| Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy CC Liu, T Kanekiyo, H Xu, G Bu Nature Reviews Neurology 9 (2), 106-118, 2013 | 3976 | 2013 |
| ApoE and Aβ in Alzheimer’s disease: accidental encounters or partners? T Kanekiyo, H Xu, G Bu Neuron 81 (4), 740-754, 2014 | 712 | 2014 |
| Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance Z Zhao, AP Sagare, Q Ma, MR Halliday, P Kong, K Kisler, EA Winkler, ... Nature neuroscience 18 (7), 978-987, 2015 | 469 | 2015 |
| Blood-brain barrier dysfunction and the pathogenesis of Alzheimer’s disease Y Yamazaki, T Kanekiyo International journal of molecular sciences 18 (9), 1965, 2017 | 406 | 2017 |
| The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer’s disease T Kanekiyo, G Bu Frontiers in aging neuroscience 6, 93, 2014 | 314 | 2014 |
| Neuronal clearance of amyloid-β by endocytic receptor LRP1 T Kanekiyo, JR Cirrito, CC Liu, M Shinohara, J Li, DR Schuler, ... Journal of Neuroscience 33 (49), 19276-19283, 2013 | 306 | 2013 |
| APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease KL Youmans, LM Tai, E Nwabuisi-Heath, L Jungbauer, T Kanekiyo, ... Journal of Biological Chemistry 287 (50), 41774-41786, 2012 | 306 | 2012 |
| APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids J Zhao, Y Fu, Y Yamazaki, Y Ren, MD Davis, CC Liu, W Lu, X Wang, ... Nature communications 11 (1), 5540, 2020 | 276 | 2020 |
| Role of LRP1 in the pathogenesis of Alzheimer's disease: evidence from clinical and preclinical studies: Thematic Review Series: ApoE and Lipid Homeostasis in Alzheimer's Disease M Shinohara, M Tachibana, T Kanekiyo, G Bu Journal of lipid research 58 (7), 1267-1281, 2017 | 266 | 2017 |
| LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β T Kanekiyo, CC Liu, M Shinohara, J Li, G Bu Journal of Neuroscience 32 (46), 16458-16465, 2012 | 252 | 2012 |
| Astrocytic LRP1 mediates brain Aβ clearance and impacts amyloid deposition CC Liu, J Hu, N Zhao, J Wang, N Wang, JR Cirrito, T Kanekiyo, ... Journal of Neuroscience 37 (15), 4023-4031, 2017 | 247 | 2017 |
| Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-β uptake T Kanekiyo, J Zhang, Q Liu, CC Liu, L Zhang, G Bu Journal of Neuroscience 31 (5), 1644-1651, 2011 | 243 | 2011 |
| Vascular cell senescence contributes to blood–brain barrier breakdown Y Yamazaki, DJ Baker, M Tachibana, CC Liu, JM Van Deursen, TG Brott, ... Stroke 47 (4), 1068-1077, 2016 | 238 | 2016 |
| Differential regulation of amyloid-β endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms*♦ J Li, T Kanekiyo, M Shinohara, Y Zhang, MJ LaDu, H Xu, G Bu Journal of Biological Chemistry 287 (53), 44593-44601, 2012 | 229 | 2012 |
| APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes J Zhao, MD Davis, YA Martens, M Shinohara, NR Graff-Radford, ... Human molecular genetics 26 (14), 2690-2700, 2017 | 221 | 2017 |
| ApoE Cascade Hypothesis in the pathogenesis of Alzheimer’s disease and related dementias YA Martens, N Zhao, CC Liu, T Kanekiyo, AJ Yang, AM Goate, ... Neuron 110 (8), 1304-1317, 2022 | 214 | 2022 |
| Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer’s disease CC Liu, CW Tsai, F Deak, J Rogers, M Penuliar, YM Sung, JN Maher, ... Neuron 84 (1), 63-77, 2014 | 213 | 2014 |
| Alzheimer’s risk factors age, APOE genotype, and sex drive distinct molecular pathways N Zhao, Y Ren, Y Yamazaki, W Qiao, F Li, LM Felton, ... Neuron 106 (5), 727-742. e6, 2020 | 208 | 2020 |
| The role of APOE in cerebrovascular dysfunction LM Tai, R Thomas, FM Marottoli, KP Koster, T Kanekiyo, AWJ Morris, G Bu Acta neuropathologica 131, 709-723, 2016 | 205 | 2016 |
| Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody KL Youmans, LM Tai, T Kanekiyo, WB Stine Jr, SC Michon, ... Molecular neurodegeneration 7, 1-14, 2012 | 194 | 2012 |
