| Antibody-drug conjugates: recent advances in conjugation and linker chemistries K Tsuchikama, Z An Protein & cell 9 (1), 33-46, 2018 | 742 | 2018 |
| Recent advances in enantioselective [2+ 2+ 2] cycloaddition T Shibata, K Tsuchikama Organic & Biomolecular Chemistry 6 (8), 1317-1323, 2008 | 282 | 2008 |
| Glutamic acid–valine–citrulline linkers ensure stability and efficacy of antibody–drug conjugates in mice Y Anami, CM Yamazaki, W Xiong, X Gui, N Zhang, Z An, K Tsuchikama Nature communications 9 (1), 2512, 2018 | 184 | 2018 |
| Antibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistance CM Yamazaki, A Yamaguchi, Y Anami, W Xiong, Y Otani, J Lee, NT Ueno, ... Nature communications 12 (1), 3528, 2021 | 182 | 2021 |
| Cationic iridium–BINAP complex-catalyzed addition of aryl ketones to alkynes and alkenes via directed C–H bond cleavage K Tsuchikama, M Kasagawa, YK Hashimoto, K Endo, T Shibata Journal of Organometallic Chemistry 693 (26), 3939-3942, 2008 | 173 | 2008 |
| Exploring the next generation of antibody–drug conjugates K Tsuchikama, Y Anami, SYY Ha, CM Yamazaki Nature Reviews Clinical Oncology 21 (3), 203-223, 2024 | 139 | 2024 |
| Cationic Ir(I)-Catalyzed sp3 C−H Bond Alkenylation of Amides with Alkynes K Tsuchikama, M Kasagawa, K Endo, T Shibata Organic Letters 11 (8), 1821-1823, 2009 | 130 | 2009 |
| Iridium‐Catalyzed Selective Synthesis of 4‐Substituted Benzofurans and Indoles via Directed Cyclodehydration K Tsuchikama, Y Hashimoto, K Endo, T Shibata Advanced Synthesis & Catalysis 351 (17), 2850-2854, 2009 | 104 | 2009 |
| Rh-Catalyzed Cyclization of Diynes and Enynes Initiated by Carbonyl-Directed Activation of Aromatic and Vinylic C− H Bonds K Tsuchikama, Y Kuwata, Y Tahara, Y Yoshinami, T Shibata Organic Letters 9 (16), 3097-3099, 2007 | 100 | 2007 |
| Enzymatic conjugation using branched linkers for constructing homogeneous antibody–drug conjugates with high potency Y Anami, W Xiong, X Gui, M Deng, CC Zhang, N Zhang, Z An, ... Organic & biomolecular chemistry 15 (26), 5635-5642, 2017 | 97 | 2017 |
| Enantioselective intramolecular [2+ 2+ 2] cycloaddition of triynes for the synthesis of atropisomeric chiral ortho-diarylbenzene derivatives T Shibata, K Tsuchikama, M Otsuka Tetrahedron: Asymmetry 17 (4), 614-619, 2006 | 95 | 2006 |
| Highly enantioselective synthesis of silahelicenes using Ir-catalyzed [2+ 2+ 2] cycloaddition T Shibata, T Uchiyama, Y Yoshinami, S Takayasu, K Tsuchikama, K Endo Chemical Communications 48 (9), 1311-1313, 2012 | 93 | 2012 |
| Highly enantioselective construction of a chiral spirocyclic structure by the [2+ 2+ 2] cycloaddition of diynes and exo-methylene cyclic compounds K Tsuchikama, Y Kuwata, T Shibata Journal of the American Chemical Society 128 (42), 13686-13687, 2006 | 93 | 2006 |
| Disrupting LILRB4/APOE interaction by an efficacious humanized antibody reverses T-cell suppression and blocks AML development X Gui, M Deng, H Song, Y Chen, J Xie, Z Li, L He, F Huang, Y Xu, ... Cancer immunology research 7 (8), 1244-1257, 2019 | 73 | 2019 |
| Iridium‐Catalyzed Enantioselective [2+ 2+ 2] Cycloaddition of Diynes and Monoalkynes for the Generation of Axial Chiralities T Shibata, Y Arai, K Takami, K Tsuchikama, T Fujimoto, S Takebayashi, ... Advanced Synthesis & Catalysis 348 (16‐17), 2475-2483, 2006 | 64 | 2006 |
| Rhodium-catalyzed enantioselective [2+ 2+ 2] cycloaddition of diynes with unfunctionalized alkenes T Shibata, A Kawachi, M Ogawa, Y Kuwata, K Tsuchikama, K Endo Tetrahedron 63 (52), 12853-12859, 2007 | 49 | 2007 |
| Modulating cocaine vaccine potency through hapten fluorination X Cai, K Tsuchikama, KD Janda Journal of the American Chemical Society 135 (8), 2971-2974, 2013 | 46 | 2013 |
| C4-alkoxy-HPD: A potent class of synthetic modulators surpassing nature in AI-2 quorum sensing K Tsuchikama, J Zhu, CA Lowery, GF Kaufmann, KD Janda Journal of the American Chemical Society 134 (33), 13562-13564, 2012 | 44 | 2012 |
| LILRB4-targeting antibody–drug conjugates for the treatment of acute myeloid leukemia Y Anami, M Deng, X Gui, A Yamaguchi, CM Yamazaki, N Zhang, ... Molecular cancer therapeutics 19 (11), 2330-2339, 2020 | 39 | 2020 |
| Homogeneity of antibody-drug conjugates critically impacts the therapeutic efficacy in brain tumors Y Anami, Y Otani, W Xiong, SYY Ha, A Yamaguchi, KA Rivera-Caraballo, ... Cell reports 39 (8), 2022 | 38 | 2022 |
