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Stephen D. Weeks
Stephen D. Weeks
Pledge Therapeutics
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SUMO fusions and SUMO-specific protease for efficient expression and purification of proteins
MP Malakhov, MR Mattern, OA Malakhova, M Drinker, SD Weeks, TR Butt
Journal of structural and functional genomics 5, 75-86, 2004
7502004
Ligation independent cloning vectors for expression of SUMO fusions
SD Weeks, M Drinker, PJ Loll
Protein expression and purification 53 (1), 40-50, 2007
1862007
Crystal structures of the Pyrococcus abyssi Sm core and its complex with RNA: common features of RNA binding in Archaea and Eukarya
S Thore, C Mayer, C Sauter, S Weeks, D Suck
Journal of Biological Chemistry 278 (2), 1239-1247, 2003
1382003
Structural basis for the interaction of a human small heat shock protein with the 14-3-3 universal signaling regulator
NN Sluchanko, S Beelen, AA Kulikova, SD Weeks, AA Antson, NB Gusev, ...
Structure 25 (2), 305-316, 2017
1352017
Three-dimensional structure of α-crystallin domain dimers of human small heat shock proteins HSPB1 and HSPB6
EV Baranova, SD Weeks, S Beelen, OV Bukach, NB Gusev, SV Strelkov
Journal of molecular biology 411 (1), 110-122, 2011
1352011
MALT1 auto-proteolysis is essential for NF-κB-dependent gene transcription in activated lymphocytes
M Baens, L Bonsignore, R Somers, C Vanderheydt, SD Weeks, ...
PloS one 9 (8), e103774, 2014
922014
Crystal structures of Lys‐63‐linked tri‐and di‐ubiquitin reveal a highly extended chain architecture
SD Weeks, KC Grasty, L Hernandez‐Cuebas, PJ Loll
Proteins: Structure, Function, and Bioinformatics 77 (4), 753-759, 2009
902009
Crag regulates epithelial architecture and polarized deposition of basement membrane proteins in Drosophila
N Denef, Y Chen, SD Weeks, G Barcelo, T Schüpbach
Developmental cell 14 (3), 354-364, 2008
882008
Molecular structure and dynamics of the dimeric human small heat shock protein HSPB6
SD Weeks, EV Baranova, M Heirbaut, S Beelen, AV Shkumatov, ...
Journal of structural biology 185 (3), 342-354, 2014
872014
Heptyl α‐D‐Mannosides Grafted on a β‐Cyclodextrin Core To Interfere with Escherichia coli Adhesion: An In Vivo Multivalent Effect
J Bouckaert, Z Li, C Xavier, M Almant, V Caveliers, T Lahoutte, SD Weeks, ...
Chemistry–A European Journal 19 (24), 7847-7855, 2013
832013
Crystal structure of a Josephin-ubiquitin complex: evolutionary restraints on ataxin-3 deubiquitinating activity
SD Weeks, KC Grasty, L Hernandez-Cuebas, PJ Loll
Journal of Biological Chemistry 286 (6), 4555-4565, 2011
642011
Aminoacyl-tRNA synthetases as valuable targets for antimicrobial drug discovery
L Pang, SD Weeks, A Van Aerschot
International Journal of Molecular Sciences 22 (4), 1750, 2021
622021
Characterization of mutants of human small heat shock protein HspB1 carrying replacements in the N-terminal domain and associated with hereditary motor neuron diseases
LK Muranova, SD Weeks, SV Strelkov, NB Gusev
PLoS One 10 (5), e0126248, 2015
512015
A carrier protein strategy yields the structure of dalbavancin
NJ Economou, V Nahoum, SD Weeks, KC Grasty, IJ Zentner, ...
Journal of the American Chemical Society 134 (10), 4637-4645, 2012
492012
The in-vitro effect of famotidine on sars-cov-2 proteases and virus replication
M Loffredo, H Lucero, DY Chen, A O’Connell, S Bergqvist, A Munawar, ...
Scientific reports 11 (1), 5433, 2021
472021
Characterization of human small heat shock protein HSPB1 α-crystallin domain localized mutants associated with hereditary motor neuron diseases
SD Weeks, LK Muranova, M Heirbaut, S Beelen, SV Strelkov, NB Gusev
Scientific Reports 8 (1), 688, 2018
462018
Characterization of oligosaccharides from the chondroitin sulfates: 1H‐NMR and 13C‐NMR studies of reduced disaccharides and tetrasaccharides
TN Huckerby, RM Lauder, GM Brown, IA Nieduszynski, K Anderson, ...
European Journal of Biochemistry 268 (5), 1181-1189, 2001
462001
Dissecting the functional role of the N-terminal domain of the human small heat shock protein HSPB6
M Heirbaut, S Beelen, SV Strelkov, SD Weeks
PLoS One 9 (8), e105892, 2014
422014
Expression, purification and preliminary biochemical and structural characterization of the leucine rich repeat namesake domain of leucine rich repeat kinase 2
R Vancraenenbroeck, E Lobbestael, SD Weeks, SV Strelkov, ...
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1824 (3), 450-460, 2012
392012
Specific sequences in the N-terminal domain of human small heat-shock protein HSPB6 dictate preferential hetero-oligomerization with the orthologue HSPB1
M Heirbaut, F Lermyte, EM Martin, S Beelen, F Sobott, SV Strelkov, ...
Journal of Biological Chemistry 292 (24), 9944-9957, 2017
352017
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