| The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism JM Murphy, PE Czabotar, JM Hildebrand, IS Lucet, JG Zhang, ... Immunity 39 (3), 443-453, 2013 | 1258 | 2013 |
| RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis JA Rickard, JA O’Donnell, JM Evans, N Lalaoui, AR Poh, TW Rogers, ... Cell 157 (5), 1175-1188, 2014 | 620 | 2014 |
| Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death JM Hildebrand, MC Tanzer, IS Lucet, SN Young, SK Spall, P Sharma, ... Proceedings of the National Academy of Sciences 111 (42), 15072-15077, 2014 | 605 | 2014 |
| Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner SA Conos, KW Chen, D De Nardo, H Hara, L Whitehead, G Núñez, ... Proceedings of the National Academy of Sciences 114 (6), E961-E969, 2017 | 452 | 2017 |
| The molecular basis of JAK/STAT inhibition by SOCS1 NPD Liau, A Laktyushin, IS Lucet, JM Murphy, S Yao, E Whitlock, ... Nature communications 9 (1), 1558, 2018 | 431 | 2018 |
| The molecular regulation of Janus kinase (JAK) activation JJ Babon, IS Lucet, JM Murphy, NA Nicola, LN Varghese Biochemical Journal 462 (1), 1-13, 2014 | 399 | 2014 |
| Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity JJ Babon, NJ Kershaw, JM Murphy, LN Varghese, A Laktyushin, ... Immunity 36 (2), 239-250, 2012 | 334 | 2012 |
| Necroptosis and ferroptosis are alternative cell death pathways that operate in acute kidney failure T Müller, C Dewitz, J Schmitz, AS Schröder, JH Bräsen, BR Stockwell, ... Cellular and Molecular Life Sciences 74, 3631-3645, 2017 | 332 | 2017 |
| SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition NJ Kershaw, JM Murphy, NPD Liau, LN Varghese, A Laktyushin, ... Nature structural & molecular biology 20 (4), 469-476, 2013 | 327 | 2013 |
| MK2 phosphorylates RIPK1 to prevent TNF-induced cell death I Jaco, A Annibaldi, N Lalaoui, R Wilson, T Tenev, L Laurien, C Kim, ... Molecular cell 66 (5), 698-710. e5, 2017 | 294 | 2017 |
| A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties JM Murphy, Q Zhang, SN Young, ML Reese, FP Bailey, PA Eyers, ... Biochemical Journal 457 (2), 323-334, 2014 | 291 | 2014 |
| MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis AL Samson, Y Zhang, ND Geoghegan, XJ Gavin, KA Davies, ... Nature communications 11 (1), 3151, 2020 | 281 | 2020 |
| Regulated necrosis in kidney ischemia-reperfusion injury A Pefanis, FL Ierino, JM Murphy, PJ Cowan Kidney international 96 (2), 291-301, 2019 | 277 | 2019 |
| TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice JA Rickard, H Anderton, N Etemadi, U Nachbur, M Darding, N Peltzer, ... Elife 3, e03464, 2014 | 270 | 2014 |
| Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax J Gruszczyk, U Kanjee, LJ Chan, S Menant, B Malleret, NTY Lim, ... Science 359 (6371), 48-55, 2018 | 208 | 2018 |
| Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis EJ Petrie, JJ Sandow, AV Jacobsen, BJ Smith, MDW Griffin, IS Lucet, ... Nature communications 9 (1), 2422, 2018 | 194 | 2018 |
| EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation JS Pearson, C Giogha, S Mühlen, U Nachbur, CLL Pham, Y Zhang, ... Nature microbiology 2 (4), 1-10, 2017 | 192 | 2017 |
| TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1 DM Moujalled, WD Cook, T Okamoto, J Murphy, KE Lawlor, JE Vince, ... Cell death & disease 4 (1), e465-e465, 2013 | 185 | 2013 |
| cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1-and RIPK3-dependent manner WWL Wong, JE Vince, N Lalaoui, KE Lawlor, D Chau, A Bankovacki, ... Blood, The Journal of the American Society of Hematology 123 (16), 2562-2572, 2014 | 178 | 2014 |
| HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death AV Jacobsen, KN Lowes, MC Tanzer, IS Lucet, JM Hildebrand, EJ Petrie, ... Cell death & disease 7 (1), e2051-e2051, 2016 | 170 | 2016 |
John SilkeProfessor, The Walter and Eliza Hall Institutelatrobe.edu.au의 이메일 확인됨
