X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease S Günther, PYA Reinke, Y Fernández-García, J Lieske, TJ Lane, HM Ginn, ... Science 372 (6542), 642-646, 2021 | 336 | 2021 |
Crystal structures of nucleotide-free and glutathione-bound mitochondrial ABC transporter Atm1 V Srinivasan, AJ Pierik, R Lill Science 343 (6175), 1137-1140, 2014 | 250 | 2014 |
The role of mitochondria and the CIA machinery in the maturation of cytosolic and nuclear iron–sulfur proteins R Lill, R Dutkiewicz, SA Freibert, T Heidenreich, J Mascarenhas, DJ Netz, ... European journal of cell biology 94 (7-9), 280-291, 2015 | 211 | 2015 |
Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic β2-microglobulin variant K Domanska, S Vanderhaegen, V Srinivasan, E Pardon, F Dupeux, ... Proceedings of the National Academy of Sciences 108 (4), 1314-1319, 2011 | 153 | 2011 |
The role of mitochondria in cytosolic-nuclear iron–sulfur protein biogenesis and in cellular iron regulation R Lill, V Srinivasan, U Mühlenhoff Current opinion in microbiology 22, 111-119, 2014 | 139 | 2014 |
Catalytic mechanism and allosteric regulation of an oligomeric (p) ppGpp synthetase by an alarmone W Steinchen, JS Schuhmacher, F Altegoer, CD Fage, V Srinivasan, ... Proceedings of the National Academy of Sciences 112 (43), 13348-13353, 2015 | 128 | 2015 |
Insights into the mode of action of a putative zinc transporter CzrB in Thermus thermophilus V Cherezov, N Höfer, DME Szebenyi, O Kolaj, JG Wall, R Gillilan, ... Structure 16 (9), 1378-1388, 2008 | 110 | 2008 |
Structure of the yeast WD40 domain protein Cia1, a component acting late in iron-sulfur protein biogenesis V Srinivasan, DJA Netz, H Webert, J Mascarenhas, AJ Pierik, H Michel, ... Structure 15 (10), 1246-1257, 2007 | 100 | 2007 |
Metal-induced conformational changes in ZneB suggest an active role of membrane fusion proteins in efflux resistance systems F De Angelis, JK Lee, JD O'Connell III, LJW Miercke, KH Verschueren, ... Proceedings of the National Academy of Sciences 107 (24), 11038-11043, 2010 | 88 | 2010 |
A llama-derived gelsolin single-domain antibody blocks gelsolin–G-actin interaction A Van den Abbeele, S De Clercq, A De Ganck, V De Corte, B Van Loo, ... Cellular and molecular life sciences 67, 1519-1535, 2010 | 81 | 2010 |
Structures and functions of mitochondrial ABC transporters TA Schaedler, B Faust, CA Shintre, EP Carpenter, V Srinivasan, ... Biochemical Society Transactions 43 (5), 943-951, 2015 | 79 | 2015 |
Controlled inhibition of methyltransferases using photoswitchable peptidomimetics: towards an epigenetic regulation of leukemia L Albert, J Xu, R Wan, V Srinivasan, Y Dou, O Vázquez Chemical Science 8 (6), 4612-4618, 2017 | 58 | 2017 |
Directed Evolution of an FeII-Dependent Halogenase for Asymmetric C(sp3)–H Chlorination S Duewel, L Schmermund, T Faber, K Harms, V Srinivasan, E Meggers, ... ACS Catalysis 10 (2), 1272-1277, 2019 | 48 | 2019 |
Constraining enzyme conformational change by an antibody leads to hyperbolic inhibition D Oyen, V Srinivasan, J Steyaert, JN Barlow Journal of molecular biology 407 (1), 138-148, 2011 | 45 | 2011 |
Allosteric inhibition of VIM metallo-β-lactamases by a camelid nanobody JS Sohier, C Laurent, A Chevigné, E Pardon, V Srinivasan, U Wernery, ... Biochemical Journal 450 (3), 477-486, 2013 | 43 | 2013 |
Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease V Srinivasan, H Brognaro, PR Prabhu, EE de Souza, S Günther, ... Communications biology 5 (1), 805, 2022 | 38 | 2022 |
Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihydrofolate reductase of Escherichia coli D Oyen, R Wechselberger, V Srinivasan, J Steyaert, JN Barlow Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1834 (10), 2147-2157, 2013 | 35 | 2013 |
IscR of Rhodobacter sphaeroides functions as repressor of genes for iron‐sulfur metabolism and represents a new type of iron‐sulfur‐binding protein B Remes, BD Eisenhardt, V Srinivasan, G Klug Microbiologyopen 4 (5), 790-802, 2015 | 22 | 2015 |
Structure at 1.3 Å resolution of Rhodothermus marinus caa3 cytochrome c domain V Srinivasan, C Rajendran, FL Sousa, AMP Melo, LM Saraiva, ... Journal of molecular biology 345 (5), 1047-1057, 2005 | 18 | 2005 |
Hydrazones and thiosemicarbazones targeting protein-protein-interactions of SARS-CoV-2 papain-like protease W Ewert, S Günther, F Miglioli, S Falke, PYA Reinke, S Niebling, ... Frontiers in Chemistry 10, 832431, 2022 | 14 | 2022 |