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Philip Van Damme
Philip Van Damme
Professor of Neuroscience, University of Leuven
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EFNS guidelines on the clinical management of amyotrophic lateral sclerosis (MALS)–revised report of an EFNS task force
EFNS Task Force on Diagnosis and Management of Amyotrophic Lateral Sclerosis:
European journal of neurology 19 (3), 360-375, 2012
11682012
Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility
International Multiple Sclerosis Genetics Consortium*†, ANZgene, ...
Science 365 (6460), eaav7188, 2019
10812019
Amyotrophic lateral sclerosis: a clinical review
P Masrori, P Van Damme
European journal of neurology 27 (10), 1918-1929, 2020
10042020
Safety and efficacy of eculizumab in anti-acetylcholine receptor antibody-positive refractory generalised myasthenia gravis (REGAIN): a phase 3, randomised, double-blind …
JF Howard, K Utsugisawa, M Benatar, H Murai, RJ Barohn, I Illa, S Jacob, ...
The Lancet Neurology 16 (12), 976-986, 2017
6842017
Genome-wide analyses identify KIF5A as a novel ALS gene
A Nicolas, KP Kenna, AE Renton, N Ticozzi, F Faghri, R Chia, ...
Neuron 97 (6), 1267-1288, 2018
6642018
Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis
W Van Rheenen, A Shatunov, AM Dekker, RL McLaughlin, FP Diekstra, ...
Nature genetics 48 (9), 1043-1048, 2016
6422016
Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS
E Storkebaum, D Lambrechts, M Dewerchin, MP Moreno-Murciano, ...
Nature neuroscience 8 (1), 85-92, 2005
6292005
The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis
L Van Den Bosch, P Van Damme, E Bogaert, W Robberecht
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1762 (11-12 …, 2006
6282006
Gain of toxicity from ALS/FTD-linked repeat expansions in C9ORF72 is alleviated by antisense oligonucleotides targeting GGGGCC-containing RNAs
J Jiang, Q Zhu, TF Gendron, S Saberi, M McAlonis-Downes, A Seelman, ...
Neuron 90 (3), 535-550, 2016
6142016
HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1–induced Charcot-Marie-Tooth disease
C d'Ydewalle, J Krishnan, DM Chiheb, P Van Damme, J Irobi, ...
Nature medicine 17 (8), 968-974, 2011
5842011
Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS
TM Miller, ME Cudkowicz, A Genge, PJ Shaw, G Sobue, RC Bucelli, ...
New England Journal of Medicine 387 (12), 1099-1110, 2022
5672022
Phase separation of C9orf72 dipeptide repeats perturbs stress granule dynamics
S Boeynaems, E Bogaert, D Kovacs, A Konijnenberg, E Timmerman, ...
Molecular cell 65 (6), 1044-1055. e5, 2017
5442017
Phase 1–2 Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS
T Miller, M Cudkowicz, PJ Shaw, PM Andersen, N Atassi, RC Bucelli, ...
New England Journal of Medicine 383 (2), 109-119, 2020
5412020
Prognosis for patients with amyotrophic lateral sclerosis: development and validation of a personalised prediction model
HJ Westeneng, TPA Debray, AE Visser, RPA van Eijk, JPK Rooney, ...
The Lancet Neurology 17 (5), 423-433, 2018
5092018
Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival
P Van Damme, A Van Hoecke, D Lambrechts, P Vanacker, E Bogaert, ...
The Journal of cell biology 181 (1), 37-41, 2008
4782008
Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
W Van Rheenen, RAA Van Der Spek, MK Bakker, JJFA Van Vugt, PJ Hop, ...
Nature genetics 53 (12), 1636-1648, 2021
3962021
HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients
W Guo, M Naujock, L Fumagalli, T Vandoorne, P Baatsen, R Boon, ...
Nature communications 8 (1), 861, 2017
3842017
EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans
A Van Hoecke, L Schoonaert, R Lemmens, M Timmers, KA Staats, ...
Nature medicine 18 (9), 1418-1422, 2012
3702012
Regional variation of Guillain-Barré syndrome
AY Doets, C Verboon, B Van Den Berg, T Harbo, DR Cornblath, ...
Brain 141 (10), 2866-2877, 2018
3502018
NEK1 variants confer susceptibility to amyotrophic lateral sclerosis
KP Kenna, PTC Van Doormaal, AM Dekker, N Ticozzi, BJ Kenna, ...
Nature genetics 48 (9), 1037-1042, 2016
3152016
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