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Frederick S Varn
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Longitudinal molecular trajectories of diffuse glioma in adults
FP Barthel, KC Johnson, FS Varn, AD Moskalik, G Tanner, E Kocakavuk, ...
Nature 576 (7785), 112-120, 2019
4812019
Glioma progression is shaped by genetic evolution and microenvironment interactions
FS Varn, KC Johnson, J Martinek, JT Huse, MLP Nasrallah, P Wesseling, ...
Cell 185 (12), 2184-2199. e16, 2022
2882022
Immunoregulatory functions of VISTA
EC Nowak, JL Lines, FS Varn, J Deng, A Sarde, R Mabaera, A Kuta, ...
Immunological reviews 276 (1), 66-79, 2017
2212017
Hypoxia-induced VISTA promotes the suppressive function of myeloid-derived suppressor cells in the tumor microenvironment
J Deng, J Li, A Sarde, JL Lines, YC Lee, DC Qian, DA Pechenick, ...
Cancer immunology research 7 (7), 1079-1090, 2019
1902019
Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response
KC Johnson, KJ Anderson, ET Courtois, AD Gujar, FP Barthel, FS Varn, ...
Nature genetics 53 (10), 1456-1468, 2021
1722021
Systematic Pan-Cancer Analysis Reveals Immune Cell Interactions in the Tumor Microenvironment
FS Varn, Y Wang, DW Mullins, S Fiering, C Cheng
Cancer research 77 (6), 1271-1282, 2017
1682017
Very low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy
M Gromeier, MC Brown, G Zhang, X Lin, Y Chen, Z Wei, N Beaubier, ...
Nature communications 12 (1), 352, 2021
1162021
Radiotherapy is associated with a deletion signature that contributes to poor outcomes in patients with cancer
E Kocakavuk, KJ Anderson, FS Varn, KC Johnson, SB Amin, EP Sulman, ...
Nature genetics 53 (7), 1088-1096, 2021
1152021
Perspective of mesenchymal transformation in glioblastoma
Y Kim, FS Varn, SH Park, BW Yoon, HR Park, C Lee, RGW Verhaak, ...
Acta neuropathologica communications 9, 1-20, 2021
1052021
Comparative molecular life history of spontaneous canine and human gliomas
SB Amin, KJ Anderson, CE Boudreau, E Martinez-Ledesma, E Kocakavuk, ...
Cancer cell 37 (2), 243-257. e7, 2020
862020
Therapeutically targeting tumor microenvironment–mediated drug resistance in estrogen receptor–positive breast cancer
K Shee, W Yang, JW Hinds, RA Hampsch, FS Varn, NA Traphagen, ...
Journal of Experimental Medicine 215 (3), 895-910, 2018
742018
Adaptive immunity programmes in breast cancer
FS Varn, DW Mullins, H Arias‐Pulido, S Fiering, C Cheng
Immunology 150 (1), 25-34, 2017
692017
Identification, validation and biological characterisation of novel glioblastoma tumour microenvironment subtypes: implications for precision immunotherapy
K White, K Connor, M Meylan, A Bougoüin, M Salvucci, F Bielle, ...
Annals of Oncology 34 (3), 300-314, 2023
552023
A P53-deficiency gene signature predicts recurrence risk of patients with early-stage lung adenocarcinoma
Y Zhao, FS Varn, G Cai, F Xiao, CI Amos, C Cheng
Cancer Epidemiology, Biomarkers & Prevention 27 (1), 86-95, 2018
532018
Integrative analysis of breast cancer reveals prognostic haematopoietic activity and patient-specific immune response profiles
FS Varn, EH Andrews, DW Mullins, C Cheng
Nature communications 7 (1), 10248, 2016
532016
Computational immune profiling in lung adenocarcinoma reveals reproducible prognostic associations with implications for immunotherapy
FS Varn, LJ Tafe, CI Amos, C Cheng
Oncoimmunology 7 (6), e1431084, 2018
522018
Single-cell RNA sequencing reveals the impact of chromosomal instability on glioblastoma cancer stem cells
Y Zhao, R Carter, S Natarajan, FS Varn, DA Compton, C Gawad, C Cheng, ...
BMC medical genomics 12, 1-16, 2019
502019
Multifactorial deep learning reveals pan-cancer genomic tumor clusters with distinct immunogenomic landscape and response to immunotherapy
F Xie, J Zhang, J Wang, A Reuben, W Xu, X Yi, FS Varn, Y Ye, J Cheng, ...
Clinical Cancer Research 26 (12), 2908-2920, 2020
452020
Genomic characterization of six virus-associated cancers identifies changes in the tumor immune microenvironment and altered genetic programs
FS Varn, E Schaafsma, Y Wang, C Cheng
Cancer research 78 (22), 6413-6423, 2018
402018
A B cell-derived gene expression signature associates with an immunologically active tumor microenvironment and response to immune checkpoint blockade therapy
FS Varn, Y Wang, C Cheng
OncoImmunology 8 (1), e1513440, 2019
272019
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