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Lorena Zuliani Alvarez
Lorena Zuliani Alvarez
Principal Scientist, NIBR
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Evolution of enhanced innate immune evasion by SARS-CoV-2
LG Thorne, M Bouhaddou, AK Reuschl, L Zuliani-Alvarez, B Polacco, ...
Nature 602 (7897), 487-495, 2022
3462022
SARS‐CoV‐2 sensing by RIG‐I and MDA5 links epithelial infection to macrophage inflammation
LG Thorne, AK Reuschl, L Zuliani‐Alvarez, MVX Whelan, J Turner, ...
The EMBO journal 40 (15), e107826, 2021
2162021
Mutations in SARS-CoV-2 variants of concern link to increased spike cleavage and virus transmission
A Escalera, AS Gonzalez-Reiche, S Aslam, I Mena, M Laporte, RL Pearl, ...
Cell host & microbe 30 (3), 373-387. e7, 2022
1712022
Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers
L Zuliani-Alvarez, AM Marzeda, C Deligne, A Schwenzer, FE McCann, ...
Nature communications 8 (1), 1595, 2017
1052017
Evolution of enhanced innate immune evasion by the SARS-CoV-2 B. 1.1. 7 UK variant
LG Thorne, M Bouhaddou, AK Reuschl, L Zuliani-Alvarez, B Polacco, ...
BioRxiv, 2021
932021
CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes
M Gupta, CM Azumaya, M Moritz, S Pourmal, A Diallo, GE Merz, G Jang, ...
Research square, rs. 3. rs-515215, 2021
882021
Distinct microenvironmental cues stimulate divergent TLR4-mediated signaling pathways in macrophages
AM Piccinini, L Zuliani-Alvarez, JMP Lim, KS Midwood
Science signaling 9 (443), ra86-ra86, 2016
882016
Disrupting HIV‐1 capsid formation causes cGAS sensing of viral DNA
RP Sumner, L Harrison, E Touizer, TP Peacock, M Spencer, ...
The EMBO journal 39 (20), e103958, 2020
732020
Fibrinogen-related proteins in tissue repair: how a unique domain with a common structure controls diverse aspects of wound healing
L Zuliani-Alvarez, KS Midwood
Advances in wound care 4 (5), 273-285, 2015
662015
SARS-CoV-2 variants evolve convergent strategies to remodel the host response
M Bouhaddou, AK Reuschl, BJ Polacco, LG Thorne, MR Ummadi, C Ye, ...
Cell 186 (21), 4597-4614. e26, 2023
612023
Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis
T Kehrer, A Cupic, C Ye, S Yildiz, M Bouhaddou, NA Crossland, ...
Cell host & microbe 31 (10), 1668-1684. e12, 2023
612023
HIV-1 Vpr antagonizes innate immune activation by targeting karyopherin-mediated NF-κB/IRF3 nuclear transport
H Khan, RP Sumner, J Rasaiyaah, CP Tan, MT Rodriguez-Plata, ...
Elife 9, e60821, 2020
482020
TLR4-mediated pathway triggers interferon-independent G0 arrest and antiviral SAMHD1 activity in macrophages
P Mlcochova, H Winstone, L Zuliani-Alvarez, RK Gupta
Cell reports 30 (12), 3972-3980. e5, 2020
432020
Evasion of cGAS and TRIM5 defines pandemic HIV
L Zuliani-Alvarez, ML Govasli, J Rasaiyaah, C Monit, SO Perry, ...
Nature microbiology 7 (11), 1762-1776, 2022
412022
Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4
A Maqbool, EJ Spary, IW Manfield, M Ruhmann, L Zuliani-Alvarez, ...
World journal of cardiology 8 (5), 340, 2016
402016
Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19
JF Varona, P Landete, JA Lopez-Martin, V Estrada, R Paredes, ...
Life science alliance 5 (4), 2022
382022
Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B. 1.1. 7 variant
AK Reuschl, LG Thorne, L Zuliani-Alvarez, M Bouhaddou, K Obernier, ...
BioRxiv, 2021
372021
Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets
KM Haas, MJ McGregor, M Bouhaddou, BJ Polacco, EY Kim, TT Nguyen, ...
Nature communications 14 (1), 6030, 2023
202023
SARS-CoV-2 variants of concern have acquired mutations associated with an increased spike cleavage
A Escalera, AS Gonzalez-Reiche, S Aslam, I Mena, RL Pearl, M Laporte, ...
bioRxiv, 2021.08. 05.455290, 2021
202021
Global landscape of the host response to SARS-CoV-2 variants reveals viral evolutionary trajectories
M Bouhaddou, AK Reuschl, BJ Polacco, LG Thorne, MR Ummadi, C Ye, ...
bioRxiv, 2022.10. 19.512927, 2022
142022
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