| De novo design of picomolar SARS-CoV-2 miniprotein inhibitors L Cao, I Goreshnik, B Coventry, JB Case, L Miller, L Kozodoy, RE Chen, ... Science 370 (6515), 426-431, 2020 | 672 | 2020 |
| Design of protein-binding proteins from the target structure alone L Cao, B Coventry, I Goreshnik, B Huang, W Sheffler, JS Park, KM Jude, ... Nature 605 (7910), 551-560, 2022 | 372 | 2022 |
| De novo design of luciferases using deep learning AHW Yeh, C Norn, Y Kipnis, D Tischer, SJ Pellock, D Evans, P Ma, ... Nature 614 (7949), 774-780, 2023 | 273 | 2023 |
| De novo design of modular and tunable protein biosensors A Quijano-Rubio, HW Yeh, J Park, H Lee, RA Langan, SE Boyken, ... Nature 591 (7850), 482-487, 2021 | 215 | 2021 |
| Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice AC Hunt, JB Case, YJ Park, L Cao, K Wu, AC Walls, Z Liu, JE Bowen, ... Science translational medicine 14 (646), eabn1252, 2022 | 100 | 2022 |
| Top-down design of protein architectures with reinforcement learning ID Lutz, S Wang, C Norn, A Courbet, AJ Borst, YT Zhao, A Dosey, L Cao, ... Science 380 (6642), 266-273, 2023 | 79 | 2023 |
| pH-dependent recognition of apoptotic and necrotic cells by the human dendritic cell receptor DEC205 L Cao, X Shi, H Chang, Q Zhang, Y He Proceedings of the National Academy of Sciences 112 (23), 7237-7242, 2015 | 57 | 2015 |
| Ultrapotent miniproteins targeting the SARS-CoV-2 receptor-binding domain protect against infection and disease JB Case, RE Chen, L Cao, B Ying, ES Winkler, M Johnson, I Goreshnik, ... Cell host & microbe 29 (7), 1151-1161. e5, 2021 | 55 | 2021 |
| Keratin mediates the recognition of apoptotic and necrotic cells through dendritic cell receptor DEC205/CD205 L Cao, H Chang, X Shi, C Peng, Y He Proceedings of the National Academy of Sciences 113 (47), 13438-13443, 2016 | 48 | 2016 |
| Structure of human M-type phospholipase A2 receptor revealed by cryo-electron microscopy Y Dong, L Cao, H Tang, X Shi, Y He Journal of molecular biology 429 (24), 3825-3835, 2017 | 40 | 2017 |
| Large-scale design and refinement of stable proteins using sequence-only models JM Singer, S Novotney, D Strickland, HK Haddox, N Leiby, GJ Rocklin, ... PloS one 17 (3), e0265020, 2022 | 31 | 2022 |
| Functional expression and characterization of the envelope glycoprotein E1E2 heterodimer of hepatitis C virus L Cao, B Yu, D Kong, Q Cong, T Yu, Z Chen, Z Hu, H Chang, J Zhong, ... PLoS pathogens 15 (5), e1007759, 2019 | 31 | 2019 |
| The scavenger receptor SCARA1 (CD204) recognizes dead cells through spectrin C Cheng, Z Hu, L Cao, C Peng, Y He Journal of Biological Chemistry 294 (49), 18881-18897, 2019 | 21 | 2019 |
| Multivalent designed proteins protect against SARS-CoV-2 variants of concern AC Hunt, JB Case, YJ Park, L Cao, K Wu, AC Walls, Z Liu, JE Bowen, ... BioRxiv, 2021 | 19 | 2021 |
| Cbln1 and Cbln4 are structurally similar but differ in GluD2 binding interactions C Zhong, J Shen, H Zhang, G Li, S Shen, F Wang, K Hu, L Cao, Y He, ... Cell reports 20 (10), 2328-2340, 2017 | 17 | 2017 |
| SARS-COV-2 spike binding to ACE2 in living cells monitored by TR-FRET E Cecon, M Burridge, L Cao, L Carter, R Ravichandran, J Dam, R Jockers Cell Chemical Biology 29 (1), 74-83. e4, 2022 | 15 | 2022 |
| Robust de novo design of protein binding proteins from target structural information alone L Cao, B Coventry, I Goreshnik, B Huang, JS Park, KM Jude, I Marković, ... BioRxiv, 2021.09. 04.459002, 2021 | 15 | 2021 |
| Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies NI Edman, A Phal, RL Redler, T Schlichthaerle, SR Srivatsan, DD Ehnes, ... Cell 187 (14), 3726-3740. e43, 2024 | 14 | 2024 |
| The JAK-STAT pathway: from structural biology to cytokine engineering Y Lv, J Qi, JJ Babon, L Cao, G Fan, J Lang, J Zhang, P Mi, B Kobe, ... Signal Transduction and Targeted Therapy 9 (1), 221, 2024 | 11 | 2024 |
| Small molecule drug discovery targeting the JAK-STAT pathway Y Lv, P Mi, JJ Babon, G Fan, J Qi, L Cao, J Lang, J Zhang, F Wang, ... Pharmacological Research, 107217, 2024 | 10 | 2024 |
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