Happily (n) ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence A Höhn, D Weber, T Jung, C Ott, M Hugo, B Kochlik, R Kehm, J König, ... Redox biology 11, 482-501, 2017 | 411 | 2017 |
Sarcopenia–Molecular mechanisms and open questions P Wiedmer, T Jung, JP Castro, LCD Pomatto, PY Sun, KJA Davies, ... Ageing research reviews 65, 101200, 2021 | 352 | 2021 |
Proteostasis, oxidative stress and aging I Korovila, M Hugo, JP Castro, D Weber, A Höhn, T Grune, T Jung Redox biology 13, 550-567, 2017 | 280 | 2017 |
4-Hydroxynonenal (HNE) modified proteins in metabolic diseases JP Castro, T Jung, T Grune, W Siems Free Radical Biology and Medicine 111, 309-315, 2017 | 261 | 2017 |
COVID‐19 is an emergent disease of aging D Santesmasses, JP Castro, AA Zenin, AV Shindyapina, ... Aging cell 19 (10), e13230, 2020 | 204 | 2020 |
The two faces of reactive oxygen species (ROS) in adipocyte function and dysfunction JP Castro, T Grune, B Speckmann Biological chemistry 397 (8), 709-724, 2016 | 164 | 2016 |
The molecular chaperone Hsp70 promotes the proteolytic removal of oxidatively damaged proteins by the proteasome S Reeg, T Jung, JP Castro, KJA Davies, A Henze, T Grune Free Radical Biology and Medicine 99, 153-166, 2016 | 126 | 2016 |
Impaired proteostasis during skeletal muscle aging R Fernando, C Drescher, K Nowotny, T Grune, JP Castro Free Radical Biology and Medicine 132, 58-66, 2019 | 119 | 2019 |
Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna AV Shindyapina, Y Cho, A Kaya, A Tyshkovskiy, JP Castro, A Deik, ... Science advances 8 (37), eabo5482, 2022 | 69 | 2022 |
Carbonylation of the cytoskeletal protein actin leads to aggregate formation JP Castro, C Ott, T Jung, T Grune, H Almeida Free Radical Biology and Medicine 53 (4), 916-925, 2012 | 69 | 2012 |
Distinct longevity mechanisms across and within species and their association with aging A Tyshkovskiy, S Ma, AV Shindyapina, S Tikhonov, SG Lee, P Bozaykut, ... Cell 186 (13), 2929-2949. e20, 2023 | 64 | 2023 |
Induction of steatohepatitis (NASH) with insulin resistance in wild-type B6 mice by a western-type diet containing soybean oil and cholesterol J Henkel, CD Coleman, A Schraplau, K Jöhrens, D Weber, JP Castro, ... Molecular Medicine 23, 70-82, 2017 | 63 | 2017 |
Mitochondrial chaperones in the brain: safeguarding brain health and metabolism? JP Castro, K Wardelmann, T Grune, A Kleinridders Frontiers in endocrinology 9, 196, 2018 | 53 | 2018 |
Actin carbonylation: from cell dysfunction to organism disorder JP Castro, T Jung, T Grune, H Almeida Journal of proteomics 92, 171-180, 2013 | 45 | 2013 |
Soybean oil-derived poly-unsaturated fatty acids enhance liver damage in NAFLD induced by dietary cholesterol J Henkel, E Alfine, J Saín, K Jöhrens, D Weber, JP Castro, J König, ... Nutrients 10 (9), 1326, 2018 | 42 | 2018 |
In vivo cyclic induction of the FOXM1 transcription factor delays natural and progeroid aging phenotypes and extends healthspan R Ribeiro, JC Macedo, M Costa, V Ustiyan, AV Shindyapina, ... Nature aging 2 (5), 397-411, 2022 | 40 | 2022 |
Oxidants produced by methylglyoxal-modified collagen trigger ER stress and apoptosis in skin fibroblasts K Nowotny, JP Castro, M Hugo, S Braune, D Weber, M Pignitter, ... Free Radical Biology and Medicine 120, 102-113, 2018 | 37 | 2018 |
Low steady-state oxidative stress inhibits adipogenesis by altering mitochondrial dynamics and decreasing cellular respiration R Fernando, K Wardelmann, S Deubel, R Kehm, T Jung, M Mariotti, ... Redox Biology 32, 101507, 2020 | 26 | 2020 |
Age‐related maintenance of the autophagy‐lysosomal system is dependent on skeletal muscle type R Fernando, JP Castro, T Flore, S Deubel, T Grune, C Ott Oxidative Medicine and Cellular Longevity 2020 (1), 4908162, 2020 | 25 | 2020 |
Reduced oxidative stress and enhanced FGF21 formation in livers of endurance-exercised rats with diet-induced NASH J Henkel, K Buchheim-Dieckow, JP Castro, T Laeger, K Wardelmann, ... Nutrients 11 (11), 2709, 2019 | 24 | 2019 |