goldberg Molecular cell 14 (1), 95-104, 2004 | 530 | 2004 |
| Disulfide bond engineered into T4 lysozyme: stabilization of the protein toward thermal inactivation LJ Perry, R Wetzel Science 226 (4674), 555-557, 1984 | 505 | 1984 |
| Seeding specificity in amyloid growth induced by heterologous fibrils B O'Nuallain, AD Williams, P Westermark, R Wetzel Journal of Biological Chemistry 279 (17), 17490-17499, 2004 | 502 | 2004 |
| Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism AK Thakur, M Jayaraman, R Mishra, M Thakur, VM Chellgren, IJ L Byeon, ... Nature structural & molecular biology 16 (4), 380-389, 2009 | 490 | 2009 |
| Mapping Aβ amyloid fibril secondary structure using scanning proline mutagenesis AD Williams, E Portelius, I Kheterpal, J Guo, KD Cook, Y Xu, R Wetzel Journal of molecular biology 335 (3), 833-842, 2004 | 479 | 2004 |
| Aggregated polyglutamine peptides delivered to nuclei are toxic to mammalian cells W Yang, JR Dunlap, RB Andrews, R Wetzel Human molecular genetics 11 (23), 2905-2917, 2002 | 473 | 2002 |
| Physical, morphological and functional differences between pH 5.8 and 7.4 aggregates of the Alzheimer's amyloid peptide A β SJ Wood, B Maleeff, T Hart, R Wetzel Journal of molecular biology 256 (5), 870-877, 1996 | 464 | 1996 |
| Polymorphism in the intermediates and products of amyloid assembly R Kodali, R Wetzel Current opinion in structural biology 17 (1), 48-57, 2007 | 453 | 2007 |
| Conformational Abs recognizing a generic amyloid fibril epitope B O'Nuallain, R Wetzel Proceedings of the National Academy of Sciences 99 (3), 1485-1490, 2002 | 451 | 2002 |
| Prolines and Amyloidogenicity in Fragments of the Alzheimer's Peptide. beta./A4 SJ Wood, R Wetzel, JD Martin, MR Hurle Biochemistry 34 (3), 724-730, 1995 | 448 | 1995 |
| A role for destabilizing amino acid replacements in light-chain amyloidosis. MR Hurle, LR Helms, LIN Li, W Chan, R Wetzel Proceedings of the National Academy of Sciences 91 (12), 5446-5450, 1994 | 428 | 1994 |
| Amyloid-like features of polyglutamine aggregates and their assembly kinetics S Chen, V Berthelier, JB Hamilton, B O'Nuallai, R Wetzel Biochemistry 41 (23), 7391-7399, 2002 | 427 | 2002 |
| Polyglutamine aggregation behavior in vitro supports a recruitment mechanism of cytotoxicity S Chen, V Berthelier, W Yang, R Wetzel Journal of molecular biology 311 (1), 173-182, 2001 | 409 | 2001 |
| Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions EJ Slow, RK Graham, AP Osmand, RS Devon, G Lu, Y Deng, J Pearson, ... Proceedings of the National Academy of Sciences 102 (32), 11402-11407, 2005 | 385 | 2005 |
| Generation of antibody activity from immunoglobulin polypeptide chains produced in Escherichia coli. S Cabilly, AD Riggs, H Pande, JE Shively, WE Holmes, M Rey, LJ Perry, ... Proceedings of the National Academy of Sciences 81 (11), 3273-3277, 1984 | 382 | 1984 |
Patrick van der WelUniversity of Groningen, Zernike Institute for Advanced Materialsrug.nl의 이메일 확인됨