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Harvey W. Smith
Harvey W. Smith
Rosalind and Morris Goodman Cancer Institute, McGill University
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Regulation of cell signalling by uPAR
HW Smith, CJ Marshall
Nature reviews Molecular cell biology 11 (1), 23-36, 2010
11312010
Stimulation of the weak ATPase activity of human hsp90 by a client protein
SH McLaughlin, HW Smith, SE Jackson
Journal of molecular biology 315 (4), 787-798, 2002
3442002
uPAR promotes formation of the p130Cas–Crk complex to activate Rac through DOCK180
HW Smith, P Marra, CJ Marshall
The journal of cell biology 182 (4), 777-790, 2008
1382008
ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer
G Deblois, HW Smith, IS Tam, SP Gravel, M Caron, P Savage, DP Labbé, ...
Nature communications 7 (1), 12156, 2016
1272016
Targeting EZH2 reactivates a breast cancer subtype-specific anti-metastatic transcriptional program
A Hirukawa, HW Smith, D Zuo, CR Dufour, P Savage, N Bertos, ...
Nature communications 9 (1), 2547, 2018
902018
LPP is a Src substrate required for invadopodia formation and efficient breast cancer lung metastasis
E Ngan, K Stoletov, HW Smith, J Common, WJ Muller, JD Lewis, ...
Nature communications 8 (1), 15059, 2017
782017
KIBRA (WWC1) Is a metastasis suppressor gene affected by chromosome 5q loss in triple-negative breast cancer
JF Knight, VYC Sung, E Kuzmin, AL Couzens, DA de Verteuil, ...
Cell reports 22 (12), 3191-3205, 2018
582018
Mammary epithelial-specific disruption of c-Src impairs cell cycle progression and tumorigenesis
R Marcotte, HW Smith, V Sanguin-Gendreau, RV McDonough, WJ Muller
Proceedings of the National Academy of Sciences 109 (8), 2808-2813, 2012
582012
Reduction of Global H3K27me3 Enhances HER2/ErbB2 Targeted Therapy
A Hirukawa, S Singh, J Wang, JP Rennhack, M Swiatnicki, ...
Cell reports 29 (2), 249-257. e8, 2019
402019
Inducible and coupled expression of the polyomavirus middle T antigen and Cre recombinase in transgenic mice: an in vivo model for synthetic viability in …
T Rao, JJ Ranger, HW Smith, SH Lam, L Chodosh, WJ Muller
Breast Cancer Research 16, 1-14, 2014
382014
An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis
HW Smith, A Hirukawa, V Sanguin-Gendreau, I Nandi, CR Dufour, D Zuo, ...
Nature Communications 10 (1), 2901, 2019
342019
Transgenic mouse models—A seminal breakthrough in oncogene research
HW Smith, WJ Muller
Cold Spring Harbor Protocols 2013 (12), pdb. top069765, 2013
302013
Coordinated activation of c-Src and FOXM1 drives tumor cell proliferation and breast cancer progression
I Nandi, HW Smith, V Sanguin-Gendreau, L Ji, A Pacis, V Papavasiliou, ...
The Journal of Clinical Investigation 133 (7), 2023
202023
An ErbB2 splice variant lacking exon 16 drives lung carcinoma
HW Smith, L Yang, C Ling, A Walsh, VD Martinez, J Boucher, D Zuo, ...
Proceedings of the National Academy of Sciences 117 (33), 20139-20148, 2020
182020
Elevated V–ATPase Activity Following PTEN Loss Is Required for Enhanced Oncogenic Signaling in Breast Cancer
AH Mohammad, SH Kim, N Bertos, W El-Assaad, I Nandi, H Smith, J Yang, ...
Molecular Cancer Research 18 (10), 1477-1490, 2020
142020
Integration of distinct ShcA signaling complexes promotes breast tumor growth and tyrosine kinase inhibitor resistance
JR Ha, R Ahn, HW Smith, V Sabourin, S Hébert, E Cepeda Cañedo, ...
Molecular Cancer Research 16 (5), 894-908, 2018
142018
Ezh2 promotes mammary tumor initiation through epigenetic regulation of the Wnt and mTORC1 signaling pathways
L Liu, B Xiao, A Hirukawa, HW Smith, D Zuo, V Sanguin-Gendreau, ...
Proceedings of the National Academy of Sciences 120 (33), e2303010120, 2023
82023
ARF6 controls RHOB targeting to endosomes regulating cancer cell invasion
K Zaoui, HW Smith, M Park, S Duhamel
Molecular & Cellular Oncology 7 (5), 1766932, 2020
32020
Abstract B007: c-Src and PRC2 activity in ErbB2-driven mammary tumorigenesis and acquired resistance to ErbB2-targeted therapy
HW Smith, A Hirukawa, V Sanguin-Gendreau, D Zuo, WJ Muller
Molecular Cancer Research 11 (10_Supplement), B007-B007, 2013
22013
Targeting fatty acid oxidation enhances response to HER2-targeted therapy
I Nandi, L Ji, HW Smith, D Avizonis, V Papavasiliou, C Lavoie, A Pacis, ...
Nature Communications 15 (1), 6587, 2024
12024
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