| Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents C Lugnier Pharmacology & therapeutics 109 (3), 366-398, 2006 | 1138 | 2006 |
| Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for … T Keravis, C Lugnier British journal of pharmacology 165 (5), 1288-1305, 2012 | 440 | 2012 |
| Selective inhibition of cyclic nucleotide phosphodiesterases of human, bovine and rat aorta C Lugnier, P Schoeffter, A Le Bec, E Strouthou, JC Stoclet Biochemical pharmacology 35 (10), 1743-1751, 1986 | 403 | 1986 |
| Synthesis and anti-inflammatory activity of phthalimide derivatives, designed as new thalidomide analogues LM Lima, P Castro, AL Machado, CAM Fraga, C Lugnier, VLG De Moraes, ... Bioorganic & medicinal chemistry 10 (9), 3067-3073, 2002 | 274 | 2002 |
| Endothelium‐dependent and independent relaxation of the rat aorta by cyclic nucleotide phosphodiesterase inhibitors N Komas, C Lugnier, JC Stoclet British journal of pharmacology 104 (2), 495-503, 1991 | 174 | 1991 |
| Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1 M Alhosin, A Abusnina, M Achour, T Sharif, C Muller, J Peluso, ... Biochemical pharmacology 79 (9), 1251-1260, 2010 | 167 | 2010 |
| Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on β-adrenergic cAMP signals A Abi-Gerges, W Richter, F Lefebvre, P Mateo, A Varin, C Heymes, ... Circulation research 105 (8), 784-792, 2009 | 154 | 2009 |
| Characterization of cyclic nucleotide phosphodiesterases from cultured bovine aortic endothelial cells C Lugnier, VB Schini Biochemical pharmacology 39 (1), 75-84, 1990 | 147 | 1990 |
| VEGF-induced HUVEC migration and proliferation are decreased by PDE2 and PDE4 inhibitors L Favot, T Keravis, V Holl, A Le Bec, C Lugnier Thrombosis and haemostasis 90 (08), 334-343, 2003 | 137 | 2003 |
| Negative feedback exerted by cAMP-dependent protein kinase and cAMP phosphodiesterase on subsarcolemmal cAMP signals in intact cardiac myocytes: an in vivo study using … F Rochais, G Vandecasteele, F Lefebvre, C Lugnier, H Lum, JL Mazet, ... Journal of Biological Chemistry 279 (50), 52095-52105, 2004 | 136 | 2004 |
| Modulation of vascular cyclic nucleotide phosphodiesterases by cyclic GMP: role in vasodilatation. C Lugnier, N Komas European heart journal 14, 141-148, 1993 | 134 | 1993 |
| Design, Synthesis, and Pharmacological Evaluation of N-Acylhydrazones and Novel Conformationally Constrained Compounds as Selective and Potent Orally … AE Kümmerle, M Schmitt, SVS Cardozo, C Lugnier, P Villa, AB Lopes, ... Journal of medicinal chemistry 55 (17), 7525-7545, 2012 | 124 | 2012 |
| Anti‐proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1 A Abusnina, T Keravis, I Yougbaré, C Bronner, C Lugnier Molecular nutrition & food research 55 (11), 1677-1689, 2011 | 122 | 2011 |
| Delphinidin inhibits endothelial cell proliferation and cell cycle progression through a transient activation of ERK-1/-2 S Martin, L Favot, R Matz, C Lugnier, R Andriantsitohaina Biochemical pharmacology 65 (4), 669-675, 2003 | 120 | 2003 |
| Thymoquinone reduces migration and invasion of human glioblastoma cells associated with FAK, MMP-2 and MMP-9 down-regulation K Kolli-Bouhafs, A Boukhari, A Abusnina, E Velot, JP Gies, C Lugnier, ... Investigational new drugs 30, 2121-2131, 2012 | 119 | 2012 |
| Involvement of cyclin-dependent pathway in the inhibitory effect of delphinidin on angiogenesis L Favot, S Martin, T Keravis, R Andriantsitohaina, C Lugnier Cardiovascular research 59 (2), 479-487, 2003 | 119 | 2003 |
| Molecular organization of bovine rod cGMP-phosphodiesterase 6 JFK Tcheudji, L Lebeau, N Virmaux, CG Maftei, RH Cote, C Lugnier, ... Journal of molecular biology 310 (4), 781-791, 2001 | 112 | 2001 |
| Calmodulin and its role in intracellular calcium regulation JC Stoclet, D Gérard, MC Kilhoffer, C Lugnier, R Miller, P Schaeffer Progress in neurobiology 29 (4), 321-364, 1987 | 111 | 1987 |
| Bepridil and flunarizine as calmodulin inhibitors C Lugnier, A Follenius, D Gerard, JC Stoclet European journal of pharmacology 98 (1), 157-158, 1984 | 107 | 1984 |
| Implication of cyclic nucleotide phosphodiesterase inhibition in the vasorelaxant activity of the citrus-fruits flavonoid (±)-naringenin F Orallo, M Camiña, E Alvarez, H Basaran, C Lugnier Planta medica 71 (02), 99-107, 2005 | 106 | 2005 |
