Pervasive functional translation of noncanonical human open reading frames J Chen, AD Brunner, JZ Cogan, JK Nuñez, AP Fields, B Adamson, ... Science 367 (6482), 1140-1146, 2020 | 552 | 2020 |
Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing JK Nuñez, J Chen, GC Pommier, JZ Cogan, JM Replogle, C Adriaens, ... Cell 184 (9), 2503-2519. e17, 2021 | 522 | 2021 |
Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing JM Replogle, TM Norman, A Xu, JA Hussmann, J Chen, JZ Cogan, ... Nature biotechnology 38 (8), 954-961, 2020 | 343 | 2020 |
N6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics J Choi, KW Ieong, H Demirci, J Chen, A Petrov, A Prabhakar, SE O'leary, ... Nature structural & molecular biology 23 (2), 110-115, 2016 | 246 | 2016 |
Structured elements drive extensive circular RNA translation CK Chen, R Cheng, J Demeter, J Chen, S Weingarten-Gabbay, L Jiang, ... Molecular cell 81 (20), 4300-4318. e13, 2021 | 202 | 2021 |
Dynamic pathways of− 1 translational frameshifting J Chen, A Petrov, M Johansson, A Tsai, SE O’leary, JD Puglisi Nature 512 (7514), 328-332, 2014 | 187 | 2014 |
Standardized annotation of translated open reading frames JM Mudge, J Ruiz-Orera, JR Prensner, MA Brunet, F Calvet, I Jungreis, ... Nature biotechnology 40 (7), 994-999, 2022 | 165 | 2022 |
Coordinated conformational and compositional dynamics drive ribosome translocation J Chen, A Petrov, AT Seán, E O'Leary, JD Puglisi Biophysical Journal 104 (2), 260a, 2013 | 151 | 2013 |
High-throughput platform for real-time monitoring of biological processes by multicolor single-molecule fluorescence J Chen, RV Dalal, AN Petrov, A Tsai, SE O’Leary, K Chapin, J Cheng, ... Proceedings of the National Academy of Sciences 111 (2), 664-669, 2014 | 145 | 2014 |
A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation YH Lo, KS Kolahi, Y Du, CY Chang, A Krokhotin, A Nair, WD Sobba, ... Cancer discovery 11 (6), 1562-1581, 2021 | 128 | 2021 |
The dark proteome: translation from noncanonical open reading frames BW Wright, Z Yi, JS Weissman, J Chen Trends in Cell Biology 32 (3), 243-258, 2022 | 118 | 2022 |
Unraveling the dynamics of ribosome translocation J Chen, A Tsai, SE O’Leary, A Petrov, JD Puglisi Current opinion in structural biology 22 (6), 804-814, 2012 | 94 | 2012 |
Multiple parallel pathways of translation initiation on the CrPV IRES A Petrov, R Grosely, J Chen, SE O’Leary, JD Puglisi Molecular cell 62 (1), 92-103, 2016 | 80 | 2016 |
Noise of Silicon Nanowire BioFETs NK Rajan, DA Routenberg, J Chen, MA Reed IEEE Electron Device Letters 31 (6), 615-617, 2010 | 76 | 2010 |
The dynamics of SecM-induced translational stalling A Tsai, G Kornberg, M Johansson, J Chen, JD Puglisi Cell reports 7 (5), 1521-1533, 2014 | 63 | 2014 |
Developmental dynamics of RNA translation in the human brain EE Duffy, B Finander, GH Choi, AC Carter, I Pritisanac, A Alam, V Luria, ... Nature neuroscience 25 (10), 1353-1365, 2022 | 61 | 2022 |
Kinetic pathway of 40S ribosomal subunit recruitment to hepatitis C virus internal ribosome entry site G Fuchs, AN Petrov, CD Marceau, LM Popov, J Chen, SE O’Leary, ... Proceedings of the National Academy of Sciences 112 (2), 319-325, 2015 | 59 | 2015 |
Coupling of mRNA structure rearrangement to ribosome movement during bypassing of non-coding regions J Chen, A Coakley, M O’Connor, A Petrov, SE O’Leary, JF Atkins, ... Cell 163 (5), 1267-1280, 2015 | 53 | 2015 |
Dynamic recognition of the mRNA cap by Saccharomyces cerevisiae eIF4E SE O’Leary, A Petrov, J Chen, JD Puglisi Structure 21 (12), 2197-2207, 2013 | 53 | 2013 |
Nonfluorescent quenchers to correlate single-molecule conformational and compositional dynamics J Chen, A Tsai, A Petrov, JD Puglisi Journal of the American Chemical Society 134 (13), 5734-5737, 2012 | 50 | 2012 |