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José Pedro Castro
José Pedro Castro
Assistant Researcher, Harvard Medical School and I3S
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Happily (n) ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence
A Höhn, D Weber, T Jung, C Ott, M Hugo, B Kochlik, R Kehm, J König, ...
Redox biology 11, 482-501, 2017
4112017
Sarcopenia–Molecular mechanisms and open questions
P Wiedmer, T Jung, JP Castro, LCD Pomatto, PY Sun, KJA Davies, ...
Ageing research reviews 65, 101200, 2021
3522021
Proteostasis, oxidative stress and aging
I Korovila, M Hugo, JP Castro, D Weber, A Höhn, T Grune, T Jung
Redox biology 13, 550-567, 2017
2802017
4-Hydroxynonenal (HNE) modified proteins in metabolic diseases
JP Castro, T Jung, T Grune, W Siems
Free Radical Biology and Medicine 111, 309-315, 2017
2612017
COVID‐19 is an emergent disease of aging
D Santesmasses, JP Castro, AA Zenin, AV Shindyapina, ...
Aging cell 19 (10), e13230, 2020
2042020
The two faces of reactive oxygen species (ROS) in adipocyte function and dysfunction
JP Castro, T Grune, B Speckmann
Biological chemistry 397 (8), 709-724, 2016
1642016
The molecular chaperone Hsp70 promotes the proteolytic removal of oxidatively damaged proteins by the proteasome
S Reeg, T Jung, JP Castro, KJA Davies, A Henze, T Grune
Free Radical Biology and Medicine 99, 153-166, 2016
1262016
Impaired proteostasis during skeletal muscle aging
R Fernando, C Drescher, K Nowotny, T Grune, JP Castro
Free Radical Biology and Medicine 132, 58-66, 2019
1192019
Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna
AV Shindyapina, Y Cho, A Kaya, A Tyshkovskiy, JP Castro, A Deik, ...
Science advances 8 (37), eabo5482, 2022
692022
Carbonylation of the cytoskeletal protein actin leads to aggregate formation
JP Castro, C Ott, T Jung, T Grune, H Almeida
Free Radical Biology and Medicine 53 (4), 916-925, 2012
692012
Distinct longevity mechanisms across and within species and their association with aging
A Tyshkovskiy, S Ma, AV Shindyapina, S Tikhonov, SG Lee, P Bozaykut, ...
Cell 186 (13), 2929-2949. e20, 2023
642023
Induction of steatohepatitis (NASH) with insulin resistance in wild-type B6 mice by a western-type diet containing soybean oil and cholesterol
J Henkel, CD Coleman, A Schraplau, K Jöhrens, D Weber, JP Castro, ...
Molecular Medicine 23, 70-82, 2017
632017
Mitochondrial chaperones in the brain: safeguarding brain health and metabolism?
JP Castro, K Wardelmann, T Grune, A Kleinridders
Frontiers in endocrinology 9, 196, 2018
532018
Actin carbonylation: from cell dysfunction to organism disorder
JP Castro, T Jung, T Grune, H Almeida
Journal of proteomics 92, 171-180, 2013
452013
Soybean oil-derived poly-unsaturated fatty acids enhance liver damage in NAFLD induced by dietary cholesterol
J Henkel, E Alfine, J Saín, K Jöhrens, D Weber, JP Castro, J König, ...
Nutrients 10 (9), 1326, 2018
422018
In vivo cyclic induction of the FOXM1 transcription factor delays natural and progeroid aging phenotypes and extends healthspan
R Ribeiro, JC Macedo, M Costa, V Ustiyan, AV Shindyapina, ...
Nature aging 2 (5), 397-411, 2022
402022
Oxidants produced by methylglyoxal-modified collagen trigger ER stress and apoptosis in skin fibroblasts
K Nowotny, JP Castro, M Hugo, S Braune, D Weber, M Pignitter, ...
Free Radical Biology and Medicine 120, 102-113, 2018
372018
Low steady-state oxidative stress inhibits adipogenesis by altering mitochondrial dynamics and decreasing cellular respiration
R Fernando, K Wardelmann, S Deubel, R Kehm, T Jung, M Mariotti, ...
Redox Biology 32, 101507, 2020
262020
Age‐related maintenance of the autophagy‐lysosomal system is dependent on skeletal muscle type
R Fernando, JP Castro, T Flore, S Deubel, T Grune, C Ott
Oxidative Medicine and Cellular Longevity 2020 (1), 4908162, 2020
252020
Reduced oxidative stress and enhanced FGF21 formation in livers of endurance-exercised rats with diet-induced NASH
J Henkel, K Buchheim-Dieckow, JP Castro, T Laeger, K Wardelmann, ...
Nutrients 11 (11), 2709, 2019
242019
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학술자료 1–20