| Functional correction of CNS lesions in an MPS-IIIA mouse model by intracerebral AAV-mediated delivery of sulfamidase and SUMF1 genes A Fraldi, K Hemsley, A Crawley, A Lombardi, A Lau, L Sutherland, ... Human molecular genetics 16 (22), 2693-2702, 2007 | 166 | 2007 |
| Endo‐lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease? LS Whyte, AA Lau, KM Hemsley, JJ Hopwood, TJ Sargeant Journal of neurochemistry 140 (5), 703-717, 2017 | 163 | 2017 |
| Open field locomotor activity and anxiety-related behaviors in mucopolysaccharidosis type IIIA mice AA Lau, AC Crawley, JJ Hopwood, KM Hemsley Behavioural brain research 191 (1), 130-136, 2008 | 92 | 2008 |
| Reduction in open field activity in the absence of memory deficits in the AppNL− G− F knock-in mouse model of Alzheimer’s disease LS Whyte, KM Hemsley, AA Lau, S Hassiotis, T Saito, TC Saido, ... Behavioural brain research 336, 177-181, 2018 | 84 | 2018 |
| A low omega-6 polyunsaturated fatty acid (n-6 PUFA) diet increases omega-3 (n-3) long chain PUFA status in plasma phospholipids in humans KE Wood, A Lau, E Mantzioris, RA Gibson, CE Ramsden, BS Muhlhausler Prostaglandins, Leukotrienes and Essential Fatty Acids 90 (4), 133-138, 2014 | 57 | 2014 |
| A preclinical study evaluating AAVrh10-based gene therapy for Sanfilippo syndrome LK Winner, H Beard, S Hassiotis, AA Lau, AJ Luck, JJ Hopwood, ... Human gene therapy 27 (5), 363-375, 2016 | 53 | 2016 |
| Allogeneic stem cell transplantation does not improve neurological deficits in mucopolysaccharidosis type IIIA mice AA Lau, H Hannouche, T Rozaklis, S Hassiotis, JJ Hopwood, ... Experimental neurology 225 (2), 445-454, 2010 | 42 | 2010 |
| SGSH gene transfer in mucopolysaccharidosis type IIIA mice using canine adenovirus vectors AA Lau, JJ Hopwood, EJ Kremer, KM Hemsley Molecular genetics and metabolism 100 (2), 168-175, 2010 | 33 | 2010 |
| A simple method for early age phenotype confirmation using toe tissue from a mouse model of MPS IIIA PJ Trim, AA Lau, JJ Hopwood, MF Snel Rapid Communications in Mass Spectrometry 28 (8), 933-938, 2014 | 32 | 2014 |
| AAVrh10 vector corrects disease pathology in MPS IIIA mice and achieves widespread distribution of SGSH in large animal brains M Hocquemiller, KM Hemsley, ML Douglass, SJ Tamang, D Neumann, ... Molecular Therapy Methods & Clinical Development 17, 174-187, 2020 | 30 | 2020 |
| Neonatal bone marrow transplantation in MPS IIIA mice AA Lau, NJ Shamsani, LK Winner, S Hassiotis, BM King, JJ Hopwood, ... JIMD Reports-Case and Research Reports, 2012/5, 121-132, 2013 | 27 | 2013 |
| Helper-dependent canine adenovirus vector-mediated transgene expression in a neurodegenerative lysosomal storage disorder AA Lau, T Rozaklis, S Ibanes, AJ Luck, H Beard, S Hassiotis, K Mazouni, ... Gene 491 (1), 53-57, 2012 | 25 | 2012 |
| A novel conditional Sgsh knockout mouse model recapitulates phenotypic and neuropathic deficits of Sanfilippo syndrome AA Lau, BM King, CL Thorsen, S Hassiotis, H Beard, PJ Trim, LS Whyte, ... Journal of Inherited Metabolic Disease 40, 715-724, 2017 | 17 | 2017 |
| Synthetic disaccharide standards enable quantitative analysis of stored heparan sulfate in MPS IIIA murine brain regions QQ He, PJ Trim, AA Lau, BM King, JJ Hopwood, KM Hemsley, MF Snel, ... ACS Chemical Neuroscience 10 (8), 3847-3858, 2019 | 15 | 2019 |
| Lysosomal dysregulation in the murine AppNL-GF/NL-GF model of Alzheimer’s disease LS Whyte, S Hassiotis, KJ Hattersley, KM Hemsley, JJ Hopwood, AA Lau, ... Neuroscience 429, 143-155, 2020 | 14 | 2020 |
| MPS-IIIA mice acquire autistic behaviours with age AA Lau, SJ Tamang, KM Hemsley Journal of Inherited Metabolic Disease 41 (4), 669-677, 2018 | 14 | 2018 |
| Lysosomal gene Hexb displays haploinsufficiency in a knock-in mouse model of Alzheimer’s disease LS Whyte, C Fourrier, S Hassiotis, AA Lau, PJ Trim, LK Hein, ... IBRO neuroscience reports 12, 131-141, 2022 | 11 | 2022 |
| Adeno-associated viral gene therapy for mucopolysaccharidoses exhibiting neurodegeneration AA Lau, KM Hemsley Journal of Molecular Medicine 95 (10), 1043-1052, 2017 | 10 | 2017 |
| In vitro characterization of genetically modified embryonic stem cells as a therapy for murine mucopolysaccharidosis type IIIA AA Lau, KM Hemsley, A Meedeniya, JJ Hopwood Molecular genetics and metabolism 81 (2), 86-95, 2004 | 10 | 2004 |
| Variables influencing fluorimetric N-sulfoglucosamine sulfohydrolase (SGSH) activity measurement in brain homogenates LS Whyte, JJ Hopwood, KM Hemsley, AA Lau Molecular Genetics and Metabolism Reports 5, 60-62, 2015 | 7 | 2015 |
